Purpose/Significance To propose data governance and fusion technologies for different business application scenarios for the fusion of multi-source and multi-dimensional big data with complex sources and diverse standards.Method/Process Taking the practice of multi-source and multi-dimensional big data fusion in responding to major public health emergencies as an example,the pa-per focuses on the challenges faced by multi-source and multi-dimensional big data fusion,the design of the application architecture,technology integration,the implementation path,the application scenarios,etc.,and analyzes the application effect and the deficiencies that exist.Result/Conclusion Through the design of intelligent multi-source and multi-dimensional big data fusion technology,real-time monitoring,reading,governance,and interactive correlation of high-frequency updates at 100 billion levels are realized,and intel-ligent paths are explored for effectively responding to public emergencies.

Purpose/Significance To design a comprehensive data platform to meet the needs of collecting and sharing survey data on meteorological sensitive diseases,so as to enhance monitoring capabilities for meteorological sensitive diseases in China.Method/Process Through various methods such as data extraction,data exchange,data import and customized collection,disease data,meteoro-logical data,environmental data and diagnosis and treatment data are processed and integrated into the platform for unified management.Result/Conclusion This platform realizes the functions of data collection,aggregation,visualization display and data sharing,which can provide support for scientific researchers in various bases across the country to better manage and utilize meteorological sensitive disease survey data.

Objective To evaluate the application of percutaneous right atrial puncture and tunneled cuffed catheter insertion and the establishment of peripheral arteriovenous(AV)access in hemodialysis patients with superior vena cava occlusion(SVCO),and to provide evidence-based support for the re-establishment of vascular access in patients with limited vascular resources.Methods Patients with SVCO were enrolled.Then,either right neck percutaneous puncture catheterization or peripheral AV access construction was performed on the patients according to their personal preference.The patients were divided into the catheter group and the AV access group accordingly.Under the guidance of double C-arm digital subtraction angiography,a puncture was made in the right brachiocephalic vein or the stump of superior vena cava.Portal venous shunt instrument RUPS100 was then inserted through the guide wire,and the hard end of the guide wire was used to puncture the right atrium to achieve sharp recanalization of the occlusive superior vena cava.Afterwards,balloon expansion of the obstructive superior vena cava lesion and the subsequent implantation of the tunneled-cuffed catheter were performed.In AV access group,after evaluating the collateral veins by venougraphy and the peripheral vessel by ultrasound,autologous AV fistula or graft was established according to the vascular conditions of the patient and their personal preferences.The demographic information and clinical outcomes,such primary and primary assisted patency of access,were documented and the incidence of complications was monitored.With the duration of patent access defined as the survival time,Kaplan-Meier survival analysis was performed to compare the patency rates of the two groups.Results A total of 45 SVCO patients were enrolled and underwent re-establishment of vascular access.Among them,21 cases were in the catheter group and 24 cases were in the AV access group.All patients had their vascular access successfully constructed and received hemodialysis,and no relevant complications or deaths occurred during the procedure.Over the mean follow-up period of(471.22±125.94)days,the primary patency rates in the catheter group 95.2％and 85.7％at 6 and 12 months,respectively,and the primary assisted patency rates were 100％and 95.2％,respectively.The primary patency rates of the AV access group were 79.2％and 62.5％at 6 and 12 months,and the primary assisted patency rates were 95.8％and 87.5％,respectively.No significant difference was observed between the two groups.Kaplan-Meier survival analysis showed that the median survival time(defined as the duration of patent access)was 670.00(468.99,871.01)days in the catheter group and 450.00(339.24,560.76)days in the AV access group,with the catheter group outperforming the AV access group.The primary patency rate of the catheter group was better than that of the AV access group(P=0.049).On the other hand,no significant difference was observed in the primary assisted patency rates of the two groups.Conclusions Long-term vascular access can be established for SVCO patients by either percutaneous catheterization through the right atrium of superior vena cava stump or the establishment of peripheral AV access.The comprehensive plan,which includes the establishment of AV access first and the subsequent catheterization,is expected to improve the total duration of long-term vascular access and prolong the overall survival of dialysis patients,which provides new ideas for re-establishing dialysis access in patients with exhausted central venous resources.

OBJECTIVE To understand the safety of Ilaprazole sodium for injection in clinical practice. METHODS From Jan. 1st 2019 to Feb. 29th 2020， the data of 3 926 valid hospitalized patients receiving Ilaprazole sodium for injection were collected prospectively from 5 third-level hospitals through CHPS， and the post-marketing safety analysis was performed by using retrospective multicenter single cohort study. At the same time， a nested case-control study （the ratio of trial group and control group was 1∶4） was used to confirm the baseline stability of this study cohort and the correlation between adverse reactions and Ilaprazole sodium for injection. RESULTS Among 3 926 patients， 3 patients experienced 5 adverse drug events after using Ilaprazole sodium for injection， with the incidence of 0.076%. There was no serious adverse event， and the occurrence time was 2 days after medication； adverse drug events mainly include elevated liver function indicators （alanine transaminase， aspartate transaminase， total bilirubin）， which were mild and untreated， and all adverse drug events were improved. The results of the nested case-control study showed that the trial group and the control group belonged to the same background baseline， and the occurrence of adverse drug events was more closely related to Ilaprazole sodium for injection. CONCLUSIONS The overall safety of Ilaprazole sodium for injection is relatively high， and the occurrence of adverse events is more related to it.

Objective Tunneled-cuffed catheters(TCCs)are frequently used for establishing hemodialysis access for maintenance hemodialysis in older patients with exhausted resources of peripheral vessels.Fibrin sheath formation around the catheter is one of the most common complications of long-term use of indwelling catheter,which may cause the malfunction of the catheter.In this study,we intend to compare the prognosis of two catheter replacement methods,in situ replacement and replacement through a fibrin sheath crevice,with both being assisted by balloon dilation,and to explore the optimal catheter replacement process.Methods A retrospective study was conducted with 52 patients who underwent a replacement of their TCCs.Among them,27 cases had their TCC replaced by the modified method of replacement through a fibrin sheath crevice and were referred to as the sheath crevice group,while 25 cases underwent in situ catheter replacement and were referred to as the in situ group.The primary outcome indicators included maximum blood flow in hemodialysis catheter and the urea clearance rate calculated by Kt/V values at the 1,3,and 6-month follow-ups.The secondary outcomes included dialyzer alarms being set off and catheter-related infections during follow-up.Results There was no significant difference between the general data of the two groups.There was no massive blood loss during the replacement procedure.Neither were there cardiac tamponade,catheter-associated infections,or other complications.Follow-ups were made 1,3,and 6 months after the replacement procedure.The sheath crevice group had higher catheter blood flow and Kt/V values at the 6-month follow-up than the in situ group did([241.85±9.62]mL/min vs.[234.40±11.21]mL/min,P=0.014 and 1.31±0.55 vs.1.27±0.49,P=0.005,respectively).During the follow-up process,access alarms were reported in 5 patients(three in the in situ group and two in the sheath crevice group)during dialysis.No catheter-associated infection occurred in either group.Conclusion The catheter replacement method of balloon dilation-assisted catheter insertion through a fibrin sheath crevice is safe and effective,resulting in better long-term catheter blood flow compared with that of in situ catheter replacement.

Objective To compare clinical characteristics between acute exacerbated chronic obstructive pulmonary disease (AECOPD) patients with chronic bronchitis phenotype and emphysema phenotype.Methods A total of 73 AECOPD patients with chronic bronchitis phenotype and 82 AECOPD patients with emphysema phenotype in Tibet Chengdu Branch Hospital,West China Hospital,Sichuan University from January 2014 to November 2016 were selected.All patients had completed lung function tests,basic information collection,modified medical research council dyspnea scale (MMRC),and COPD assessment test (CAT).The serum samples were collected to detect C-reactive protein (CRP).The clinical characteristics,lung function,complications and systemic inflammation between the two groups were compared.Results There was no difference in body mass index (BMI),CAT score,serum CRP level and length of hospital stay between the AECOPD patients with chronic bronchitis phenotype and emphysema phenotype (P＞0.05).Compared with AECOPD patients with chronic bronchitis phenotype,the AECOPD patients with emphysema phenotype have longer smoking history,higher MMRC score,and more severe lung function impairment (P＜0.05).Conclusion AECOPD patients with chronic bronchitis phenotype and emphysema phenotype have different clinical characteristics,those with emphysema phenotype have more severe dyspnea and lung function impairment.

The paper comprehensively understands the current construction situation of 30 provincial disease control websites through scientific evaluation methods and professional evaluation indexes,and finds and analyzes the major problems.The result shows that the website construction of disease control system is in the development phase generally,information publication and online service is provided with certain foundation,but the mutual communication and website design are relatively weak links which can be greatly improved.

Objective To explore the role of pregabalin on the expression of c-fos in spinal dorsal horn of the rat with neuropathic pain.Methods Thirty Wister rats (male) were divided into shamoperated group,model group and pregabalin group,with 10 cases in each group.The effect of the pregabalin on the heat pain threshold and expression of c-fos in spinal dorsal horn of the rat with neuropathic pain were observed.Results The heat pain threshold in model group at 3rd,4th,5th,6th,7th,10th and 14th day after operation was significantly lower than that in sham-operated group and pregabalin group at same time (P ＜ 0.05).The heat pain threshold in pregabalin group was lower than that in sham-operated group from 2nd day after operation,but there was no significant difference (P ＞0.05).At the 14th day after operation,the number of Fos-like-immunoreactivity (FLI) positive cells in sham-operated group,model group and pregabalin group was (16.4 ± 0.6),(66.7 ± 3.3) and (22.8 ± 1.5)cases,and the number of FLI positive cells in model group was significantly higher than that in shamoperated group and pregabalin group (P ＜ 0.05).Conclusions Pregabalin has analgesic activity on rat with neuropathic pain.Pregabalin activates spinal cord glial cells raisedby the injured peripheral nerve and infection,and also reduces the noxious stimulation of afferent pain to spinal dorsal horn neurons.