Objective To explore the design and clinical application of the bedsheet with postural markers during gastroscopy.Methods A total of 100 outpatients who underwent gastroscopy for the first time in Digestive Endoscopy Center of The First Affiliated Hospital of Naval Medical University from November to December 2021 were selected as research objects by convenience sampling coin method.They were randomly divided into experimental group(n=54)and control group(n=46).The bedsheets with postural markers were used in the experimental group,and ordinary disposable sheets were used in the control group during gastroscopy.One-time success rate of postural placement,time from guidance to completion of postural placement,and patient satisfaction were compared between the 2 groups.Results The time from guidance to completion of postural placement in the experimental group was shorter than that in the control group([7.07±2.44]vs[18.36±5.12]),and the one-time success rate of postural placement(96.30% vs 13.04% )and patient satisfaction([95.76±4.32]vs[68.46±7.59])in the experimental group were significantly higher than those in the control group(P<0.01).Conclusion The clinical application of bedsheets with postural markers during gastroscopy can significantly increase the efficiency of postural placement,shorten the guidance time before operation,maximize the utilization rate of examination beds,and improve patient satisfaction.

Objective:To explore the effects of maternal exposure to Morinda officinalis oligosaccharides (MOO) during lactation on the Sprague-Dawley (SD) maternal rats and their offspring's growth and development. Methods:Seventy-two female rats with a surviving litter size of ≥ 6 were divided into the excipients control group, MOO low-dose group (50 mg/kg), MOO medium-dose group (160 mg/kg), and MOO high-dose group (500 mg/kg) using a snake-shaped grouping based on body weight, with 18 rats per group. The rats were gavage fed once daily until 20 days of delivery. The response of maternal rats after MOO exposure during lactation, as well as the appearance, response, gross anatomical abnormalities of their F1 and F2 offspring were observed. The body weight and food intake of maternal rats during lactation and those of their offspring before and after weaning were measured. The behavior (central nervous system function) of the F1 and F2 offspring was evaluated using functional observation battery (FOB). The learning and memory function of the F1 offspring was evaluated using Y-maze test. The male and female F1 offspring in the same dose group were mated when they were raised to 10-12 weeks in order to observe the reproductive function of F1 female rats.Results:Compared with the excipients control group, no abnormality was found in the clinical observation of maternal rats in the 3 MOO exposure groups during lactation, and there was no significant differences in their body weight and daily food intake during lactation (all P>0.05). No significant effects were found on the appearance, clinical symptoms, gross anatomy, body weight, and food intake of the F1 and F2 offspring after maternal rats receiving MOO exposure during lactation. In the FOB of the F1 and F2 offspring and the Y-maze test of F1 offspring, few differences in MOO exposure groups were observed and lack of significant dose-response relationship. After pregnancy, there were no statistically significant differences in the number of corpus luteum, implantation number, birth index, delivery index, survival index, and weaning index in F1 female offspring of maternal rats exposed to MOO at different doses during lactation compared with those of the excipients control group (all P>0.05). Conclusions:There were no obvious toxic reactions in maternal rats after exposure to different doses of MOO during lactation, nor in the growth and development, nervous system, learning and memory, and reproductive function of their offspring.

Objective:To explore the effects of maternal exposure to Morinda officinalis oligosaccharides (MOO) during lactation on the Sprague-Dawley (SD) maternal rats and their offspring's growth and development. Methods:Seventy-two female rats with a surviving litter size of ≥ 6 were divided into the excipients control group, MOO low-dose group (50 mg/kg), MOO medium-dose group (160 mg/kg), and MOO high-dose group (500 mg/kg) using a snake-shaped grouping based on body weight, with 18 rats per group. The rats were gavage fed once daily until 20 days of delivery. The response of maternal rats after MOO exposure during lactation, as well as the appearance, response, gross anatomical abnormalities of their F1 and F2 offspring were observed. The body weight and food intake of maternal rats during lactation and those of their offspring before and after weaning were measured. The behavior (central nervous system function) of the F1 and F2 offspring was evaluated using functional observation battery (FOB). The learning and memory function of the F1 offspring was evaluated using Y-maze test. The male and female F1 offspring in the same dose group were mated when they were raised to 10-12 weeks in order to observe the reproductive function of F1 female rats.Results:Compared with the excipients control group, no abnormality was found in the clinical observation of maternal rats in the 3 MOO exposure groups during lactation, and there was no significant differences in their body weight and daily food intake during lactation (all P>0.05). No significant effects were found on the appearance, clinical symptoms, gross anatomy, body weight, and food intake of the F1 and F2 offspring after maternal rats receiving MOO exposure during lactation. In the FOB of the F1 and F2 offspring and the Y-maze test of F1 offspring, few differences in MOO exposure groups were observed and lack of significant dose-response relationship. After pregnancy, there were no statistically significant differences in the number of corpus luteum, implantation number, birth index, delivery index, survival index, and weaning index in F1 female offspring of maternal rats exposed to MOO at different doses during lactation compared with those of the excipients control group (all P>0.05). Conclusions:There were no obvious toxic reactions in maternal rats after exposure to different doses of MOO during lactation, nor in the growth and development, nervous system, learning and memory, and reproductive function of their offspring.

Objective:To analyze risk factors of dry eye in patients with type 2 diabetic retinopathy, construct a dry eye risk nomogram model and conduct external verification.Methods:The study was a cross-sectional study. A total of 366 patients with type 2 diabetic retinopathy treated in the Ophthalmology Clinic of the First Affiliated Hospital of Naval Medical University from March 2020 to November 2021 were conveniently selected as the research objects. They were divided into the modeling group and the validation group by random number table method, with 183 cases in each group. The prevalence of dry eye in patients with type 2 diabetic retinopathy was counted. The risk factors of dry eye were screened by univariate analysis and binomial Logistic regression analysis, and the nomogram model of dry eye risk was constructed based on the data of the patients in the modeling group. Calibration curve and receiver operating characteristic (ROC) curve analysis were performed on the data of patients in the validation group to evaluate the calibration and discrimination of the nomogram model.Results:The prevalence of dry eye in patients with type 2 diabetic retinopathy was 57.38% (210/366) . More than 60 years old, more than 4 hours of daily screen viewing time, duration of diabetes longer than or equal to 5 years, glycated hemoglobin greater than equal to 7.0% and diabetic retinopathy grade of severe non-proliferative type and proliferative type were risk factors for dry eye in patients with type 2 diabetic retinopathy ( P<0.05) , and sleep time greater than or equal to 7 hours per night was a protective factor ( P<0.01) . The χ 2 value of Hosmer-Lemeshow test of the nomogram model of dry eye risk constructed by six factors was 14.280 ( P=0.075) , showing that the actual observation curve was consistent with the predicted curve. The area under the ROC curve was 0.815 (95% CI: 0.750-0.880) . Conclusions:Patients with type 2 diabetic retinopathy have a high prevalence of dry eye. More than 60 years old, more than 4 hours of daily screen viewing time, duration of diabetes longer than or equal to 5 years, glycated hemoglobin greater than equal to 7.0% and diabetic retinopathy grade of severe non-proliferative type and proliferative type are risk factors for dry eye in patients with type 2 diabetic retinopathy, and sleep time greater than or equal to 7 hours per night is a protective factor. The nomogram model constructed in this study has good calibration and discrimination, which can help medical staff identify the risk of dry eye as early as possible.