Objective:To observe the effects of acupuncture on intestinal flora and inflammatory factor interleukin(IL)-6 in ulcerative colitis(UC)model rats and to explore the related mechanism of acupuncture in treating UC.Methods:Thirty-two Sprague-Dawley rats were randomly divided into a normal control(NC)group,a model(MO)group,a mesalazine(ME)group,and an acupuncture(AC)group,with 8 rats in each group.Rats,except those in the NC group,were given a 2.5%sodium dextran sulfate solution to establish UC models.After successful modeling,rats in the ME group were treated with mesalazine by gavage twice a day for 7 continuous days;rats in the AC group received acupuncture at bilateral Tianshu(ST25)and Zusanli(ST36)with needles retained for 20 min each time,once a day for 7 consecutive days.After intervention,changes in the intestinal flora diversity,colon tissue damage degree,and inflammatory factor expression in each group of rats were evaluated.Results:The body mass increased slowly in the MO group compared to the NC group.After intervention,the body mass increased more significantly,colon injuries recovered,and intestinal flora diversity improved in the ME and AC groups compared to the MO group(P<0.05).The IL-6 expression level was higher in the MO group compared to the NC group(P<0.05).The IL-6 expression level decreased in the AC group compared to the MO group(P<0.05).Conclusion:Acupuncture at Tianshu(ST25)and Zusanli(ST36)improves body mass loss and colon injuries,regulates intestinal flora diversity,and reduces the expression of inflammatory factor IL-6 in the colon tissue of UC rats,therefore alleviating the disease severity of UC.

Objective:To observe the effects of acupuncture on intestinal flora and inflammatory factor interleukin(IL)-6 in ulcerative colitis(UC)model rats and to explore the related mechanism of acupuncture in treating UC.Methods:Thirty-two Sprague-Dawley rats were randomly divided into a normal control(NC)group,a model(MO)group,a mesalazine(ME)group,and an acupuncture(AC)group,with 8 rats in each group.Rats,except those in the NC group,were given a 2.5%sodium dextran sulfate solution to establish UC models.After successful modeling,rats in the ME group were treated with mesalazine by gavage twice a day for 7 continuous days;rats in the AC group received acupuncture at bilateral Tianshu(ST25)and Zusanli(ST36)with needles retained for 20 min each time,once a day for 7 consecutive days.After intervention,changes in the intestinal flora diversity,colon tissue damage degree,and inflammatory factor expression in each group of rats were evaluated.Results:The body mass increased slowly in the MO group compared to the NC group.After intervention,the body mass increased more significantly,colon injuries recovered,and intestinal flora diversity improved in the ME and AC groups compared to the MO group(P<0.05).The IL-6 expression level was higher in the MO group compared to the NC group(P<0.05).The IL-6 expression level decreased in the AC group compared to the MO group(P<0.05).Conclusion:Acupuncture at Tianshu(ST25)and Zusanli(ST36)improves body mass loss and colon injuries,regulates intestinal flora diversity,and reduces the expression of inflammatory factor IL-6 in the colon tissue of UC rats,therefore alleviating the disease severity of UC.

Objective? To investigate the effectiveness of family-based telenursing on the management of pressure sores in discharged emergency patients with pressure sores. Methods? Using the convenient sampling method, we selected 100 dyads of pressure sores patients along with their main home caregiver (one caregiver per patient). The patients were admitted to the Emergency Department of Beijing Anzhen Hospital from January to December 2017, who were randomly divided into the observation group and control group (50 dyads for each group). After the discharge of the control group, routine follow-ups were administered to guide the care of pressure sores. After the discharge of the observation group, the family-based telenursing was implemented for pressure sore management. The differences between the two groups of patients at the time of discharge, 2 months after discharge, nursing knowledge of pressure sore disease, differences in home care ability, and satisfaction with pressure sores management were analyzed. Results? There were no significant differences between the two groups at the time of discharge (P＞ 0.05). After 2 months of discharge, the severity of pressure sores, risk score, and recurrence rate of pressure sores in the observation group were lower than those in the control group, and the differences were statistically significant (P＜ 0.05). The caregiver's knowledge of pressure sores in the observation group was better than the control group, and the difference was statistically significant (P＜0.05). The total scores and the dimension scores of the family nursing evaluation in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Patients and caregivers in the observation group were more satisfied with the nursing methods than the control group (P＜0.05). Conclusions? Family-based telenursing can improve the knowledge of pressure sores, the nursing ability,and effectively manage pressure sores.