Premature ovarian insufficiency (POI) leads to reproductive aging in young women, such as reduced fertility and reduced hormone levels, which seriously affects women's physical and mental health and quality of life. The pathogenesis of POI is still unclear, and there is a large unknown space. In-depth exploration of its etiology and mechanism using animal models has important clinical significance, which can help identify and avoid risk factors in advance, and formulate targeted prevention and treatment strategies. Through the analysis and study of different POI mouse models, this paper can provide a reference for the basic research of POI and a new idea for improving the fertility of women of childbearing age.

Premature ovarian insufficiency (POI) leads to reproductive aging in young women, such as reduced fertility and reduced hormone levels, which seriously affects women's physical and mental health and quality of life. The pathogenesis of POI is still unclear, and there is a large unknown space. In-depth exploration of its etiology and mechanism using animal models has important clinical significance, which can help identify and avoid risk factors in advance, and formulate targeted prevention and treatment strategies. Through the analysis and study of different POI mouse models, this paper can provide a reference for the basic research of POI and a new idea for improving the fertility of women of childbearing age.