Nuclear radiation exposure events and tumor radiotherapy are highly susceptible to a range of psychological, physiological and other health problems, which can seriously affect patients' quality of life. It has been shown that 87.5 % of tumor patients are exposed to varying degrees of radiation injury during radiotherapy. The treatment of radiation injury (RI) in modern medicine is limited to drug therapy, cell therapy, etc. Among them, the most chemical drugs cause many adverse reactions including fatigue, nausea, vomiting, etc., and there are very few drugs dedicated to the treatment of RI. Traditional Chinese medicine (TCM) is a rich natural medicinal resource, which has a wide range of pharmacological activities, multiple targets of action and minimal toxic side effects. Many studies have demonstrated that TCM and its compound preparations have enormous potential in the treatment of radiation induced comprehensive diseases. However, TCM is limited in clinical application due to its slow onset of action, complex active ingredients, and low bioavailability. Therefore, the article reviews the application, molecular mechanisms, and new dosage forms of TCM in the prevention and treatment of RI. On this basis, we will focus on discussing the development advantages and application prospects of the combination of traditional Chinese and Western medicine to achieve highly efficient treatment of RI. This review aims to provide scientific and effective drug delivery strategies and basic theoretical support for the clinical effective treatment of RI with TCM, and further promote the innovative development of TCM.

ObjectiveTo understand the surveillance of influenza-like illness (ILI) and influenza vaccination status in Jing’an District, Shanghai, and to provide a basis for optimizing influenza prevention and control strategies. MethodsThe sentinel surveillance data for ILI and virological surveillance data of influenza viruses in Jing’an District were collected from the Chinese influenza surveillance information system, and data for influenza vaccination were collected from Shanghai immunization information system from September 2017 to August 2023. Epidemiological characteristics of ILI, influenza etiology, and the temporal and population distributions of influenza vaccination were analyzed using descriptive epidemiological methods. ResultsILI as a percentage of total visit surveillance units (ILI%) reported by sentinel hospital was increased in Jing’an District of Shanghai from September 2017 to August 2023 (F=18.841, P=0.012). The peak of the influenza cases mainly appeared in winter-spring, but there were two peaks in winter-spring and summer from September 2019 to August 2020, from September 2020 to August 2021, and from September 2021 to August 2022. In particular, there were two peaks in winter-spring from September 2022 to August 2023, with a rebound during the descending process. The average positive rate of ILI was 21.64% (2 421/11 189) during the 6 years. There was a peak in winter-spring during every year with the exception of the period from September 2020 to August 2021. The dominant strains were B/Yamagata and A/H1N1 in winter-spring from September 2017 to August 2018. The dominant strain was A/H1N1 in winter-spring from September 2018 to August 2019 and from September 2022 to August 2023. The dominant strain was B/Victoria in winter-spring from September 2019 to August 2020 and from September 2021 to August 2022. Different subtype strains occurred alternately, and the dominant strains were A/H1N1 and A/H3N2 in recent years. The influenza vaccination coverage was 2.94% from September 2017 to August 2023, and the vaccination coverage was highest in young children. The vaccination coverage for females was higher than that for males (χ²=546.963, P<0.001), and the vaccination coverage for registered residents was higher compared to that for migrants (χ²=123.141, P<0.001). ConclusionILI% exhibits an upward trend in Jing’an District of Shanghai, and the dominant strain is A subtype. The influenza vaccination coverage is still low, which is insufficient to have an impact on the spread of influenza. It is recommended that the surveillance of ILI and variations of influenza virus strains should be improved continuously, and effective steps should be taken to promote influenza vaccination.

Objective:To summarize the clinical characteristics of SAPHO syndrome in elderly patients with organizing pneumonia.Methods:We reported a case of SAPHO syndrome in an elderly patient with organizing pneumonia.Relevant reports on SAPHO syndrome with organizing pneumonia at home and abroad were retrieved, and the literature was summarized an analyzed.Results:The patient was a 63-year-od female who was admitted to the hospital due to "intermittent fever and cough for more than two months". Before admission, she was previously diagnosed with pneumonia in another hospital with poor response to anti-infective treatment.Chest CT showed multiple bilateral patchy consolidations in both lungs, with migratory changes and reversed halo signs.Her medical history included bone and joint pain(e.g., sternoclavicular joints)and palmoplantar pustulosis.Lung biopsy pathology confirmed organizing pneumonia. 99mTc-MDP bone scintigraphy revealed abnormal bone salt metabolism in multiple bone and joint areas.The final diagnosis was SAPHO syndrome with organizing pneumonia.Both symptoms and imaging significantly improved after prednisone treatment.Two related cases were retrieved from the literature.One was a 57-year-old female reported in the UK, who had been diagnosed with SAPHO syndrome before and was found to have lung consolidations due to respiratory symptoms.Lung biopsy confirmed organizing pneumonia, and she improved after glucocorticoid treatment.The other was a 59-year-old Chinese female who visited hospital due to pain in the lumbosacral part and left lower limb.After being diagnosed with SAPHO syndrome, a chest CT scan was performed and lung consolidations were found.The pathology confirmed organizing pneumonia.The patient improved after treatment with Tripterygium wilfordii. Conclusion:SAPHO syndrome complicated with organizing pneumonia is rare, with diverse clinical manifestations, and responds well to glucocorticoid therapy.

Objective:To investigate brain damage and treatment efficacy in patients with first-episode schizophrenia with comorbid auditory and visual hallucinations and cognitive decline based on brain magnetic resonance imaging (MRI).Methods:This study adopted a retrospective cohort design. Eighty patients with first-episode schizophrenia who received treatment at Wenzhou Seventh People's Hospital from January to June 2024 were included in this study. The patients were divided into an observation group (40 cases of first-episode schizophrenia with comorbid auditory and visual hallucinations) and a control group (40 cases of first-episode schizophrenia without comorbid auditory and visual hallucinations) based on whether they had symptoms of comorbid auditory and visual hallucinations. Forty healthy individuals who concurrently underwent physical examinations were included in the normal group. All patients received standardized treatment. Cranial MRI data were collected from all subjects. Cranial MRI data, Positive and Negative Syndrome Scale (PANSS) score, Global Assessment of Functioning (GAF) score, and changes in cognitive function were compared among the three groups. Additionally, the changes in cranial MRI data, PANSS score, GAF score, and the score of MATRICS Consensus Cognitive Battery (MCCB) in the observation group were compared between before and after treatment.Results:The horizontal distance between the corpus callosum and the underside of the cingulate gyrus, the vertical distance between the corpus callosum and the underside of the cingulate gyrus, and PANSS and GAF scores in the observation group were all significantly higher than those in the normal and control groups (all P < 0.05). The scores on all MCCB scales in the observation group were significantly lower than those in the normal and control groups (all P < 0.05). After treatment, the left horizontal distance between the corpus callosum and the underside of the cingulate gyrus [(5.72 ± 0.71) mm] and the right horizontal distance [(5.13 ± 0.55) mm], as well as the left vertical distance [(6.37 ± 0.69) mm] and the right vertical distance [(5.61 ± 0.67) mm], were all significantly lower than the pre-treatment values [(6.98 ± 0.83) mm, (6.07 ± 0.49) mm, (7.54 ± 0.58) mm, and (6.52 ± 0.51) mm, t = 7.30, 8.07, 8.21, 6.84, all P < 0.05]. Post-treatment PANSS scores [(39.95 ± 6.65)] were significantly lower than pre-treatment scores [(97.47 ± 18.47)], while post-treatment GAF scores [(71.26 ± 8.87)] were significantly higher than pre-treatment scores [(34.68 ± 7.71), t = 18.53, 19.69, both P < 0.05]. Post-treatment scores for the MCCB [(8.57 ± 2.45), (2.25 ± 0.47), (25.16 ± 2.43), (24.10 ± 2.64), (17.08 ± 2.25), (20.43 ± 3.76), (2.07 ± 0.36), (22.16 ± 3.24), (57.81 ± 7.69), (0.28 ± 0.05)] were significantly higher than pre-treatment scores [(5.65 ± 1.37), (1.62 ± 0.34), (21.21 ± 2.27), (20.27 ± 1.78), (12.16 ± 2.08), (14.56 ± 2.34), (1.71 ± 0.25), (17.92 ± 1.64), (40.29 ± 6.56), (0.21 ± 0.03), t = 6.58, 6.87, 7.51, 7.61, 10.15, 8.38, 5.19, 7.38, 10.96, 7.59, all P < 0.05]. Conclusions:The comorbid auditory and visual hallucinations in patients with first-episode schizophrenia, based on brain MRI findings, are closely related to cognitive decline and brain damage. After treatment, both cognitive function and cranial damage in these patients have considerably improved, which is worthy of clinical consideration.

Objective:To investigate brain damage and treatment efficacy in patients with first-episode schizophrenia with comorbid auditory and visual hallucinations and cognitive decline based on brain magnetic resonance imaging (MRI).Methods:This study adopted a retrospective cohort design. Eighty patients with first-episode schizophrenia who received treatment at Wenzhou Seventh People's Hospital from January to June 2024 were included in this study. The patients were divided into an observation group (40 cases of first-episode schizophrenia with comorbid auditory and visual hallucinations) and a control group (40 cases of first-episode schizophrenia without comorbid auditory and visual hallucinations) based on whether they had symptoms of comorbid auditory and visual hallucinations. Forty healthy individuals who concurrently underwent physical examinations were included in the normal group. All patients received standardized treatment. Cranial MRI data were collected from all subjects. Cranial MRI data, Positive and Negative Syndrome Scale (PANSS) score, Global Assessment of Functioning (GAF) score, and changes in cognitive function were compared among the three groups. Additionally, the changes in cranial MRI data, PANSS score, GAF score, and the score of MATRICS Consensus Cognitive Battery (MCCB) in the observation group were compared between before and after treatment.Results:The horizontal distance between the corpus callosum and the underside of the cingulate gyrus, the vertical distance between the corpus callosum and the underside of the cingulate gyrus, and PANSS and GAF scores in the observation group were all significantly higher than those in the normal and control groups (all P < 0.05). The scores on all MCCB scales in the observation group were significantly lower than those in the normal and control groups (all P < 0.05). After treatment, the left horizontal distance between the corpus callosum and the underside of the cingulate gyrus [(5.72 ± 0.71) mm] and the right horizontal distance [(5.13 ± 0.55) mm], as well as the left vertical distance [(6.37 ± 0.69) mm] and the right vertical distance [(5.61 ± 0.67) mm], were all significantly lower than the pre-treatment values [(6.98 ± 0.83) mm, (6.07 ± 0.49) mm, (7.54 ± 0.58) mm, and (6.52 ± 0.51) mm, t = 7.30, 8.07, 8.21, 6.84, all P < 0.05]. Post-treatment PANSS scores [(39.95 ± 6.65)] were significantly lower than pre-treatment scores [(97.47 ± 18.47)], while post-treatment GAF scores [(71.26 ± 8.87)] were significantly higher than pre-treatment scores [(34.68 ± 7.71), t = 18.53, 19.69, both P < 0.05]. Post-treatment scores for the MCCB [(8.57 ± 2.45), (2.25 ± 0.47), (25.16 ± 2.43), (24.10 ± 2.64), (17.08 ± 2.25), (20.43 ± 3.76), (2.07 ± 0.36), (22.16 ± 3.24), (57.81 ± 7.69), (0.28 ± 0.05)] were significantly higher than pre-treatment scores [(5.65 ± 1.37), (1.62 ± 0.34), (21.21 ± 2.27), (20.27 ± 1.78), (12.16 ± 2.08), (14.56 ± 2.34), (1.71 ± 0.25), (17.92 ± 1.64), (40.29 ± 6.56), (0.21 ± 0.03), t = 6.58, 6.87, 7.51, 7.61, 10.15, 8.38, 5.19, 7.38, 10.96, 7.59, all P < 0.05]. Conclusions:The comorbid auditory and visual hallucinations in patients with first-episode schizophrenia, based on brain MRI findings, are closely related to cognitive decline and brain damage. After treatment, both cognitive function and cranial damage in these patients have considerably improved, which is worthy of clinical consideration.

Objective:To summarize the clinical characteristics of SAPHO syndrome in elderly patients with organizing pneumonia.Methods:We reported a case of SAPHO syndrome in an elderly patient with organizing pneumonia.Relevant reports on SAPHO syndrome with organizing pneumonia at home and abroad were retrieved, and the literature was summarized an analyzed.Results:The patient was a 63-year-od female who was admitted to the hospital due to "intermittent fever and cough for more than two months". Before admission, she was previously diagnosed with pneumonia in another hospital with poor response to anti-infective treatment.Chest CT showed multiple bilateral patchy consolidations in both lungs, with migratory changes and reversed halo signs.Her medical history included bone and joint pain(e.g., sternoclavicular joints)and palmoplantar pustulosis.Lung biopsy pathology confirmed organizing pneumonia. 99mTc-MDP bone scintigraphy revealed abnormal bone salt metabolism in multiple bone and joint areas.The final diagnosis was SAPHO syndrome with organizing pneumonia.Both symptoms and imaging significantly improved after prednisone treatment.Two related cases were retrieved from the literature.One was a 57-year-old female reported in the UK, who had been diagnosed with SAPHO syndrome before and was found to have lung consolidations due to respiratory symptoms.Lung biopsy confirmed organizing pneumonia, and she improved after glucocorticoid treatment.The other was a 59-year-old Chinese female who visited hospital due to pain in the lumbosacral part and left lower limb.After being diagnosed with SAPHO syndrome, a chest CT scan was performed and lung consolidations were found.The pathology confirmed organizing pneumonia.The patient improved after treatment with Tripterygium wilfordii. Conclusion:SAPHO syndrome complicated with organizing pneumonia is rare, with diverse clinical manifestations, and responds well to glucocorticoid therapy.

Objective To explore the prognostic value of neuroimaging score in patients with acute vertebrobasilar artery occlusion(VBAO)with successful revascularization.Methods A total of 83 patients with acute VBAO who underwent endovascular treatment with successful recanalization,modified thrombolysis for cerebral infarction grade 2b or 3 were retrospectively selected.Based on baseline diffusion weighted imaging(DWI)sequences,posterior circulation infarcts were assessed using the novel posterior circulation score(N-PCS),brainstem score(BSS),and posterior circulation Alberta stroke program early CT score(pc-ASPECTS).A 90 d modified Rankin scale(mRS)score ≤2 points was defined as functional independence.The predictive value of the three scores was assessed by the receiver operating characteristic(ROC)curve analysis.Results The N-PCS[median(interquartile range):2(1-2)vs 4(2-5)]was statistically significant between the functional independent group(50 cases)and the poor group(33 cases)(P＜0.001).Multifactorial logistic regression analysis showed that age[adjusted odds ratio(OR)1.08;95％confidence interval(CI)1.02-1.14;P=0.006],baseline National Institutes of Health Stroke Scale(NIHSS)(adjusted OR 1.12;95％CI 1.03-1.20;P=0.005),and N-PCS(adjusted OR 2.84;95％CI 1.30-6.19;P=0.009)were independent prognostic factors for a favorable prognosis.Conclusion The N-PCS based on DWI can predict the prognosis of acute VBAO patients with successful revascularization.

Objective:To analyze the impact of serum anti-Müllerian hormone (AMH) on the rate and number of euploid blastocysts among women undergoing intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidies (PGT-A).Methods:A retrospective cohort study was performed by analyzing clinical data from 504 patients approaching ICSI cycle with PGT-A in Reproductive Medicine Center of Peking University Third Hospital from January 1st 2018 to December 31st 2020. According to serum AMH level measured before ovarian stimulation, subjects were divided into two groups: the low AMH group (AMH<1.00 μg/L, 85 patients) and the normal AMH group (AMH≥1.00 μg/L, 419 patients). Rates and number of euploid blastocysts were compared between the two groups (82 patients per group) after using propensity score matching (PSM) to adjust confounding variables, including age, body mass index (BMI), history of recurrent miscarriage and ovarian stimulation protocols.Results:1) The rate and number of euploid blastocysts were significantly lower in the low AMH group [50.0% (0, 100.0%), 1 (0, 1)] than in the normal AMH group [60.0% (33.3%, 100.0%), P=0.025; 1 (1, 2), P<0.001]. 2) After PSM, the rate of euploid blastocysts was 50.0% (0, 100.0%) in the low AMH group and 50.0% (19.2%, 100.0%) in the normal AMH group, with no significant difference ( P=0.265). Patients in the low AMH group had significantly fewer euploid blastocysts [1 (0, 1) vs. 1 (1, 2), P=0.004] and were less likely to have at least one euploid blastocyst [57.3% (47/82) vs. 76.8% (63/82), P=0.008]. 3) A total of 378 (75.0%) cycles had at least one euploid embryo. The area under the curve (AUC) value of AMH combined with age in predicting the presence of at least one euploid embryo was better than that of age alone (0.78 vs. 0.75, P=0.024). Conclusion:Serum AMH level is not independently associated with the rate of blastocyst euploidy after adjusting for age, BMI, history of recurrent abortion and ovulation induction protocol. AMH combined with age can be used to predict the possibility of having at least one euploid embryo per cycle.

Objective:To compare the clinical outcome of whole frozen-thawed embryo transfer in patients with high ovarian response using gonadotropin-releasing hormone agonist (GnRH-a) single trigger or combined with low-dose human chorionic gonadotropin (hCG) dual trigger in the gonadotropin-releasing hormone antagonist (GnRH-A) protocol.Methods:Retrospective cohort study was conducted in Center for Reproductive Medicine, Department of Obstetrics and Gynecology of Peking University Third Hospital between January 2018 to December 2020, and the patients with high ovarian response undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) were divided into GnRH-a single trigger group (group A, n=251) and GnRH-a combined with low-dose hCG dual trigger group (group B, n=741) according to the trigger protocol. The clinical outcome was compared between the two groups. Results:There were no significant differences in clinical characteristics between group A and group B. Estrogen level on the day of trigger, number of embryos formed, number of two pronuclei (2PN) embryos formed, number of high-quality embryos formed and rate of embryo formation in group A were significantly higher than those in group B [(22 905.84±9 513.28) pmol/L vs. (17 200.82±6 811.64) pmol/L, P<0.001; 18.84±9.50 vs. 17.34±8.04, P=0.025; 16.06±8.24 vs. 14.87±7.07, P=0.042; 11.25±6.92 vs. 10.25±5.97, P=0.027; 68.6% (4 730/6 899) vs. 66.5% (12 852/19 326), P=0.002]. However, there were no significant differences in number of oocytes retrieved, mature oocyte rate and high-quality embryo rate between group A and group B (all P>0.05). There were also no significant differences in hCG positive rate, clinical pregnancy rate, abortion rate, ectopic pregnancy rate, persistent pregnancy rate and live birth rate per frozen-thawed embryo transfer between the two groups (all P>0.05). There were no significant differences in cumulative persistent pregnancy rate, cumulative live birth rate, proportion of low birth weight infants and birth defects per ovarian stimulation cycle between the two groups (all P>0.05). The incidence of early-onset severe ovarian hyperstimulation syndrome (OHSS) in group A was lower than that in group B, but there was no significant difference [0% vs. 1.5% (11/741), P=0.075]. Conclusion:The pregnancy outcome of whole frozen-thawed embryo transfer in patients with high ovarian response using GnRH-a single trigger was comparable to dual trigger combined with low-dose hCG in the GnRH-A protocol, and the risk of early onset severe OHSS was low. Therefore, in patients with high ovarian response in IVF/ICSI cycle using GnRH-A protocol, the use of GnRH-a single trigger followed by whole frozen-thawed embryo transfer could be considered as an optimal choice to minimize the risk of early onset OHSS without loss of pregnancy outcome.

Objective:To analyze the impact of serum anti-Müllerian hormone (AMH) on the rate and number of euploid blastocysts among women undergoing intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidies (PGT-A).Methods:A retrospective cohort study was performed by analyzing clinical data from 504 patients approaching ICSI cycle with PGT-A in Reproductive Medicine Center of Peking University Third Hospital from January 1st 2018 to December 31st 2020. According to serum AMH level measured before ovarian stimulation, subjects were divided into two groups: the low AMH group (AMH<1.00 μg/L, 85 patients) and the normal AMH group (AMH≥1.00 μg/L, 419 patients). Rates and number of euploid blastocysts were compared between the two groups (82 patients per group) after using propensity score matching (PSM) to adjust confounding variables, including age, body mass index (BMI), history of recurrent miscarriage and ovarian stimulation protocols.Results:1) The rate and number of euploid blastocysts were significantly lower in the low AMH group [50.0% (0, 100.0%), 1 (0, 1)] than in the normal AMH group [60.0% (33.3%, 100.0%), P=0.025; 1 (1, 2), P<0.001]. 2) After PSM, the rate of euploid blastocysts was 50.0% (0, 100.0%) in the low AMH group and 50.0% (19.2%, 100.0%) in the normal AMH group, with no significant difference ( P=0.265). Patients in the low AMH group had significantly fewer euploid blastocysts [1 (0, 1) vs. 1 (1, 2), P=0.004] and were less likely to have at least one euploid blastocyst [57.3% (47/82) vs. 76.8% (63/82), P=0.008]. 3) A total of 378 (75.0%) cycles had at least one euploid embryo. The area under the curve (AUC) value of AMH combined with age in predicting the presence of at least one euploid embryo was better than that of age alone (0.78 vs. 0.75, P=0.024). Conclusion:Serum AMH level is not independently associated with the rate of blastocyst euploidy after adjusting for age, BMI, history of recurrent abortion and ovulation induction protocol. AMH combined with age can be used to predict the possibility of having at least one euploid embryo per cycle.