Objective To explore the correlation between amide proton transfer weighted(APTw)imaging of the brain and the clinical psychological scale assessment in patients with Alzheimer's disease(AD).Methods A total of 30 AD patients(AD group)and 33 gender-and age-matched healthy volunteers(control group)were selected and all patients underwent brain MRI,magnetic resonance angiography(MR A)and APTw imaging examinations.According to the APTw images,the magnetization transfer ratio asym-metry(MTRasym)at 3.5 ppm values of each brain region were measured.The differences in MTRasym(3.5 ppm)values of each brain region between the AD group and the control group were compared,and then the diagnostic efficacy of MTRasym(3.5 ppm)values with significant differences were further analyzed.The correlations between the MTRasym(3.5 ppm)values of each brain region and scores of the mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)were analyzed.Results Compared with the control group,the MTRasym(3.5 ppm)values of the left hippocampal head in the AD group were significantly increased(P＜0.05).The area under the curve(AUC)of the receiver operating characteristic(ROC)curve of MTRasym(3.5 ppm)values of the left hippocampal head was 0.656(P＜0.05).MTRasym(3.5 ppm)values of the left hippocampal head,right temporal white matter,and bilateral occipital white matter were significantly negatively correlated with MoCA score(P＜0.05).Conclusion APTw imaging can effectively reflect the changes of protein concentration of the brain regions in AD patients,and is associated with cognitive func-tion,providing a new approach and method for early non-invasive diagnosis and disease monitoring of AD.

Objective To explore the correlation between amide proton transfer weighted(APTw)imaging of the brain and the clinical psychological scale assessment in patients with Alzheimer's disease(AD).Methods A total of 30 AD patients(AD group)and 33 gender-and age-matched healthy volunteers(control group)were selected and all patients underwent brain MRI,magnetic resonance angiography(MR A)and APTw imaging examinations.According to the APTw images,the magnetization transfer ratio asym-metry(MTRasym)at 3.5 ppm values of each brain region were measured.The differences in MTRasym(3.5 ppm)values of each brain region between the AD group and the control group were compared,and then the diagnostic efficacy of MTRasym(3.5 ppm)values with significant differences were further analyzed.The correlations between the MTRasym(3.5 ppm)values of each brain region and scores of the mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)were analyzed.Results Compared with the control group,the MTRasym(3.5 ppm)values of the left hippocampal head in the AD group were significantly increased(P＜0.05).The area under the curve(AUC)of the receiver operating characteristic(ROC)curve of MTRasym(3.5 ppm)values of the left hippocampal head was 0.656(P＜0.05).MTRasym(3.5 ppm)values of the left hippocampal head,right temporal white matter,and bilateral occipital white matter were significantly negatively correlated with MoCA score(P＜0.05).Conclusion APTw imaging can effectively reflect the changes of protein concentration of the brain regions in AD patients,and is associated with cognitive func-tion,providing a new approach and method for early non-invasive diagnosis and disease monitoring of AD.

Objective: Sex differences have been observed in many aspects of schizophrenia, including cognitive deficits. Despite extensive research into the relationship between metabolic factors and cognitive deficits in schizophrenia, few studies have explored the potential sex difference in their association. Methods: We recruited 358 schizophrenia patients and 231 healthy controls. The participants underwent measurements of body mass index (BMI), waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol, and fasting blood glucose. Metabolic risk factors included abdominal obesity, hypertension, hyperglycemia, and dyslipidemia. A collection of these metabolic risk factors has been defined as metabolic syndrome. These diagnoses were based on the criteria of the National Cholesterol Education Program’s Adult Treatment Panel III. Cognitive performance was measured using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). A descriptive analysis, difference analysis, and linear regression model were used to identify the metabolic risk factors for cognitive function in schizophrenia. Results: Our findings revealed sex differences in the rate of abdominal obesity and hypertension in schizophrenic patients. Additionally, we observed sex differences in the association between metabolic risk factors and cognitive impairment in schizophrenia. Specifically, hyperglycemia was associated with the immediate memory index score of RBANS in male patients, while dyslipidemia was associated with language, attention, delayed memory index scores, and RBANS total score in female patients. Conclusion Our results suggest that sex should be considered when evaluating the impact of metabolic disorders on the cognitive function of schizophrenic patients. Moreover, our study identifies hyperglycemia and dyslipidemia as potential targets for precise treatment by sex stratification, which could benefit the improvement of cognitive impairment in schizophrenic patients.

Objective: To investigate the effect of continuous iliac fascia space block on the placement of body position and postoperative analgesia in patients with femoral fractures. Methods: 60 patients with senile selective unilateral femoral fracture, aged 68-87 years old, weight 49-70kg, ASA grade II-III were selected, and they were randomly divided into iliac fascia block group (A group) and intravenous analgesia group (B group) according to the digital, 30 cases in each group.The two groups underwent lumbar epidural anesthesia, A group received continuous fascia iliaca compartment block 15 min before the the body position.B group was routinely given combination of lumbar and hard anesthesia.After operation, A group was connected with the automatic infusion pump continuous infusion of 0.2% ropivacaine 0.1mL·kg^-1·h^-1.B group received controlled intravenous analgesia, postoperative given loading dose of dezocine intravenous infusion of 5mg with automatic injection pump for dezocine 0.01mg·kg^-1·h^-1.When the patients entered the room (T0) and just after the placement of the body position (T1), the heart rate, diastolic blood pressure and systolic blood pressure were measured and recorded.At postoperative 2, 4, 6, 12, 24 and 48h, the VAS scores and pethidine usage during surgery, the adverse reaction were recorded. Results: The heart rate, diastolic pressure and systolic pressure at T1 in A group had no significant change compared with T0 (all P>0.05). The heart rate, diastolic pressure and systolic pressure in the control group (B group) at T1 were significantly higher than at T0(t=5.302, 7.369, 5.629, all P<0.05). At T1, T2, T4, T6, T12, T24 and T48, the pain VAS scores in A group were lower than those in B group (t₁=66.401, t₂=7.719, t₄=25.260, t₆=13.170, t₁₂=3.837, t₂₄=3.081, t₄₈=6.202.all P<0.05). The study group had no complications such as puncture hematoma, intoxication of local anesthetic and other complications. Conclusion Continuous iliofascial block can provide continuous analgesia for elderly patients with femoral fractures.It is safe and effective, and is easy to perform.It provides favorable conditions for later operative treatment.