At present, enteral nutrition is well used in the management of patients with severe acute pancreatitis, and feeding intolerance is a common phenomenon in patients with severe acute pancreatitis during the process of enteral nutrition. Through literature review, this article summarizes the timing, route, preparation type of enteral nutrition in patients with severe acute pancreatitis and the influencing factors, prevention and treatment measures of enteral nutrition feeding intolerance at home and abroad, so as to provide a reference for the prevention of enteral nutrition feeding intolerance in patients with severe acute pancreatitis.