Arachidonic acid can be transformed into a variety of metabolites that trigger an inflammatory response through cyclooxygenase, lipoxygenase, cytochrome P450 enzymes, and other metabolic pathways. Moreover, it plays a key role in the occurrence and development of inflammatory diseases. In recent years, multi-target drugs based on the arachidonic acid metabolic pathway have become an important direction of anti-inflammatory drug research. This article summarizes the opportunities and challenges of arachidonic acid metabolic pathways as well as their interference in the development of anti-inflammatory drugs, reviews the research progress of multi-target drug design, synthesis, and anti-inflammatory activity based on the arachidonic acid metabolic pathway, and discusses the difficulties and prospects of multi-target drugs based on metabolic pathways in anti-inflammatory drug development, aiming to provide some reference and inspiration for the study of multi-target anti-inflammatory drugs based on the arachidonic acid metabolic pathway.

Objective To prepare a novel loaded NdFeB and Fe3O4 liquid-solid phase inversion poly (polylactic-co-glycolic acid,PLGA) in situ implant (PLGA 60％ NdFeB-20％ Fe3O4) for ultrasound-guided intratumoral injection,and to investigate its intensity of magnetism and therapeutic efficiency of nude mice bearing MDA-MB-231 breast cancer.Methods PLGA-60 ％ NdFeB-20 ％ Fe3O4 in situ implant was prepared.The microstructure of PLGA-60 ％ NdFeB-20 ％ Fe3O4 was tested with scanning electron microscope (SEM).Magnetometer was used to qualify the intensity of magnetism.For the in vitro assay,60 μl solid PLGA-60％ NdFeB-20％ Fe3O4 implant was put in the center of the electromagnetic induction heating coil.Infrared thermal video of the tubes was simultaneously recorded.The size of 2 cm × 2 cm× 2 cm fresh ex vivo bovine liver was prepared,and then 60 μl PLGA-60％ NdFeB-20％ Fe3O4 was injected into it.Similarly,ex vivo bovine liver was heated by the above intermittent time for 1,2,3,4 minutes,respectively,and the ablation volume was calculated.Finally,nude mice were equally divided into treatment group and control group.Mice in treatment group were discontinuously heated for 3 min after being injected with the above mentioned implant,while CEUS was performed before and after heating to observe the blood perfusion in the tumor.One nude mouse was executed on the next day in each group,then pathological sections and HE staining of tumor tissue were taken,whereas the growth of the remaining nude mice were observed daily.Results SEM showed the implant with rough and porous surface.The magnetism increased with the volume of material.The tube and bovine liver experiments showed that the PLGA-60 ％ NdFeB-20％ Fe3O4 generated heat efficiently.The bovine liver ablation experiment showed that the range of ablation of 60 μl PLGA-60 ％ NdFeB-20％ Fe3O4 implant reached (2.34±0.25)cm3 after 3 min heating.In vivo experiments showed that the tumor tissue began to form a scab on the 2nd day,and the scab began to desquamate on the 20th day.CEUS showed the original predominant enhancement disappeared significantly after the treatment.HE staining proved that cancer cells had coagulative necrosis,whereas tumors in control group became bigger.Conclusion PLGA-60％ NdFeB-20％ Fe3O4 in situ implant can produce obvious thermal effect under high frequency alternating magnetic field,therefore can be effectively ablated with nude mice MDA-MB-231 breast cancer during time interval heating.

In terms of service management in the medical equipment field, Medical Equipment after-sale Service Satisfaction Evaluation System is established through expert consultation and sample experiment. Meanwhile, questionnaire survey has been applied to local service satisfaction survey work among equipment managements and clinical departments in seventy second and third grade hospitals in Shanghai in ten consecutive years. The result indicates that the satisfaction index has been growing slightly and stably, which clearly demonstrates that the evaluation has continually boosted the service work of various mainstream suppliers. And overall, the evaluation has played an active role in safeguarding and motivating the safety and effectiveness of medical equipment.

Objective To probe the causes of pilot's G-induced loss of consciousness (G-LOC) in air induced by push-pull maneuver (PPM) in human centrifuge training and instruct protective measures of push-pull effect (PPE) for pilots to promote the adaptation of PPE.Methods A pilot experienced air G-LOC induced by PPM participated in the basic tolerance determination and PPE training in human centrifuge.Relaxed + Gz tolerance was determined as qualification with 4.25 G sustained for 10 s.PPE protective training included:① 1 Gz/+4 Gz profile:from + 1.4 Gz baseline declined to-1 Gz with the rate of 1 G/s and sustained for 5 s,then climbed to +4 Gz with 2 G/s onset rate and sustained for 10 s.Pilot's suit pressure was 35 kPa.②-1 Gz/+ 5 Gz profile:from +1.4 Gz baseline declined to-1 Gz with the rate of 1 G/s and sustained for 5 s,and then climbed to +5 Gz with 2 G/s onset rate and sustained for 10 s.Pilot's suit pressure was 45 kPa.Relaxed +Gz tolerance,PPE tolerance of pilots and PPE protective effects were analyzed.Results Pilot's relaxed +Gz tolerance was qualified with the normal electrocardiogram and declined but not flattened ear opacity pulse amplitude.PPM protective measures training:①for-1Gz/+ 4Gz profile:pilot completed standard HP straining maneuver in the training.②for-1 Gz/+5 Gz profile:pilot didn't perform HP maneuver when acceleration transferred from-Gz to +Gz.Finally,he corrected to perform proper HP maneuver under the guidance of instructor and completed the training.Conclusions The improper PPE protective measure leads to the pilot's Gr-LOC in air but not the poor +Gz tolerance.Mechanism and protective measures of PPM and PPE should be preached and PPE protective measures training could be a part of human centrifuge training.

Objective To probe the causes of pilot's G-induced loss of consciousness (G-LOC) in air induced by push-pull maneuver (PPM) in human centrifuge training and instruct protective measures of push-pull effect (PPE) for pilots to promote the adaptation of PPE.Methods A pilot experienced air G-LOC induced by PPM participated in the basic tolerance determination and PPE training in human centrifuge.Relaxed + Gz tolerance was determined as qualification with 4.25 G sustained for 10 s.PPE protective training included:① 1 Gz/+4 Gz profile:from + 1.4 Gz baseline declined to-1 Gz with the rate of 1 G/s and sustained for 5 s,then climbed to +4 Gz with 2 G/s onset rate and sustained for 10 s.Pilot's suit pressure was 35 kPa.②-1 Gz/+ 5 Gz profile:from +1.4 Gz baseline declined to-1 Gz with the rate of 1 G/s and sustained for 5 s,and then climbed to +5 Gz with 2 G/s onset rate and sustained for 10 s.Pilot's suit pressure was 45 kPa.Relaxed +Gz tolerance,PPE tolerance of pilots and PPE protective effects were analyzed.Results Pilot's relaxed +Gz tolerance was qualified with the normal electrocardiogram and declined but not flattened ear opacity pulse amplitude.PPM protective measures training:①for-1Gz/+ 4Gz profile:pilot completed standard HP straining maneuver in the training.②for-1 Gz/+5 Gz profile:pilot didn't perform HP maneuver when acceleration transferred from-Gz to +Gz.Finally,he corrected to perform proper HP maneuver under the guidance of instructor and completed the training.Conclusions The improper PPE protective measure leads to the pilot's Gr-LOC in air but not the poor +Gz tolerance.Mechanism and protective measures of PPM and PPE should be preached and PPE protective measures training could be a part of human centrifuge training.

Taking Endoscopy in hospitals as the research object, study on the safety risk characteristics in digital integration environment. On the basis of risk analysis, risk prevention and control measures are proposed from personnel, equipment, water and electricity, disinfection and the surrounding environment. Establish the endoscope safety risk management safeguard system to improve the safety risk management level of endoscopy.

Through integration of medical imaging resources of 12 community hospitals in the region, a community hospital diagnostic image center was established in 6th hospital. This paper describes the design of the structure and mode of data storage of regional PACS system and the establishment of a database of medical imaging, through which the medical imaging diagnostic level in the community was improved significantly. Through the application of regional PACS system, medical resource was saved and patient treatment facilitated.
Computer Communication Networks ; Information Storage and Retrieval ; methods ; Radiology Information Systems ; Software Design

This article briefly summarized conventional k-space technique, partial k-space sampling and key hole technique, then introduced the latest applications during these years.
Magnetic Resonance Imaging

This paper reviews the basic principles and calculation methods of MR specific absorption rate, discusses the clinical application of MR specific absorption rate.
Humans ; Magnetic Resonance Imaging ; Radio Waves

This article briefly summarized conventional k-space technique, partial k-space sampling and key hole technique, then introduced the latest applications during these years.