Objective:To design a vest-type breast dressing bra and explore its application effect in the external application of traditional Chinese medicine therapy for patients with granulomatous lobular mastitis(GLM).Methods:A randomized controlled study was conducted, utilizing convenience sampling to select female patients with 122 GLM who underwent their first topical medication treatment in the Breast Department of Guangdong Provincial Hospital of Traditional Chinese Medicine between January and May 2023. The patients were divided into a control group and an observation group, with 61 patients in each, using a random number table. Following medication application, patients in the control group used a regular sports bra to secure the medication, while patients in the observation group used a custom-designed vest-style breast medication bra for the same purpose. Three hours after the intervention, comparisons were made between the two groups in terms of the incidence of medication detachment, medication displacement, clothing contamination, patient satisfaction, and safety.Results:Both groups of patients completed the study. The age of the observation group was (32.18 ± 5.50) years old, while the age of the control group was (33.66 ± 5.20) years old. Three hours after the intervention, the incidence of medication detachment, medication displacement, clothing contamination in the observation group were 3.28% (2/61), 6.56% (4/61), and 8.20% (5/61), which were lower than those in the control group with 18.03% (11/61), 26.23% (16/61), and 67.21% (41/61), respectively. The differences were statistically significant ( χ2=6.97, 8.61, 45.23; all P<0.05). The satisfaction level of patients towards the bra in the observation group was (4.43 ± 0.85) points, higher than that of the control group (3.85 ± 1.08) points, with a statistically significant difference ( t=3.30, P<0.05). The incidence rates of skin allergic reactions were 3.28%(2/61) and 4.92%(3/61) in the observation group and the control group, respectively, with no statistically significant difference ( P>0.05). Conclusions:The vest-type breast dressing bra designed in this study can properly secure the medicinal paste, reduce the rate of medication detachment, medication displacement, clothing contamination, and enhance patient satisfaction. It facilitates the external application of traditional Chinese medicine for patients with GLM and is worthy of clinical promotion.

Xiaoaiping (XAP) Injection demonstrates the anti-prostate cancer (PCa) effects, yet the underlying mechanism remains unclear. This study aims to investigate the impact of XAP on PCa and elucidate its mechanism of action. PCa cell proliferation was evaluated using a cell counting kit-8 (CCK-8) assay. Cell apoptosis was assessed through Hoechst staining and Western blotting assays. Proteomics technology was employed to identify key molecules and significant signaling pathways modulated by XAP in PCa cells. To further validate potential key genes and important pathways, a series of assays were conducted, including acridine orange (AO) staining, transmission electron microscopy, and immunofluorescence assays. The molecular mechanism of XAP against PCa in vivo was examined using a PC3 xenograft mouse model. Results demonstrated that XAP significantly inhibited cell proliferation in multiple PCa cell lines. In C4-2 and prostate cancer cell line-3 (PC3) cells, XAP induced cellular apoptosis, evidenced by reduced B-cell lymphoma 2 (Bcl-2) levels and elevated Bcl-2-associated X (Bax) levels. Proteomic, immunofluorescence, and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) investigations revealed a strong correlation between forkhead box O3a (FoxO3a) autophagic degradation and the anti-PCa action of XAP. XAP hindered autophagy by reducing the expression levels of autophagy-related protein 5 (Atg5)/autophagy-related protein 12 (Atg12) and enhancing FoxO3a expression and nuclear translocation. Furthermore, XAP exhibited potent anti-PCa action in PC3 xenograft mice and triggered FoxO3a nuclear translocation in tumor tissue. These findings suggest that XAP induces PCa apoptosis via inhibition of FoxO3a autophagic degradation, potentially offering a novel perspective on XAP injection as an effective anticancer therapy for PCa.
Male ; Humans ; Prostatic Neoplasms/physiopathology* ; Autophagy/drug effects* ; Animals ; Drugs, Chinese Herbal/pharmacology* ; Proteomics ; Mice ; Apoptosis/drug effects* ; Cell Line, Tumor ; Cell Proliferation/drug effects* ; Forkhead Box Protein O3/genetics* ; Xenograft Model Antitumor Assays ; Mice, Nude ; Mice, Inbred BALB C

Objective To observe the value of contrast-enhanced ultrasound(CEUS)for diagnosing splenic lymphoma.Methods Eighteen patients with pathologically confirmed splenic lymphoma were retrospectively collected.The routine ultrasound and CEUS manifestations of lesions were observed,and the diagnostic accuracy of these two methods for diagnosing splenic lymphoma were compared.Results Among 18 cases,conventional ultrasound showed single lesion in 8(8/18,44.44％)and multiple lesions in 10 cases(10/18,55.56％).The maximum diameter of lesions was(5.43±2.03)cm.For the largest lesion(target lesion)in 18 cases,5(5/18,27.78％)were found with very low echo,11(11/18,61.11％)with low echo and 2(2/18,11.11％)with mixed echo.The internal echo was uneven in 10 lesions(10/18,55.56％)while uniform in 8 lesions(8/18,44.44％),8(8/18,44.44％)shaped regularly but 10(10/18,55.56％)irregularly,15(15/18,83.33％)with clear and 3(3/18,16.67％)with unclear boundaries.CDFI showed blood flow signals in 10(10/18,55.56％)but not in 8 lesions(8/18,44.44％).During CEUS of 18 target lesions,no enhancement was detected in 1 lesion(1/18,5.56％),peripheral to central enhancement,central to peripheral enhancement and synchronous enhancement was observed in 12(12/18,66.67％),2(2/18,11.11％)and 3 lesions(3/18,16.67％),respectively,which at the peak mainly presented as low(8/18,44.44％)or high(7/18,38.89％)enhancement,while no enhancement or equal enhancement was noticed in 1(1/18,5.56％)and 2(2/18,11.11％)lesions,respectively.Uniform and uneven distribution of contrast agents was found in 5(5/18,27.78％)and 12(12/18,66.67％)lesions,respectively,while 1 lesion(1/18,5.56％)without distribution of contrast agents.Annular and dendritic enhancement in peripheral area was observed in 7(7/18,38.89％)and 5 lesions(5/18,27.78％),while nodular enhancement(3/18,16.67％)or no enhancement(3/18,16.67％)was noticed each in 3 lesions.The scope enlarged after enhancement in 1 lesion(1/18,5.56％),while 17 lesions(17/18,94.44％)did not increase significantly.In the late stage of enhancement,16 lesions(16/18,88.89％)showed low enhancement,while 2(2/18 11.11％)showed no enhancement.Among 18 target lesions,CEUS showed blood supply in 17 lesions(17/18,94.44％),while no blood supply was found in 1 lesion(1/18,5.56％).CEUS correctly diagnosed 11 cases of splenic lymphoma,with diagnostic accuracy of 61.11％(11/18),higher than that of conventional ultrasound([4/18,22.22％],P=0.020).Conclusion CEUS had important clinical value for diagnosing splenic lymphoma.

Objective:To analyze the electrocardiogram (ECG) data of congenital long QT syndrome (LQTS) patients, and to identify the ECG parameters for prediction of life-threatening arrhythmic events (LAEs).Methods:This cohort study enrolled patients diagnosed with congenital LQTS at the Department of Cardiology, Beijing Tsinghua Changgung Hospital from September 2014 to May 2023. Baseline clinical and ECG data were collected. Patients were followed with LAEs as the primary endpoint. Based on the occurrence of LAEs, patients were divided into two groups: the event group and the event-free group. Cox regression analysis was used to identify independent predictors of LAEs in LQTS patients.Results:A total of 293 patients diagnosed with congenital LQTS were included, aged 32.5 (19.0, 41.8) years, including 201 females (68.6%). Sixty-six patients experienced LAEs and 227 patients did not. Compared to the event-free group, the event group had a younger onset age (13.0 (5.5, 20.5) years vs. 26.0 (13.0, 35.0) years), a slower heart rate (69.0 (59.5, 76.5) beats/min vs. 77.0 (67.0, 88.0) beats/min), a higher proportion with family history of sudden cardiac death (30.3% vs. 14.5%), as well as longer QT intervals (500.0 (467.0, 594.0) ms vs. 428.0 (402.0, 470.0) ms) and QTc intervals (544.0 (502.5, 589.0) ms vs. 489.0 (480.0, 504.0) ms). Additionally, the event group had higher peak T-wave alternans value (65.0 (42.5, 85.3) μV vs. 44.0 (36.0, 54.0) μV), a higher proportion of patients with documented torsades de pointes (TdP) or ventricular fibrillation (VF) on 24-hour Holter monitoring (39.3% vs. 4.9%), and higher rates of pharmacological treatment (100.0% vs. 9.7%) and device therapy or left cardiac sympathetic denervation (45.5% vs. 2.2%) (all P<0.05). Multivariate Cox regression analysis identified that the heart rate<60 beats/min ( HR=2.0, 95% CI: 1.0-3.7) and QTc interval ≥500 ms ( HR=2.9, 95% CI: 1.5-5.6) on 12-lead ECG, as well as peak T-wave alternans value ≥55.5 μV ( HR=3.2, 95% CI: 1.3-7.8) and documented TdP or VF ( HR=2.0, 95% CI: 1.1-3.7) on 24-hour Holter monitoring were independent predictors of LAEs in LQTS patients (all P<0.05). Conclusion:Heart rate <60 beats/min and QTc interval ≥500 ms on 12-lead ECG, along with peak T-wave alternans value ≥55.5 μV and documented TdP or VF on 24-hour Holter monitoring, have been identified as independent predictors of LAEs in patients with LQTS. These ECG parameters may serve as valuable early indicators of sudden cardiac death in LQTS patients.

Objective:To investigate the prevalence and severity of symptom burden among long-term survivors of oropharyngeal cancer after radiotherapy, to identify core symptom clusters, and to explore their correlation with quality of life.Methods:A previous retrospective study was conducted by the Cancer Hospital, Chinese Academy of Medical Sciences on patients with oropharyngeal cancer who underwent radiotherapy between January 2010 and December 2020. Patients who were still alive as of December 2023 were further followed and analyzed. From December 2023 to August 2024, symptom burden and quality of life were assessed using the Chinese version of the MD Anderson Symptom Inventory–Head and Neck Module (MDASI-HN) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ). Exploratory factor analysis (principal component analysis with Promax rotation) were used to identify symptom clusters. Spearman correlation analysis was performed to explore the relationship between total symptom cluster scores and standardized domain scores of quality of life. Multivariate linear regression analysis was further employed to determine the relationship between identified symptom clusters and overall quality of life.Results:A total of 273 patients were included, with a median follow-up duration of 6.2 years (range: 3.5-14.5 years) and a median age of 61 years (range: 27-88 years) at follow-up. The top 5 incidence rates of symptom reported by patients were mucus problems in the mouth or throat (147 cases, 53.8%), dental or gum issues (143 cases, 52.4%), xerostomia (140 cases, 51.3%), difficulty swallowing or chewing (95 cases, 34.8%), and taste disturbance (79 cases, 28.9%). Among them, xerostomia was the most serious symptom. The most frequently reported interference was impact on work (including household chores) (55 cases, 20.1%). Exploratory factor analysis identified 3 symptom clusters: fatigue-nausea cluster, eating-voice cluster, and xerostomia-sleep cluster, all of which were significantly correlated with lower overall quality of life of patients (all P<0.001). Conclusion:Long-term survivors of oropharyngeal cancer after radiotherapy experience substantial symptom burden. The fatigue-nausea, eating-voice, and xerostomia-sleep clusters are the core symptom clusters impacting quality of life.

Objective:To understand the occupational injury situation of front-line workers in metallurgical and shipbuilding and repairing industry, and explore the risk factors of occupational injury.Methods:From September 2023 to March 2024, using cluster sampling method, front-line workers from 2 metallurgical enterprises in Shaoguan and Jinan City and 2 shipbuilding and repairing enterprises in Jiangmen and Shenzhen City were selected as the investigation objects. 6248 questionnaires were distributed and collected, and 6178 were effective questionnaires, with a effective recovery rate of 98.88%. The basic information, living habits, working system, protection and occupational injury of workers were investigated, and the data of occupational injury in factories was collected. The types, jobs and main causes of occupational injuries in different industries were analyzed, and the influencing factors of occupational injuries were analyzed by univariate and multi-factor logistic regression.Results:The incidence of occupational injury was 3.13% (128/4086) in metallurgical industry and 4.02% (84/2092) in shipbuilding and repairing industry. The top three occupational injuries in the metallurgical industry were furnace worker (17.19%, 22/128), steel rolling worker (14.84%, 19/128), maintenance worker (10.16%, 13/128), and the top three injury types were mechanical injury (24.22%, 31/128), height fall (20.31%, 26/128) and object strikes (17.97%, 23/128). The top three occupational injuries in shipbuilding and repairing industry were welder (20.24%, 17/84), riveter (9.52%, 8/84) and crane (8.33%, 7/84). The top three injury types were hit by objects (34.52%, 29/84), hit by falling objects (22.62%, 19/84), and lifting injury (20.24%, 17/84). The injuries of workers in metallurgical industry and shipbuilding and repairing industry were mainly fractures, accounting for 32.03% (41/128) and 60.71% (51/84), respectively. The incidence of occupational injury was higher in males, with sleep disorder, high temperature exposure and chemical toxicity exposure ( P<0.05). There were significant differences in age, smoking degree, working age and emotional state between workers with occupational injury and those without occupational injury ( P<0.05). Multivariate analysis showed that male, age above 50 years old, moderate smoking, working years of 5-9 years, mild anxiety, poor health status and high temperature exposure were risk factors for occupational injury ( OR=25.57, 3.72, 14.27, 2.09, 1.50, 4.36, 0.66, P<0.05) . Conclusion:The incidence of occupational injury is higher in shipbuilding and repairing industry, and fracture is the main type of occupational injury. The occurrence of occupational injury is affected by gender, age, smoking, working age, emotional state, health status and high temperature exposure.

Oral cancer is a malignant tumor with poor incidence and prognosis among primary head and neck tumors, and postoperative patients are often combined with surgical scar, dysphagia, mastication difficulties, and speech dysfunction, which bring heavy physiological and psychological burdens to the patients, and make their reintegration into the society after cancer generally poorly adapted. Factors such as patients′ role transition, swallowing function, life and social changes during treatment will affect their psychosocial adaptive function. The enhancement of psychosocial adaptive ability helps to stimulate patients′ intrinsic potential, improve their psychological state, and enable them to adapt to the changes brought by the disease, thus promoting their physical and mental health. In this paper, we review domestic and international nursing interventions such as perioperative nursing interventions, continuity nursing interventions, and cosmetic nursing to effectively improve patients′postoperative psychosocial adaptations, and provide a theoretical basis for the future development of a scientific and effective intervention program for psychosocial adaptations in oral cancer.

BACKGROUND:Ankle inversion injuries frequently occur during landing,injuring the anterior talofibular and calcaneofibular ligaments.Previous studies usually used indirect indicators,such as inversion angle,as an injury risk indicator,but epidemiological support is lacking.OBJECTIVE:To calculate anterior talofibular and calcaneofibular ligament strains using a three-dimensional multi-body foot model during a drop-landing and to investigate whether increasing the foot toe-out angle for landing would reduce the risk of inversion sprains.METHODS:Thirty-five participants with high sports demands[15 males and 20 females,age:(21.0±0.9)years,height:(176.2±8.8)cm,body mass:(71.6±12.8)kg]were recruited to perform a drop-landing test using a trapdoor device to simulate ankle inversion sprains.Two landing conditions were tested,i.e.,natural landing and toe-out landing.Kinematic data were collected using a 12-camera motion analysis system,the strains of the anterior talofibular and calcaneofibular ligaments were calculated using a three-dimensional rigid-body foot model.RESULTS AND CONCLUSION:From natural landing to toe-out landing conditions,the anterior talofibular ligament strain decreased[natural landing=(3.57±1.92)％,toe-out landing=(0.36±1.18)％,P＜0.001,Cohen's d=2.01),as was the calcaneofibular ligament strain[natural landing=(1.38±1.80)％,toe-out landing=(0.28±2.29)％,P=0.003,Cohen's d=0.81).It could be concluded that increasing foot toe-out angle reduces anterior talofibular and calcaneofibular ligament strains during drop-landing with ankle inversion,thereby reducing the potential of ankle inversion sprains.

Objective To observe the value of contrast-enhanced ultrasound(CEUS)for diagnosing splenic lymphoma.Methods Eighteen patients with pathologically confirmed splenic lymphoma were retrospectively collected.The routine ultrasound and CEUS manifestations of lesions were observed,and the diagnostic accuracy of these two methods for diagnosing splenic lymphoma were compared.Results Among 18 cases,conventional ultrasound showed single lesion in 8(8/18,44.44％)and multiple lesions in 10 cases(10/18,55.56％).The maximum diameter of lesions was(5.43±2.03)cm.For the largest lesion(target lesion)in 18 cases,5(5/18,27.78％)were found with very low echo,11(11/18,61.11％)with low echo and 2(2/18,11.11％)with mixed echo.The internal echo was uneven in 10 lesions(10/18,55.56％)while uniform in 8 lesions(8/18,44.44％),8(8/18,44.44％)shaped regularly but 10(10/18,55.56％)irregularly,15(15/18,83.33％)with clear and 3(3/18,16.67％)with unclear boundaries.CDFI showed blood flow signals in 10(10/18,55.56％)but not in 8 lesions(8/18,44.44％).During CEUS of 18 target lesions,no enhancement was detected in 1 lesion(1/18,5.56％),peripheral to central enhancement,central to peripheral enhancement and synchronous enhancement was observed in 12(12/18,66.67％),2(2/18,11.11％)and 3 lesions(3/18,16.67％),respectively,which at the peak mainly presented as low(8/18,44.44％)or high(7/18,38.89％)enhancement,while no enhancement or equal enhancement was noticed in 1(1/18,5.56％)and 2(2/18,11.11％)lesions,respectively.Uniform and uneven distribution of contrast agents was found in 5(5/18,27.78％)and 12(12/18,66.67％)lesions,respectively,while 1 lesion(1/18,5.56％)without distribution of contrast agents.Annular and dendritic enhancement in peripheral area was observed in 7(7/18,38.89％)and 5 lesions(5/18,27.78％),while nodular enhancement(3/18,16.67％)or no enhancement(3/18,16.67％)was noticed each in 3 lesions.The scope enlarged after enhancement in 1 lesion(1/18,5.56％),while 17 lesions(17/18,94.44％)did not increase significantly.In the late stage of enhancement,16 lesions(16/18,88.89％)showed low enhancement,while 2(2/18 11.11％)showed no enhancement.Among 18 target lesions,CEUS showed blood supply in 17 lesions(17/18,94.44％),while no blood supply was found in 1 lesion(1/18,5.56％).CEUS correctly diagnosed 11 cases of splenic lymphoma,with diagnostic accuracy of 61.11％(11/18),higher than that of conventional ultrasound([4/18,22.22％],P=0.020).Conclusion CEUS had important clinical value for diagnosing splenic lymphoma.

Extensive studies have identified potential adverse effects on semen quality of obesity, based on body mass index, but the association between body fat distribution, a more relevant indicator for obesity, and semen quality remains less clear. We conducted a longitudinal study of 4304 sperm donors from the Guangdong Provincial Human Sperm Bank (Guangzhou, China) during 2017-2021. A body composition analyzer was used to measure total and local body fat percentage for each participant. Generalized estimating equations were employed to assess the association between body fat percentage and sperm count, motility, and morphology. We estimated that each 10% increase in total body fat percentage (estimated change [95% confidence interval, 95% CI]) was significantly associated with a 0.18 × 10 6 (0.09 × 10 6 -0.27 × 10 6 ) ml and 12.21 × 10 6 (4.52 × 10 6 -19.91 × 10 6 ) reduction in semen volume and total sperm count, respectively. Categorical analyses and exposure-response curves showed that the association of body fat distribution with semen volume and total sperm count was stronger at higher body fat percentages. In addition, the association still held among normal weight and overweight participants. We observed similar associations for upper limb, trunk, and lower limb body fact distributions. In conclusion, we found that a higher body fat distribution was significantly associated with lower semen quality (especially semen volume) even in men with a normal weight. These findings provide useful clues in exploring body fat as a risk factor for semen quality decline and add to evidence for improving semen quality for those who are expected to conceive.
Humans ; Male ; Adult ; Semen Analysis ; China ; Body Fat Distribution ; Longitudinal Studies ; Sperm Count ; Sperm Motility ; Body Mass Index ; Tissue Donors ; Obesity/complications* ; Spermatozoa ; Young Adult ; Middle Aged ; East Asian People