Objective To investigate the levels of vascular endothelial growth factor(VEGF)and vas-cular endothelial growth factor receptor 2(VEGFR2)in serum and urine of the children patients with primary nephrotic syndrome(PNS),and to conduct the correlation analysis on the experimental indexes of 24 h urine protein quantitation,blood albumin(ALB),total cholesterol(TC),blood urea nitrogen(BUN)and creatinine(Scr).Methods Thirty children patients with PNS without hormone treatment admitted and treated in this hospital from January 2020 to December 2023 were selected as the study subjects and divided into the hormone sensitive nephrotic syndrome(SSNS)group(n=12)and steroid dependent nephrotic syndrome(SDNS)group(n=18)according to the cortical hormone treatment effect.Twenty healthy children with matched age and sex visiting in the pediatric department during the same period served as the control group.The differ-ences of VEGF and VEGFR2 levels in blood and urine were compared among 3 groups and their correlation with the experimental indexes was analyzed.Results Compared with the control group,the blood VEGF lev-el,urine VEGF and BUN levels in the SDNS group were increased,blood VEGFR2 and urine VEGFR2,24 h urine protein quantitation and TC level in the SSNS group and SDNS group were increased,the ALB level was decreased,and the differences were statistically significant(P<0.05).The Pearson correlation analysis re-sults showed that blood VEGF level was positively correlated with the 24 h urine protein quantitation and TC level,and negatively correlated with the ALB level(P<0.05);the urine VEGF level was positively correlated with 24 urine protein quantitation and TC level,and negatively correlated with the Scr level(P<0.05);blood VEGF2 level was positively correlated with the 24 h urine protein quantitation and the TC level,and negative-ly correlated with the ALB level(P<0.05);the urine VEGF2 level was positively correlated with the 24 h u-rine protein quantitation and TC level,and negatively correlated with the ALB level(P<0.05).Conclusion The blood and urine VEGF and VEGFR2 may serve as the novel indicators for the early diagnosis,prediction and hormone sensitivity evaluation in the children patients with PNS.

The paper probed into the reform of healthcare personnel′s payroll system , identifying such problems as the staffing quota management system curbing rational flow of healthcare personnel ,lack of enthusiasm of such personnel ,delayed progress of the implementation of the occupational pension and the shortage of talents in urgent need.With current outcomes confirmed ,the authors recommended to remove the staffing quota system and introduce a market mechanism ;to build an income growth mechanism for higher incentives ;to enhance primary institutions′team building ,and develop talents in urgent need ;to unify social insurance standards and enhance local fiscal support .

Objective:To investigate the incidence of photo‐allergic contact dermatitis (PACD)induced by chlorpromazine and sulfanilamide with photo‐patch testing (PPT ) .Methods :Patients who underwent PPT for suspected photo dermatoses in Huashan Hospital ,Fudan University from January 2006 to December 2012 were selected .PPT results were evaluated with the criteria of International Contact Dermatitis Research Group (ICDRG) .Photoallergic positive rate was compared between two allergen groups .And the photoallergic positive rate of each allergen was compared among different genders and ages .Results:A total of 4836 patients were enrolled .PACD positive rate was 44 .3% in 3993 subjects tested with chlorpromazine and 6 .9% in 4836 subjects tested with sulfanilamide .There was a significant difference between the two groups (P<0 .0001) .In the 3993 subjects tested with chlorpromazine ,the male PACD positive rate was 43 .6% ,while the female positive rate was 44 .7% ,and there was no statistical significance(P=0 .51) .In the 4836 subjects tested with sulfanilamide ,the male PACD positive rate was 9 .3% while the female positive rate was 5 .4% ,and there was a significant difference(P<0 .0001) .The PACD positive rate increased with age in subjects tested with chlorpromazine and there was significant difference among different ages ( P< 0 . 0001) .The PACD positive rate in subjects tested with sulfanilamide showed no statistical significance among different ages (P=0 .37) .Conclusions :Chlorpromazine presents higher PACD positive rate than sulfanilamide .The PACD of chlorpromazine mainly happens in middle‐aged and elderly people .The PACD positive rate of sulfanilamide in males is higher than that in females .