Objective To explore the predictive value of neutrophil to platelet ratio(NPR)in acute renal injury(AKI)in sepsis.Methods Patients with sepsis admitted to the emergency intensive care unit of Xinjiang Uygur Autonomous Region People's Hospital from February 2023 to May 2024 were retrospectively analyzed.According to the guidelines of the Global Organization for Improving the Progno-sis of Nephropathy(KDIGO)in 2012,septic patients were divided into acute renal injury group(AKI group)and non-acute renal injury group(non-AKI group).The basic clinical data on admission,including age,complications,28-day prognosis and the first neutrophil count,platelet count,procalcitonin,lactic acid and NPR within 24hours after admission were recorded and compared between the two groups.The risk factors of septic AKI were screened by Logistic regression analysis,the diagnostic efficacy of NPR in septic AKI was eval-uated by receiver operating characteristic(ROC)curve,and the correlation between NPR and AKI stage of sepsis was analyzed by Spearman.Results Finally,159 patients with sepsis were included,including 87 patients in AKI group and 72 patients in non-AKI group.The incidence of AKI was 54.7％.Compared with non-AKI group,procalcitonin,IL-6,lactic acid,D-dimer,uric acid,NPR,neutrophil to lymphocyte ratio(NLR),neutrophil to lymphocyte and platelet ratio(N/LPR)in septic AKI group were significantly higher than those in septic non-AKI group,while the platelet count and lymphocyte count in sepsis group were significantly lower than those in non-AKI group(P＜0.05).Multivariate Logistic regression analysis showed that the increase of NPR,lactic acid,uric acid and the decrease of lymphocyte count were the independent risk factors of septic AKI.ROC curve analysis showed that NPR had good clinical value in predicting the occurrence of septic AKI.The area under the curve(AUC)was 0.731,which was better than that of NLR,but lower than N/LPR,and the predictive efficacy of N/LPR was also higher than that of the combination of NPR and NLR.Spearman corre-lation analysis showed that there was a positive correlation between NPR,N/LPR and AKI stage in patients with sepsis AKI.Conclusion The increase of admission NPR is an independent risk factor for septic AKI,which has a good predictive value,and high NPR is more closely related to the risk of severe AKI in septic AKI patients.NPR can predict the occurrence of septic AKI to some extent.

Objective To explore the predictive value of neutrophil to platelet ratio(NPR)in acute renal injury(AKI)in sepsis.Methods Patients with sepsis admitted to the emergency intensive care unit of Xinjiang Uygur Autonomous Region People's Hospital from February 2023 to May 2024 were retrospectively analyzed.According to the guidelines of the Global Organization for Improving the Progno-sis of Nephropathy(KDIGO)in 2012,septic patients were divided into acute renal injury group(AKI group)and non-acute renal injury group(non-AKI group).The basic clinical data on admission,including age,complications,28-day prognosis and the first neutrophil count,platelet count,procalcitonin,lactic acid and NPR within 24hours after admission were recorded and compared between the two groups.The risk factors of septic AKI were screened by Logistic regression analysis,the diagnostic efficacy of NPR in septic AKI was eval-uated by receiver operating characteristic(ROC)curve,and the correlation between NPR and AKI stage of sepsis was analyzed by Spearman.Results Finally,159 patients with sepsis were included,including 87 patients in AKI group and 72 patients in non-AKI group.The incidence of AKI was 54.7％.Compared with non-AKI group,procalcitonin,IL-6,lactic acid,D-dimer,uric acid,NPR,neutrophil to lymphocyte ratio(NLR),neutrophil to lymphocyte and platelet ratio(N/LPR)in septic AKI group were significantly higher than those in septic non-AKI group,while the platelet count and lymphocyte count in sepsis group were significantly lower than those in non-AKI group(P＜0.05).Multivariate Logistic regression analysis showed that the increase of NPR,lactic acid,uric acid and the decrease of lymphocyte count were the independent risk factors of septic AKI.ROC curve analysis showed that NPR had good clinical value in predicting the occurrence of septic AKI.The area under the curve(AUC)was 0.731,which was better than that of NLR,but lower than N/LPR,and the predictive efficacy of N/LPR was also higher than that of the combination of NPR and NLR.Spearman corre-lation analysis showed that there was a positive correlation between NPR,N/LPR and AKI stage in patients with sepsis AKI.Conclusion The increase of admission NPR is an independent risk factor for septic AKI,which has a good predictive value,and high NPR is more closely related to the risk of severe AKI in septic AKI patients.NPR can predict the occurrence of septic AKI to some extent.

Objective To investigate the predictive value of lymphocyte count(LYM),interleukin-6(IL-6)and D-dimer(DD)combined detection on the 28 day prognosis of patients with sepsis.Methods Patients with sepsis 3.0 admitted to the People's Hospital of Xinjiang Uygur Autonomous Region from January 2023 to November 2023 were retrospectively selected.The clinical data of pa-tients were collected and divided into groups according to their survival at 28 days,and the levels of LYM,IL-6 and DD were compared.Draw the receiver operating characteristic(ROC)curve and calculate the area under the curve(AUC),the 28 days Kaplan-Meier sur-vival curve was plotted according to the cut-off value determined by the ROC curve.Results Finally,107 patients with sepsis were in-cluded,of which 66survived and 41 died within 28days.The levels of DD and IL-6 in the death group were significantly higher than those in the survival group,and the level of LYM was significantly lower than that in the survival group,and the difference between groups was statistically significant(P＜0.05).The results of multivariate COX regression analysis showed that LYM,IL-6 and DD were all risk factors for 28days death(P＜0.05).The results of ROC curve analysis showed that the AUC of LYM,IL-6 and DD combined detection was greater than that of single detection(0.909 vs 0.821,0.788,0.807).The results of Kaplan-Meier survival curve analysis showed that the 28days survival rate of patients with LYM≤0.52 × 109/L was significantly lower than that of patients with LYM＞0.52 × 109/L.The 28 days survival rate of patients with IL-6 ≥551.45pg/ml was significantly lower than that of patients with IL-6＜551.45pg/ml.The 28 days survival rate of patients with DD≥3.25mg/L was significantly lower than that of patients with DD＜3.25mg/L.Conclusion DD,IL-6 and LYM are all valuable in predicting the 28d prognosis of sepsis,and the combined detection of the three indicators is better than the single detection,which is expected to provide help for clinicians in the diagnosis and treatment of sepsis.