Objective:To examine the effects of an improved mindfulness-based intervention program(IMIP)on depression,anxiety,psychological resilience,and marital quality among perinatal women.Methods:We enrolled 120 perinatal women receiving care at the obstetrics departments of Pudong Hospital and Nanhui Maternity and Child Health Hospital from December 2022 to August 2024.They were randomly assigned to either routine care group or IMIP group.The routine care group received standard prenatal care,while the IMIP group received,in addition to routine care,an eight-week course of IMIP intervention,administered once a week.Outcome mea-sures included the Edinburgh Postnatal Depression Scale(EPDS),Hospital Anxiety and Depression Scale(HADS),Connor-Davidson Resilience Scale(CD-RISC),and ENRICH Marital Satisfaction Scale,assessed at six time points—before intervention,after interven-tion(at 35 weeks of gestation),and at 3 days,42 days,3 months,and 6 months postpartum.A repeated measures ANOVA was con-ducted,with the score changes(Δ values)at individual time points from baseline as the dependent variable.Results:The IMIP group showed significantly greater improvements than the routine care group in EPDS,HADS-anxiety,CD-RISC,and ENRICH scores,with the main effects of group and time and their interaction effect all being significant(all P<0.001).For HADS-depression,the group×time interaction was not significant,but the main effect of group was significant(P<0.001).CD-RISC and ENRICH scores in-creased with time in the IMIP group.Conclusion:IMIP effectively alleviates depressive and anxiety symptoms,enhances psychological resilience,and improves marital quality for perinatal women,showing strong potential for clinical application.