Background/Introduction: As the world face health-system shocks from COVID-19, Obstetrician-Gynecologists become perplexed by the uncertainties these bring to the vulnerable pregnant and gynecologic population. The country's capacity for diagnosis via RTPCR consists of only a tiny proportion of the population. With the intent of coming up with a less expensive fast point of care test kits, antibody-based lateral flow assays were developed. Aims and Objectives: Determine the diagnostic accuracy of a lateral flow immunoassay for the detection IgM/IgG antibodies to SARS-CoV2 using RT-PCR as gold standard among symptomatic and asymptomatic high risk OBGYN population. Materials and Methods: This is a multicenter cross-sectional prospective study performed on 147 asymptomatic and symptomatic high risk OBGYN patients who underwent both RTPCR and RAT. Test results were entered using a two by two table to compute for the sensitivity (Sn), specificity (Sp), positive and negative predictive value (PPV/NPV), likelihood ratios (LR) comparing RT-PCR with IgM/IgG using Medcalc statistical software. Results: The RAT for IgG/IgM was not found to be sensitive in both groups. It was able to identify only one of the five patients who had COVID-19 based on RT-PCR. Moreover, the (PPV) was found to be only 20% since only one patient tested positive in the RAT for IgM/IgG that was also positive in the RT-PCR. The (LR+ and LR-) for the symptomatic group was close to 1 implying a slightly higher probability of a true positive compared to that of a false positive test and a negative test result given the absence of the disease respectively. (Sp) and (NPV) of the RAT for IgM/IgG is high for both groups. This means that RAT for IgM/IgG does well in identifying patients who truly do not have COVID-19. Conclusion With a very low sensitivity of 5% in this study, RAT for COVID-19 cannot be used for screening purposes.
Pregnancy

<p style="text-align: justify;">Leiomyosarcoma of the vagina is extremely rare. Incidence occurs in 2%-3% of the uncommon vaginal malignancies. Its timely diagnosis is crucial since any delay would preclude treatment usually leading to advanced grade of the leiomyosarcoma. We are presented with a case of a 40 year old. G1P1 (1001) with a 5 month history of vaginal bleeding associated with anorexia, weight loss and a 5cm x 3cm solid, firm mass at the left posterolateral wall of the vagina. Diagnostic examinations including CT scan, colposcopy, immunostaining were done to rule out differentials for a solid mass in the vaginal canal. She underwent wide excision of the mass and repair  of the rectovaginal defect. Histopathologic evidence showed high grade sarcoma particularly a leiomyosarcoma. Postoperatively, she regained her sexual function, restored her lower genital tract anatomy and reaffirmed her self esteem. Close follow-up with radiotherapy was then recommended as the individualized management in this rare type of malignancy.p>
Human ; Female ; Adult ; Leiomyosarcoma ; Colposcopy ; Anorexia ; Weight Loss ; Vaginal Neoplasms ; Tomography, X-ray Computed

<p style="text-align: justify;">BACKGROUND: The use of metformin in gestational diabetes mellitus (GDM) has become increasingly accepted but clinical practice is ahead of the evidence. A wide range of metabolic and reproductive benefits have been reported from non-randomized trials with Metformin.
METHODS: Of the 107 women enrolled in the randomized controlled study,53 women were assigned to the Metformin group and 54 to the Insulin group. Only 30 women completed the Metformin arm and 42 completed the Insulin arm of the study. The ideal analysis was to perform evaluation according to the intention to treat principle on the desired number of population. However, there was a decreasing trend in the number of admissions of GDM patients as compared to the average of 167.5 in the Philippine General Hospital.
RESULTS: The maternal outcome of fasting blood glucose
Human ; Blood Glucose ; Diabetes, Gestational ; Insulin ; Metformin ; Glucose ; Premature Birth ; Fasting ; Hypoglycemia ; Postprandial Period