Objective:To systematically evaluate and synthesize qualitative studies on the illness experience of patients with heart failure, in order to inform the development of targeted health management and care strategies to improve patients' quality of life.Methods:A comprehensive literature search was conducted in PubMed, Web of Science, Embase, Cochrane Library, Wanfang Database, China National Knowledge Infrastructure, VIP Database, and China Biology Medicine disc from inception to January 31, 2025. Relevant qualitative studies on the illness experience of patients with heart failure were retrieved. Quality appraisal and data extraction were performed, and Meta-synthesis methods were used to integrate the findings.Results:A total of 12 studies were included, all of which were rated as grade B in quality appraisal. From these studies, 52 distinct findings were extracted and grouped into 10 new categories. These were further synthesized into 4 integrated themes: multidimensional decline in physical, psychological, and social functioning; increased need for support systems; negative experiences with disease perception and self-management; diverse strategies for disease acceptance and coping.Conclusions:The illness experience of heart failure patients is multidimensional. Medical staff should pay close attention to their physical, psychological, and social needs and adopt a patient-centered care model to deliver personalized and dynamic healthcare, thereby improving quality of life and clinical outcomes.

Objective To observe right heart function in degenerative mitral regurgitation(DMR)and functional mitral regurgitation(FMR)patients based on two-dimensional speckle tracking imaging(2D-STI)and real-time three dimensional echocardiography(RT-3DE).Methods Thirty cases of DMR(DMR group),30 cases of(FMR group)and 30 healthy subjects(control group)were prospectively enrolled.Routine ultrasound parameters,right ventricular 2D-STI and RT-3DE parameters were compared among 3 groups and between each 2 groups.Results Significant differences of tricuspid annular plane systolic excursion(TAPSE),fractional area change(FAC),pulmonary artery systolic pressure(PASP),right ventricular end systolic volume(RVESV),right ventricular stroke volume(RVSV),right ventricular ejection fraction(RVEF),left ventricular ejection fraction(LVEF)and tricuspid regurgitation effective regurgitant orifice area(TR-EROA)were found among 3 groups(all P＜0.05).Compared with control group,TAPSE decreased but PASP increased in DMR and FMR groups(all P＜0.05),and significant differences of TAPSE,FAC,PASP,RVESV,RVSV,RVEF,LVEF and TR-EROA were noticed between DMR group and FMR group(all P＜0.05).Significant differences of right ventricular global longitudinal strain(RVGLS),right ventricular free wall longitudinal strain(RVFWLS),longitudinal strain of 3 segments of right ventricular free wall,as well as of right ventricular pulmonary artery(RVPA)coupling parameters were found among 3 groups and between each 2 groups(all P＜0.05).Significant differences of RT-3DE-RVESV,RT-3DE-RVSV and RT-3DE-RVEF were found among 3 groups(all P＜0.05)and between FMR group and the other 2 groups(all P＜0.05).Conclusion Compared with DMR,right heart function changed more significantly in FMR patients.

Prostate cancer (PCa) ranks as the second most prevalent malignancy among men worldwide. Early diagnosis, personalized treatment, and prognosis prediction of PCa play a crucial role in improving patients' survival rates. The advancement of artificial intelligence (AI), particularly the utilization of deep learning (DL) algorithms, has brought about substantial progress in assisting the diagnosis, treatment, and prognosis prediction of PCa. The introduction of the foundation model has revolutionized the application of AI in medical treatment and facilitated its integration into clinical practice. This review emphasizes the clinical application of AI in PCa by discussing recent advancements from both pathological and imaging perspectives. Furthermore, it explores the current challenges faced by AI in clinical applications while also considering future developments, aiming to provide a valuable point of reference for the integration of AI and clinical applications.
Humans ; Prostatic Neoplasms/diagnosis* ; Male ; Artificial Intelligence ; Deep Learning ; Prognosis

Objective:To investigate the efficacy of using a single Kocher-Langenbeck approach to improve anterior column screw fixation for the treatment of transverse + posterior wall acetabular fractures.Method:A retrospective analysis was conducted of the data of 21 patients who had been treated with a single Kocher-Langenbeck approach to improve anterior column screw fixation for transverse + posterior wall acetabular fractures at Department of Orthopaedics, Weifang People's Hospital from May 2021 to May 2023. There were 11 males and 10 females with an age of (51.3±15.5) years. The time from injury to surgery was (10.4±3.6) days. The anterior column screw fixation was improved as follows: screws were implanted 1 to 2 cm in front of the apex of the great notch of the external iliac plate of the pelvis to penetrate out at the upper branch root of the pubic ramus, with the whole screw fully located within the bony channel. Such indexes were recorded as surgical time, intraoperative blood loss, intraoperative fluoroscopy frequency for improved placement of anterior column screws, fracture healing time, incidence of complications, and fracture reduction and hip joint function at the last follow-up.Results:For this cohort, surgical time was (120.9±40.7) minutes, intraoperative blood loss (330.2±65.9) mL, and intraoperative fluoroscopy frequency for improved placement of anterior column screws (6.2±2.3) times. The 21 patients were followed up for (21.5±5.9) months. All fractures achieved bony union after (3.2±1.1) months. Incision fat liquefaction occurred in 1 patient after surgery and symptoms of sciatic nerve injury were observed in 2 patients. Follow-ups observed no such complications as loosening or breakage of internal fixators. According to the Matta scoring criteria, the quality of fracture reduction at the last follow-up was evaluated as anatomical reduction in 15 cases, as satisfactory reduction in 4 cases, as acceptable reduction in 2 cases, giving a satisfaction rate of 90.5% (19/21). According to the improved Merle d'Aubigné & Poster scoring criteria, hip function was evaluated as excellent in 16 cases, as good in 2 cases, and as fair in 3 cases, giving an excellent and good rate of 85.7% (18/21).Conclusion:It is effective to use a single Kocher-Langenbeck approach to improve anterior column screw fixation for the treatment of transverse + posterior wall acetabular fractures, showing advantages of reduced surgical time and intraoperative bleeding.

Objective:To systematically evaluate and synthesize qualitative studies on the illness experience of patients with heart failure, in order to inform the development of targeted health management and care strategies to improve patients' quality of life.Methods:A comprehensive literature search was conducted in PubMed, Web of Science, Embase, Cochrane Library, Wanfang Database, China National Knowledge Infrastructure, VIP Database, and China Biology Medicine disc from inception to January 31, 2025. Relevant qualitative studies on the illness experience of patients with heart failure were retrieved. Quality appraisal and data extraction were performed, and Meta-synthesis methods were used to integrate the findings.Results:A total of 12 studies were included, all of which were rated as grade B in quality appraisal. From these studies, 52 distinct findings were extracted and grouped into 10 new categories. These were further synthesized into 4 integrated themes: multidimensional decline in physical, psychological, and social functioning; increased need for support systems; negative experiences with disease perception and self-management; diverse strategies for disease acceptance and coping.Conclusions:The illness experience of heart failure patients is multidimensional. Medical staff should pay close attention to their physical, psychological, and social needs and adopt a patient-centered care model to deliver personalized and dynamic healthcare, thereby improving quality of life and clinical outcomes.

Objective:To investigate the current status of treatment inertia in patients with chronic heart failure who were readmitted to hospitals, and to explore the influencing factors of treatment inertia in patients with chronic heart failure, so as to provide a basis for patients to provide effective and timely rehabilitation treatment.Methods:Using the phenomenological research method, 16 readmitted chronic heart failure patients from Shandong Provincial Hospital Affiliated to Shandong First Medical University, Qilu Hospital of Shandong University and the First Affiliated Hospital of Shandong First Medical University were selected by purpose sampling method from May to July 2024 for semi-structured interview; the interview data were analyzed and summarized by Colaizzi seven-step analysis method.Results:There were 12 males and 4 females, aged (60.63 ± 9.39) years old. There were three themes: behavioral characteristics of treatment inertia (including delayed initiation of treatment, refusal to upgrade treatment, poor treatment compliance); internal barriers of treatment inertia (including insufficient symptom perception, multiple pressures of patients, insufficient confidence in treatment); external influences of treatment inertia (including insufficient family support and limited medical resources).Conclusions:Treatment inertia is common in patients with chronic heart failure who are readmitted to the hospital, which leads to the diversification of influencing factors of treatment inertia and negatively affects the treatment effect of patients. Medical staff should conduct targeted analysis and treatment according to the specific situation of the patient, reduce the inertia of the patient′s treatment, promote the timely treatment of patients with chronic heart failure, actively cooperate with the treatment, and improve the patient′s recovery effect.

Objective:To investigate the current status of treatment inertia in patients with chronic heart failure who were readmitted to hospitals, and to explore the influencing factors of treatment inertia in patients with chronic heart failure, so as to provide a basis for patients to provide effective and timely rehabilitation treatment.Methods:Using the phenomenological research method, 16 readmitted chronic heart failure patients from Shandong Provincial Hospital Affiliated to Shandong First Medical University, Qilu Hospital of Shandong University and the First Affiliated Hospital of Shandong First Medical University were selected by purpose sampling method from May to July 2024 for semi-structured interview; the interview data were analyzed and summarized by Colaizzi seven-step analysis method.Results:There were 12 males and 4 females, aged (60.63 ± 9.39) years old. There were three themes: behavioral characteristics of treatment inertia (including delayed initiation of treatment, refusal to upgrade treatment, poor treatment compliance); internal barriers of treatment inertia (including insufficient symptom perception, multiple pressures of patients, insufficient confidence in treatment); external influences of treatment inertia (including insufficient family support and limited medical resources).Conclusions:Treatment inertia is common in patients with chronic heart failure who are readmitted to the hospital, which leads to the diversification of influencing factors of treatment inertia and negatively affects the treatment effect of patients. Medical staff should conduct targeted analysis and treatment according to the specific situation of the patient, reduce the inertia of the patient′s treatment, promote the timely treatment of patients with chronic heart failure, actively cooperate with the treatment, and improve the patient′s recovery effect.

Objective To observe right heart function in degenerative mitral regurgitation(DMR)and functional mitral regurgitation(FMR)patients based on two-dimensional speckle tracking imaging(2D-STI)and real-time three dimensional echocardiography(RT-3DE).Methods Thirty cases of DMR(DMR group),30 cases of(FMR group)and 30 healthy subjects(control group)were prospectively enrolled.Routine ultrasound parameters,right ventricular 2D-STI and RT-3DE parameters were compared among 3 groups and between each 2 groups.Results Significant differences of tricuspid annular plane systolic excursion(TAPSE),fractional area change(FAC),pulmonary artery systolic pressure(PASP),right ventricular end systolic volume(RVESV),right ventricular stroke volume(RVSV),right ventricular ejection fraction(RVEF),left ventricular ejection fraction(LVEF)and tricuspid regurgitation effective regurgitant orifice area(TR-EROA)were found among 3 groups(all P＜0.05).Compared with control group,TAPSE decreased but PASP increased in DMR and FMR groups(all P＜0.05),and significant differences of TAPSE,FAC,PASP,RVESV,RVSV,RVEF,LVEF and TR-EROA were noticed between DMR group and FMR group(all P＜0.05).Significant differences of right ventricular global longitudinal strain(RVGLS),right ventricular free wall longitudinal strain(RVFWLS),longitudinal strain of 3 segments of right ventricular free wall,as well as of right ventricular pulmonary artery(RVPA)coupling parameters were found among 3 groups and between each 2 groups(all P＜0.05).Significant differences of RT-3DE-RVESV,RT-3DE-RVSV and RT-3DE-RVEF were found among 3 groups(all P＜0.05)and between FMR group and the other 2 groups(all P＜0.05).Conclusion Compared with DMR,right heart function changed more significantly in FMR patients.

Objective:To investigate the efficacy of using a single Kocher-Langenbeck approach to improve anterior column screw fixation for the treatment of transverse + posterior wall acetabular fractures.Method:A retrospective analysis was conducted of the data of 21 patients who had been treated with a single Kocher-Langenbeck approach to improve anterior column screw fixation for transverse + posterior wall acetabular fractures at Department of Orthopaedics, Weifang People's Hospital from May 2021 to May 2023. There were 11 males and 10 females with an age of (51.3±15.5) years. The time from injury to surgery was (10.4±3.6) days. The anterior column screw fixation was improved as follows: screws were implanted 1 to 2 cm in front of the apex of the great notch of the external iliac plate of the pelvis to penetrate out at the upper branch root of the pubic ramus, with the whole screw fully located within the bony channel. Such indexes were recorded as surgical time, intraoperative blood loss, intraoperative fluoroscopy frequency for improved placement of anterior column screws, fracture healing time, incidence of complications, and fracture reduction and hip joint function at the last follow-up.Results:For this cohort, surgical time was (120.9±40.7) minutes, intraoperative blood loss (330.2±65.9) mL, and intraoperative fluoroscopy frequency for improved placement of anterior column screws (6.2±2.3) times. The 21 patients were followed up for (21.5±5.9) months. All fractures achieved bony union after (3.2±1.1) months. Incision fat liquefaction occurred in 1 patient after surgery and symptoms of sciatic nerve injury were observed in 2 patients. Follow-ups observed no such complications as loosening or breakage of internal fixators. According to the Matta scoring criteria, the quality of fracture reduction at the last follow-up was evaluated as anatomical reduction in 15 cases, as satisfactory reduction in 4 cases, as acceptable reduction in 2 cases, giving a satisfaction rate of 90.5% (19/21). According to the improved Merle d'Aubigné & Poster scoring criteria, hip function was evaluated as excellent in 16 cases, as good in 2 cases, and as fair in 3 cases, giving an excellent and good rate of 85.7% (18/21).Conclusion:It is effective to use a single Kocher-Langenbeck approach to improve anterior column screw fixation for the treatment of transverse + posterior wall acetabular fractures, showing advantages of reduced surgical time and intraoperative bleeding.

Objective:To investigate the clinical features and prognosis of male with anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody.Methods:The clinical data of 246 patients with DM and anti-MDA5 autoantibodies hospitalized by Jiangsu Myositis Cooperation Group from 2017 to 2020 were collected and retrospectively analyzed. Chi-square test was performed to compared between counting data groups; Quantitative data were expressed by M ( Q1, Q3), and rank sum test was used for comparison between groups; Single factor survival analysis was performed by Kaplan-Meier method and Log rank test; Cox regression analysis were used for multivariate survival analysis. Results:①The male group had a higher proportion of rash at the sun exposure area [67.1%(47/70) vs 52.8%(93/176), χ2=4.18, P=0.041] and V-sign [50.0%(35/70) vs 30.7%(54/176), χ2=8.09, P=0.004] than the female group. The male group had higher levels of creatine kinase [112(18, 981)U/L vs 57 (13.6, 1 433)U/L, Z=-3.50, P<0.001] and ferritin [1 500 (166, 32 716)ng/ml vs 569 (18, 14 839)ng/ml, Z=-5.85, P<0.001] than the female group. The proportion of ILD [40.0%(28/70) vs 59.7%(105/176), χ2=7.82, P=0.020] patients and the red blood cell sedimentation rate[31.0(4.0, 101.5)mm/1 h vs 43.4(5.0, 126.5)mm/1 h, Z=-2.22, P=0.026] in the male group was lower than that of the female group, but the proportion of rapidly progressive interstitial lung disease (PR-ILD) [47.1%(33/70) vs 31.3%(55/176), χ2=5.51, P=0.019] was higher than that of the female group. ②In male patients with positive anti-MDA5 antibodies,the death group had a shorter course of disease[1.0(1.0, 3.0) month vs 2.5(0.5,84) month, Z=-3.07, P=0.002], the incidence of arthritis [16.7%(4/24) vs 42.2%(19/45), χ2=4.60, P=0.032] were low than those in survival group,while aspartate aminotransferase (AST)[64(22.1, 565)U/L vs 51(14,601)U/L, Z=-2.42, P=0.016], lactate dehydrogenase (LDH) [485(24,1 464)U/L vs 352(170, 1 213)U/L, Z=-3.38, P=0.001], C-reactive protein (CRP) [11.6(2.9, 61.7) mg/L vs 4.95(0.6, 86.4) mg/L, Z=-1.96, P=0.050], and ferritin levels [2 000(681, 7 676) vs 1 125 (166, 32 716)ng/ml, Z=-3.18, P=0.001] were higher than those in the survival group, and RP-ILD [95.8%(23/24) vs 22.2%(10/45), χ2=33.99, P<0.001] occurred at a significantly higher rate. ③Cox regression analysis indicated that the course of disease LDH level, and RP-ILD were related factors for the prognosis of male anti-MDA5 antibodies [ HR (95% CI)=0.203(0.077, 0.534), P=0.001; HR (95% CI)=1.002(1.001, 1.004), P=0.003; HR (95% CI)=95.674 (10.872, 841.904), P<0.001]. Conclusion:The clinical manifestations of male anti-MDA5 antibody-positive patients are different from those of female. The incidence of ILD is low, but the proportion of PR-ILD is high. The course of disease, serum LDH level, and RP-ILD are prognostic factors of male anti-MDA5 antibody-positive patients.