Objective To evaluate the levels of serum 25 hydroxyvitamin D (25(OH)D), parathyroid hormone(PTH)and osteocalcin,as well as bone mineral density(BMD),in aged men in Beijing, and the relationship among these factors.Methods A total of 668 elderly male patients who were treated at the Beijing Friendship Hospital were evaluated, and their medical data were collected. The serum concentrations of 25(OH)D,PTH,and osteocalcin were measured.Additionally,bone mineral density at the lumbar spine1- 4(L1- 4) and left femoral neck were measured using dual-energy X-ray absorptiometry. Participants were divided into 4 groups by age,3 groups according to BMD,and 4 groups according to serum 25(OH)D levels. The relationship among these factors was investigated. Results The mean serum concentrations of 25(OH)D and PTH were (40.2 ± 17.3) nmol/L and (45.19 ± 15.54) ng/L, respectively. The serum 25(OH)D levels in the group aged≥90 years[(27.1±16.8)nmol/L]was significantly lower compared to that in the other groups. Among different BMD groups, serum 25(OH)D levels reduced gradually, but differences were not significant(P>0.05).Age and PTH levels were not significantly associated with 25(OH) D groups (P>0.05). However, BMD of the femoral neck in the groups with severe [(0.782±0.121)g/m2] and mild[(0.775±0.247)g/m2]vitamin D deficiency were significantly lower than that in the group with normal vitamin D levels [(0.837 ± 0.192) g/m2] (P<0.05). With the increase in vitamin D levels, osteocalcin levels decreased significantly(P<0.05).Conclusion Vitamin D deficiency is highly prevalent among aged men in Beijing and the 25(OH)D levels have some correlation with BMD and osteocalcin.

Objective To investigate the association between warfarin drug effects and vitamin K epoxide reductase complex subunit 1 (VKORC1)-1639 G/A gene polymorphisms in Han Chinese very elderly patients.Methods The subjects were elderly patients aged more than 60 years, with stable anticoagulation with warfarin and the target international normalized ratio(INR), who were hospitalized in Beijing Friendship Hospital, Capital Medical University from August 2009 to August 2016.The patients were divided into the very elderly group and aged group.The first record of warfarin dosage, the duration of achieving stable dosage (defined as the initial stage of treatment) and warfarin stable dosage were recorded.The bleeding and embolism events during early treatment were observed.After INR was at the steady state, genotyping for the VKORC1-1639 G/A alleles were tested.The effects of drugs and complications in warfarin initiation therapy were also investigated.Results A total of 322 patients were enrolled, including 300 cases of atrial fibrillation and 22 cases of pulmonary embolism.The very elderly group had 200 cases, including 110 males and 90 females;their ages ranged from 75 to 96 years, the average age was (83+7).The aged group had 122 cases, including 68 males, 54 females, their ages ranged from 60 to less than 75 years, the average age was (67±8).The VKORC1-1639 G/A genotype included 256 cases of AA type (79.5%) which contained 150 males and 106 females, and 62 cases of type AG (19.3%) which contained 26 males and 36 females.The GG type included 4 cases (1.2%), containing 2 males and 2 females.Genotype distribution accorded with the law of genetic equilibrium.There was no significant difference in VKORC1-1639 G/A genotype distribution between the aged group and the very elderly group (P>0.05).The carriers of VKORC1-1639 AG+GG genotype had a significantly higher warfarin stable dosage than those of AA genotype [(2.90±1.39)mg vs.(2.00±1.14)mg, t=5.39, P<0.01].In the same genotype, the very elderly patients had a decreased warfarin stable dosage compared with the aged patients [AA: (1.62±1.24)mg vs.(2.58±0.98)mg, t=6.68, P<0.01;AG+GG: (2.43±0.55)mg vs.(3.36±1.52)mg, t=3.97, P<0.01].The AG+GG patients have a longer time to achieve stable dosage-effect relation compared with AA genotype [(18.9±2.8)d vs.(11.2±2.5)d, t=4.28, P=0.01].Conclusions Warfarin stable dosage was related to patient age and VKORC1-1639 gene polymorphism.According to the results of VKORC1-1639 genotype testing to adjust warfarin dose maybe have some clinical significance in Han elderly patients.

Objective To investigate the association between warfarin drug effects and vitamin K epoxide reductase complex subunit 1 (VKORC1)-1639 G/A gene polymorphisms in Han Chinese very elderly patients.Methods The subjects were elderly patients aged more than 60 years, with stable anticoagulation with warfarin and the target international normalized ratio(INR), who were hospitalized in Beijing Friendship Hospital, Capital Medical University from August 2009 to August 2016.The patients were divided into the very elderly group and aged group.The first record of warfarin dosage, the duration of achieving stable dosage (defined as the initial stage of treatment) and warfarin stable dosage were recorded.The bleeding and embolism events during early treatment were observed.After INR was at the steady state, genotyping for the VKORC1-1639 G/A alleles were tested.The effects of drugs and complications in warfarin initiation therapy were also investigated.Results A total of 322 patients were enrolled, including 300 cases of atrial fibrillation and 22 cases of pulmonary embolism.The very elderly group had 200 cases, including 110 males and 90 females;their ages ranged from 75 to 96 years, the average age was (83+7).The aged group had 122 cases, including 68 males, 54 females, their ages ranged from 60 to less than 75 years, the average age was (67±8).The VKORC1-1639 G/A genotype included 256 cases of AA type (79.5%) which contained 150 males and 106 females, and 62 cases of type AG (19.3%) which contained 26 males and 36 females.The GG type included 4 cases (1.2%), containing 2 males and 2 females.Genotype distribution accorded with the law of genetic equilibrium.There was no significant difference in VKORC1-1639 G/A genotype distribution between the aged group and the very elderly group (P>0.05).The carriers of VKORC1-1639 AG+GG genotype had a significantly higher warfarin stable dosage than those of AA genotype [(2.90±1.39)mg vs.(2.00±1.14)mg, t=5.39, P<0.01].In the same genotype, the very elderly patients had a decreased warfarin stable dosage compared with the aged patients [AA: (1.62±1.24)mg vs.(2.58±0.98)mg, t=6.68, P<0.01;AG+GG: (2.43±0.55)mg vs.(3.36±1.52)mg, t=3.97, P<0.01].The AG+GG patients have a longer time to achieve stable dosage-effect relation compared with AA genotype [(18.9±2.8)d vs.(11.2±2.5)d, t=4.28, P=0.01].Conclusions Warfarin stable dosage was related to patient age and VKORC1-1639 gene polymorphism.According to the results of VKORC1-1639 genotype testing to adjust warfarin dose maybe have some clinical significance in Han elderly patients.

Objective To analyze the clinical characteristics of large pulmonary vessel involvement in Behcet's diseaseMethods The clinical data of Behcet's disease patients with large pulmonary vessel involvement,who were treated in Peking Union Medical College Hospital from 1983 to 2008,were retrospectively analyzed.Results Thirteen patients had large pulmonary vessel involvement among a total of 418 patients with Behcet's disease.The 13 patients had a mean age of (37.5?12)years old,with 10(69.2%)having hemoptysis,8(61.5%)having dyspnea.Helical CT/CTPA showed that pulmonary vascular involvement included pulmonary arterial aneurysms(53.8%),pulmonary artery occlusion(46.2%),and pulmonary thrombi(46.2%).All the 13 patients were treated with steroid and immunosuppressant;five received steroid pulse therapy;and four received vascular intervention therapy.The mean follow-up was (3?1.6)years,with a follow-up rate of 92.5%.The 3-year survival rate was 83.9% for the 13 patients.Conclusion The manifestation of pulmonary vascular involvement in Behcet's disease is various,and the diagnosis mainly depends on the manifestations of CT pulmonary angiography.