Objective To study the relationships between Helicobacter pylori(Hp)infection and the occurrence of osteoporosis via Meta-analysis.Methods Two researchers independently retrieved related literature related to the association between Hp infection and osteoporosis and published in such databases as PubMed,EMBASE and Cochrane Library,China Science and Technology Journal Database,China National Knowledge Infrastructure(CNKI),and Wanfang Database as of February 2024.STATA 11.0 software was used for Meta-analysis before the combined OR value and its 95％CI were calculated.Results Twenty-four studies involving 24 936 participants were included in the study.Meta-analysis showed that Hp infection was significantly associated with the risk of osteoporosis(OR:1.52,95％CI:1.17-1.99).Those infected with the CagA-positive Hp strain were more likely to develop osteoporosis(OR:2.42,95％CI:1.32-4.43).Hp infection was significantly associated with decreased bone mass(OR=1.32,95％CI:1.08-1.62),but the decrease of bone mineral density in Hp-positive patients was not significant compared with Hp negative controls.Conclusion Infection with Hp,particularly the CagA-positive strain,has been associated with an increased risk of osteoporosis.The bone health of Hp-positive patients deserves more attention.