Objective To explore the diagnostic value of soluble C5b-9 (sC5b-9) for delayed graft function (DGF) following kidney transplantation. Methods Clinical data of 49 kidney transplant recipients who underwent sC5b-9 detection at the Second People’s Hospital of Shanxi Province between January 2024 and December 2025 were retrospectively analyzed. Recipients were divided into the DGF group (n=25) and the non-DGF group (n=24) according to the occurrence of DGF. Baseline characteristics and serum sC5b-9 levels were compared between the two groups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic efficacy of sC5b-9 for DGF. A restricted cubic spline model was adopted to investigate the association between sC5b-9 and DGF. Results Among the 49 recipients, DGF occurred in 25 patients. Compared with the non-DGF group, the DGF group presented a higher proportion of male patients, a higher incidence of adverse transplant outcomes, and elevated final serum creatinine levels (all P<0.05). Within 30 days after transplantation, sC5b-9 concentrations were significantly higher in the DGF group than those in the non-DGF group (P<0.001). ROC analysis revealed that the area under the curve (AUC) of sC5b-9 for diagnosing DGF was 0.81, with a 95% confidence interval (CI) of 0.68-0.92, and the optimal cutoff value was 265.7 ng/mL. Recipients with elevated sC5b-9 (≥265.7 ng/mL) had a significantly higher incidence of DGF than those with low sC5b-9 levels (<265.7 ng/mL) (P<0.001). Recipients with adverse outcomes exhibited significantly higher sC5b-9 levels than those without adverse outcomes (P<0.001), and the AUC of sC5b-9 for identifying adverse outcomes was 0.82 (95%CI 0.63-0.95). A significant nonlinear correlation was observed between sC5b-9 and final serum creatinine (P<0.001). Conclusions Elevated sC5b-9 is correlated with the development of DGF after kidney transplantation and exhibits favorable diagnostic performance. It may serve as a potential biomarker for predicting early allograft dysfunction and adverse outcomes in kidney transplant recipients.

Objective:To study the efficacy and success rate of dental pulp revascularization surgery for young permanent teeth with dental pulp necrosis.Method:A total of 100 young patients with dental pulp necrosis of permanent teeth admitted to Xixi Hospital of Hangzhou from March 2019 to March 2023 were selected prospectively, they were divided into the control group and the study group according to the principles of balance and randomization, with 50 cases in each group. The control group and the research group received apical induction shaping surgery and pulp revascularization surgery, respectively. The treatment success rate, root canal wall thickness, crown root ratio, and dental pulp vitality and development of the affected teeth before and after 6 months of treatment were compared between the two groups.Results:The success rate in the study group was higher than that in the control group : 94.00%(47/50) vs. 80.00%(40/50), there was statistical difference ( χ2 = 4.33, P<0.05). After 6 months of treatment, the thickness of the root canal wall in the study group was greater than that in the control group, the affected tooth crown root ratio was lower than that in the control group: (2.43 ± 0.42) mm vs. (2.25 ± 0.39) mm, 0.71 ± 0.09 vs. 0.78 ± 0.11, there were statistical differences ( P<0.05). The proportion of active dental pulp and secondary dental pulp development in the study group during the last follow-up were higher than those in the control group: 92.00%(46/50) vs. 76.00%(38/50), 94.00%(47/50) vs. 80.00%(40/50), there were statistical differences ( P<0.05). Conclusions:The use of dental pulp revascularization surgery in young permanent teeth with dental pulp necrosis can prolong the root of the affected tooth, thicken the root canal ratio, and improve the success rate of treatment by increasing dental pulp vitality and promoting root development.