Diabetic chronic wounds are one of the significant complications among diabetic patients,with an incidence that is rising annually.Given the substantial societal burden and complex pathophysiology of diabetic chronic wounds.There is an urgent need to develop new and more effective treatment modalities.Recently,cell-free therapies,particularly those involving extracellular vesicles such as exosomes,have gained prominence.This paper summarizes the therapeutic application of extracellular vesicles in the treatment of delayed wound healing in diabetes,explores the potential molecular mechanisms involved,and discusses the clinical value of extracellular vesicles in preventing and treating delayed wound healing in diabetes.

Diabetic chronic wounds are one of the significant complications among diabetic patients,with an incidence that is rising annually.Given the substantial societal burden and complex pathophysiology of diabetic chronic wounds.There is an urgent need to develop new and more effective treatment modalities.Recently,cell-free therapies,particularly those involving extracellular vesicles such as exosomes,have gained prominence.This paper summarizes the therapeutic application of extracellular vesicles in the treatment of delayed wound healing in diabetes,explores the potential molecular mechanisms involved,and discusses the clinical value of extracellular vesicles in preventing and treating delayed wound healing in diabetes.