Objective To investigate the expression of indoleamine 2,3-dioxygenase 1(IDO1)and kynure-ninase(KYNU)in oral squamous cell carcinoma(OSCC)and their relationship with pathological features and prognosis.Methods A total of 98 OSCC patients admitted to the hospital from January 2018 to June 2020 were enrolled in the study.OSCC tissue samples and corresponding adjacent tissue samples were collected.Im-munohistochemical method was used to detect the expression of IDO1 and KYNU in tissues.The relationship between IDO1 and KYNU expression and the clinicopathological characteristics of OSCC patients was ana-lyzed.Multivariate Cox regression analysis was used to analyze the factors affecting the prognosis of OSCC pa-tients.Results The positive expression rates of IDO1 and KYNU in OSCC tissues were higher than those in adjacent tissues(P＜0.05).The positive expression rates of IDO1 and KYNU in patients with poor differenti-ation,depth of invasion(DOI)＞5 mm,lymph node metastasis,and clinical stage Ⅲ-Ⅳ were higher than those in patients with medium or high differentiation,DOI＜5 mm,no lymph node metastasis,and clinical stage Ⅰ-Ⅱ,respectively(P＜0.05).The 3-year overall survival rates of OSCC patients with medium or high differentiation,DOI＜5 mm,no lymph node metastasis,clinical stage Ⅰ-Ⅱ,negative expression of IDO1,and negative expression of KYNU were higher than those of OSCC patients with low differentiation,DOI＞5 mm,lymph node metastasis,clinical stage Ⅲ-Ⅳ,positive expression of IDO1,and positive expression of KYNU,respectively(P＜0.05).Multivariate Cox regression analysis showed that DOI＞5 mm(HR=3.225,95％CI:1.496-6.954),positive expression of IDO1(HR=3.714,95％CI:1.941-7.105),positive expression of KYNU(HR=4.150,95％CI:1.887-9.124)were the influencing factors of the prognosis of OSCC patients(P＜0.05).Conclusion IDO1 and KYNU are highly expressed in cancer tissues of OSCC patients,which are closely related to the DOI,clinical stage,and differentiation degree of OSCC.IDO1 and KYNU are hopeful to be used as markers to assist in evaluating the prognosis of patients.

Objective To explore the predictive value of serum soluble myeloid cell trigger receptor-1(sTREM-1)and heparin-binding protein(HBP)on postoperative infection in cases with oral and maxillofacial tumors complicated with diabetes mellitus.Methods A total of 110 patients with oral and maxillofacial tumors complicated with diabetes mellitus treated in the hospital from January 2020 to December 2022 were selected as the study objects,and the patients were divided into uninfected group(n=83)and infected group(n=27)according to the occurrence of postoperative infection.Serum sTREM-1 and HBP levels in patients with oral and maxillofacial tumors diabetes mellitus before surgery were detected by enzyme-linked immu-nosorbent assay.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum sTREM-1 and HBP on postoperative infection in patients.The related factors of postoperative infection were investigated by multivariate Logistic regression.Results The levels of sTREM-1 and HBP in the infec-ted group were higher compared with the uninfected group,and the differences were statistically significant(P＜0.05).The area under the curve(AUC)of serum sTREM-1 and HBP levels in predicting postoperative infection was 0.707(95％CI:0.661-0.756)and 0.885(95％CI:0.838-0.931),respectively,and the AUC of the combined prediction was 0.931(95％CI:0.889-0.975).The number of patients with hypertension,in-traoperative blood loss,operation time and hospital stay in infected group was higher compared with in non-in-fected group,and the number of advanced nursing was lower compared with the uninfected group,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression results showed that the length of hospitalization≥14 d(OR=2.401,95％CI:1.331-4.332),sTREM-1＞50.49 pg/mL(OR=3.494,95％CI:1.601-7.662),HBP＞159.84 ng/L(OR=4.473,95％CI:1.819-10.997)were the influential fac-tors for postoperative infection(P＜0.05).Conclusion Preoperative serum sTREM-1 and HBP levels are sig-nificantly increased in patients with oral and maxillofacial tumor complicated with diabetes mellitus who also have postoperative infection,and the increase of serum sTREM-1 and HBP levels are influential factor for postoperative infection,and the two levels have certain clinical value in assisting the evaluation of postopera-tive infection.