Objective To compare the therapeutic efficacies and toxicities either of pemetrexed or paclitaxel combined with oxaliplatin as a chemotherapy in postoperative with non‐small‐cell lung cancer(NSCLC) .Methods The clinical data collected from 86 patients who admitted into the first affiliated hospital of Kunming medical university from January 2010 to December 2011 who had been diagnosed with non‐small‐cell lung cancer(NSCLC) were retrospectively analyzed .All of these patients received the radical resection of pulmonary carcinoma ,in which 65 patients received pemetrexed combined with oxaliplatin treatment(named as peme‐trexed combination group) .Another 40 patients were treated with paclitaxel combined with oxaliplatin (named as paclitaxel combi‐nation group) .Survival analysis was evaluated by Kaplan‐Merie .Single factor analysis and COX regression model were employed to analyze the relationship between the influencing factors and the prognosis of disease .Results We found that neither OS (χ2 =0 .648 ,P=0 .421) nor PFS(χ2 =0 .758 ,P=0 .384)was statistical different between two groups .However ,the incidence of leucope‐nia above Ⅲ degrees was 34 .8% in pemetrexed combination group ,and 60 .0% in paclitaxel combination group(χ2 = 5 .469 ,P=0 .019) .The incidence of of ALT increase above Ⅲ degrees was 12 .2% in pemetrexed combination group ,and 35 .0% in paclitaxel combination group(χ2 =7 .238 ,P=0 .007) .The incidence of AST increase rate above Ⅲ degrees was 13 .0% in pemetrexed combi‐nation group and 32 .5% in paclitaxel combination group(χ2 = 4 .706 ,P= 0 .030) .The incidence of neurotoxicity was 28 .2% in pemetrexed combined group ,65 .0% in paclitaxel combined group (χ2 = 11 .652 ,P= 11 .652) .The incidence of gastrointestinal tract reaction above Ⅲ degrees was 47 .8% in pemetrexed combined group ,57 .5% in paclitaxel combined group was ,(χ2 = 0 .803 , P=0 .370) .Cox regression analysis revealed that PS score(HR=0 .207 ,95% CI:0 .090-0 .479) and clinical stages(HR=0 .089 , 95% CI:0 .041-0 .191) had significant effects on survival of patients .Conclusion Two kinds of treatment in two groups showed the similar curative effects and promised to be first‐line chemotherapy strategy for postoperative patients with NSCLC .However , the pemetrexed combined group showed less drug toxicity compared with that of the paclitaxel combined group .

OBJECTIVETo study the relationship between body mass index (BMI), hypertension and all-cause mortality in the elderly population in Beijing.

METHODSIn 1992, a cohort of 3 257 people above 55 years old was selected from 3 different areas of Beijing, i.e. urban and suburbs (both plain and mountain areas). Information on physical condition, history of chronic diseases, self-perceived health, as well as smoking and drinking status was collected. Blood pressure, body height and weight were measured among 2 086 of 3 257 subjects.

RESULTSBMI was decreasing with age, while the prevalence of hypertension increased with age. Meanwhile the prevalence of hypertension increased with age as well as with BMI. There was a reverse relationship between BMI and all-cause mortality, i.e. the risk of death was 39.0% lower for those with BMI = 20.0 - 24.9 kg/m(2) (Hazard ratio: 0.61, 95% Confidence interval: 0.49 - 0.75) and 62% lower for those with BMI >/= 25.0 kg/m(2) (Hazard ratio: 0.38%, 95% Confidence interval: 0.29 - 0.49) than those with BMI < 20.0 kg/m(2). After controlling for age, gender, residential place, hypertension as well as self-perceive health status and cognition function, low BMI remained a significant and independent predictor to death.

CONCLUSIONThe distribution of BMI was different in elderly from the youth. The findings suggested that it was important to control the body weight among the elderly hypertensives.

Age Factors ; Aged ; Aged, 80 and over ; Body Height ; Body Mass Index ; Body Weight ; Cause of Death ; China ; epidemiology ; Female ; Humans ; Hypertension ; epidemiology ; physiopathology ; Male ; Middle Aged ; Risk Factors ; Rural Health ; statistics & numerical data ; Sex Factors ; Urban Health ; statistics & numerical data

Objective To find out about the current health situation of the elderly in the Beijing area and their health care needs so as to provide basis for the formulation of health care policies for the elderly by the government and relevant departments and for the development of health care programs for the elderly in accordance with their needs. Methods A sample survey, covering such topics as the health situation, medical treatment, nursing, rehabilitation and health care needs of the elderly and community health service, was made of 2 487 elderly people aged 60 and above in different parts of Beijing, including the city proper, the part linking city and country, and the suburbs. An analysis was then made of the difference in the health situation and health care needs of the elderly between various parts and populations. Results Chronic diseases constituted the major health problem for the elderly, with hypertension, coronary heart disease, osteoarthrosis, and cerebrovascular disease ranking in the first four places and the incidence of diabetes increasing rapidly. About 10 percent of the elderly, who suffered from somatic dysfunction, had reduced daily life skills and needed assistance from others. An increased number of elderly people also meant a greater demand for medical and nursing services. Community health service, the advantages of which bacame increasingly manifest, was thus popular with the elderly. Financial difficulty was the chief factor affecting the elderly in their seeking medical service. Conclusion The elderly is a weak population in health. With the aging of the general population, the health care needs of the elderly are on the rise. As health is the major factor affecting the life quality of the elderly, enhanced efforts in the prevention and treatment of chronic diseases ought to be taken as the central task in the health care of the elderly. They are also the key to improving the life quality of the elderly.

Objective To analyze the influence of elderly dementia living in urban and rural areas of Beijing on their survival rate. Methods The elderly people with dementia aged 60 years and over lived in Beijing was investigated since 1997 by two step method and the mortality of the same population was followed up in 2000. Results A total of 2 788 patients were collected in 1997, and 2 721 of them were visited in 2000. Sixty seven(2 4%) of them were lost for follow up due to making a move and other reasons. Among the followed 2 721 cases , 2 307 were still alive (82 7%) and 414 died (14 9%), with the annual fatality rate being 3 79%(standardized). For all 205 cases diagnosed as dementia in 1997, the accumulated fatality rate was 42 46%(standardized), being 5 folds of the fatality for the non dementia. No significant difference was found in the fatality rate between male and female dementia. The fatality of dementia in rural area and over 75 years of age increased. Age and living conditions influenced significantly the fatality, and the fatality rate increased in patients with dementia and dysfunction of body moving. Conclusions Dementia is a disease impacting seriously the survival of elderly people.