SHCBP1 is a type of Src homologous collagen that can specifically bind to the SH2 structural domain. It can act as a key regulatory protein, and exhibits abnormally high expression in a variety of malignant tumors. Through affecting the processes such as cell cycle, proliferation, and invasion, it participates in tumor genesis and development. In addition, high expression of SHCBP1 is closely related to chemotherapy resistance and poor prognosis of many malignant tumors, and its targeted inhibition can enhance the sensitivity of chemotherapy and provide new therapeutic strategies for a variety of solid tumors, making it an important biomarker for prognostic assessment and a potential therapeutic target.

Objective To screen out the predictive factors for prognosis of migraine patients with patent foramen ovale(PFO)after occlusion,and to observe the value of predictive model based on these factors.Methods A total of 102 migraine patients with PFO who underwent occlusion of PFO were retrospectively included.Based on right to left shunt(RLS)grade in contrast-enhanced transcranial Doppler(TCD)and changes of migraine disability assessment(MIDAS)grade after occlusion,the patients were divided into effective group(n=56)and ineffective group(n=46).Patients'basic data and imaging data including contrast-enhanced TCD and transesophageal echocardiography(TEE)before occlusion were compared between groups.Independent predictive factors were screened using multivariate logistic regression,then a predictive model was established,and its performance was evaluated.Results Compared with ineffective group,effective group had a lower proportion of female patients,a higher proportion of patients with aura symptoms,also higher MIDAS scores before occlusion,lower left to right shunt(LRS)velocities through the defect,and higher RLS grades in contrast-enhanced TCD and TEE right heart contrast echocardiography before occlusion(all P＜0.05).Patients'gender,LRS velocity through the defect and RLS grade in TEE right heart contrast echocardiography before occlusion were all predictive factors for prognosis of migraine patients with PFO after occlusion of PFO(all P＜0.05).The established model demonstrated good discrimination,calibration and clinical net benefit.Conclusion Patients'gender,LRS velocity through the defect and RLS grade in TEE right heart contrast echocardiography before occlusion were all significant predictors of prognosis of migraine patients with PFO after occlusion,and the predictive model established based on these factors demonstrated certain clinical value.

Objective To screen out the predictive factors for prognosis of migraine patients with patent foramen ovale(PFO)after occlusion,and to observe the value of predictive model based on these factors.Methods A total of 102 migraine patients with PFO who underwent occlusion of PFO were retrospectively included.Based on right to left shunt(RLS)grade in contrast-enhanced transcranial Doppler(TCD)and changes of migraine disability assessment(MIDAS)grade after occlusion,the patients were divided into effective group(n=56)and ineffective group(n=46).Patients'basic data and imaging data including contrast-enhanced TCD and transesophageal echocardiography(TEE)before occlusion were compared between groups.Independent predictive factors were screened using multivariate logistic regression,then a predictive model was established,and its performance was evaluated.Results Compared with ineffective group,effective group had a lower proportion of female patients,a higher proportion of patients with aura symptoms,also higher MIDAS scores before occlusion,lower left to right shunt(LRS)velocities through the defect,and higher RLS grades in contrast-enhanced TCD and TEE right heart contrast echocardiography before occlusion(all P＜0.05).Patients'gender,LRS velocity through the defect and RLS grade in TEE right heart contrast echocardiography before occlusion were all predictive factors for prognosis of migraine patients with PFO after occlusion of PFO(all P＜0.05).The established model demonstrated good discrimination,calibration and clinical net benefit.Conclusion Patients'gender,LRS velocity through the defect and RLS grade in TEE right heart contrast echocardiography before occlusion were all significant predictors of prognosis of migraine patients with PFO after occlusion,and the predictive model established based on these factors demonstrated certain clinical value.

Objective To analyze the clinical and imaging features of hemichorea associated with non-ketotic hyperglycemia(HC-NH)and to explore the perfusion of cerebral blood flow in the patients.Methods A retrospective study was conducted on 23 HC-NH patients diagnosed in Henan Provincial People's Hospital from January 2018 to December 2023.The clinical manifesta-tions,imaging features and prognosis were collected and analyzed,and the correlation with cere-bral blood flow hypoperfusion was investigated.Results The symptoms were all lateral involun-tary movements,of which 4 cases presented only single upper limb(1 case was left upper limb,the other 3 cases were right upper limb),and 19 cases had both upper and lower limbs involved(10 cases were left limb,and 9 cases were right limb).After the onset of the symptoms,the blood glucose level was 19.72±4.72 mmol/L,glycated hemoglobin level was(13.60±3.68)％,but all of patients were negative to urine ketone bodies.Hyperdense lesions in the contralateral basal ganglia region on CT images were observed in 6 cases.Strip or patchy hyperintensity was seen on T1-weighted MR images.All patients had ipsilateral stenosis of the vessels and regional hypoperfu-sion of cerebral blood flow as shown by MR perfusion-weighted imaging.All symptoms were re-lieved after actively controlling blood glucose,improving blood circulation,and symptomatic man-agement.Conclusion HC-NH is quite rare in clinical practice,and its occurrence may be related to cerebral blood flow hypoperfusion triggered by basal nucleus degeneration.

Objective:To explore anxiety and impulsivity in adult female patients with anorexia nervosa (AN), and the relationship with different dimensions of the core clinical symptoms.Methods:From June 2014 to October 2022, 96 patients with AN, from both outpatient clinics and inpatient wards, were enrolled from Peking University Sixth Hospital. Additionally, 51 control participants were recruited from the community. State-trait Anxiety Inventory (STAI) and Barratt Impulsiveness Scale (BIS-11) were used to evaluate the anxiety and impulsivity of each group.The Eating Disorder Inventory-1 (EDI-1) was used to assess clinical and other psychological characteristics of ED.Correlation and regression analysis were employed to explore the relationship between anxiety, impulsivity, and core clinical symptoms of eating disorders.Results:(1) The total EDI-1 score for the AN group ((233.7±48.4) vs. (184.2±30.4), t=7.58, P<0.001) and scores in 7 subscales (Drive for Thinness: t=5.25, P<0.001; Bulimia: t=6.05, P<0.001; Ineffectiveness: t=7.91, P<0.001; Perfectionism: t=3.05, P=0.003; Interpersonal Distrust: t=5.50, P<0.001; Interoceptive Awareness: t=7.00, P<0.001; Maturity Fears: t=2.46, P=0.015) were significantly higher than the control group. (2) The AN group had significantly higher levels of state anxiety ( t=8.60, P<0.001), trait anxiety( t=7.40, P<0.001), total impulsivity( t=3.55, P<0.001), attentional impulsiveness( t=2.43, P=0.017) and motor impulsiveness( t=4.29, P<0.001) compared to the control group.(3)Correlation analysis showed that state anxiety, trait anxiety, attentional impulsiveness, motor impulsiveness, and non-planning impulsiveness were positively correlated with the drive for thinness( r=0.522, 0.577, 0.272, 0.387, 0.209, all P<0.05); State anxiety, trait anxiety, attentional impulsiveness, motor impulsiveness, and non-planning impulsiveness were also positively correlated with bulimia ( r=0.402, 0.471, 0.304, 0.514, 0.466, all P<0.01); Attentional impulsiveness, state anxiety, and trait anxiety were positively correlated with body dissatisfaction ( r=0.333, 0.448, 0.409, all P<0.01). Further ridge regression analysis indicated that trait anxiety in AN patients was an influencing factor of the drive for thinness ( t=3.13, P=0.002), state anxiety was an influencing factor of body dissatisfaction ( t=1.99, P=0.050), and motor impulsiveness and non-planning impulsiveness were the influencing factors of bulimia ( t=2.92, 2.79, all P<005). Conclusions:Patients with anorexia nervosa have higher anxiety and impulsivity, and the levels of anxiety and impulsivity in different dimensions are related to the core clinical symptoms of AN patients.

Objective To investigate the influencing factors for slowly progressive brainstem infarction and rapidly progressive brainstem infarction in patients with severe stenosis or occlusion of basilar artery.Methods A retrospective analysis was performed for 501 patients who attended Zhengzhou University People's Hospital from January 2013 to Decem-ber 2022 and were diagnosed with first-episode brainstem infarction after severe stenosis or occlusion of basilar artery by HR-MRI.The core volume of brainstem infarction was manually calculated,and the distribution of brainstem infarct vol-ume was analyzed.According to brainstem infarct volume and the time from stroke attack to imaging,the patients were di-vided into slowly progressive brainstem infarction group(0-<1 ml,6-24 hours)and rapidly progressive brainstem infarc-tion group(>5 ml,0-<6 hours),and the two groups were compared in terms of risk factors and collateral circula-tion.Results The 501 patients with severe stenosis or occlusion of basilar artery had a mean age of 66.14±10.37 years,among whom 39.13%were male patients.According to predefined thresholds,29 patients(16.29%)with severe stenosis or occlusion of basilar artery in the time window of 0-<6 hours were diagnosed with rapidly progressive brainstem infarc-tion,and 56 patients(17.34%)in the time window of 6-24 hours were diagnosed with slowly progressive brainstem infarc-tion.There were no significant differences between the two groups in the risk factors such as age,sex,NIHSS score,hy-pertension,diabetes,hyperlipidemia,and history of atrial fibrillation,coronary artery disease,and smoking.The Pear-son correlation analysis showed that collateral circulation in patients with severe stenosis or occlusion of the basilar artery was negatively correlated with rapidly progressive brainstem infarction(r=-0.619,P<0.001).Conclusions After se-vere stenosis or occlusion of the basilar artery,patients with good collateral circulation often have slowly progressive brain-stem infarction,while patients with poor collateral circulation often have rapidly progressive brainstem infarction.

Objective:To investigate the high-resolution MRI (HR-MRI) features and its correlation with ischemic stroke in patients with spontaneous vertebral artery dissection (sVAD).Methods:Consecutive patients with sVAD admitted to the People's Hospital of Zhengzhou University from January 2017 to January 2024 were included retrospectively. They were divided into stroke group and non-stroke group based on whether ischemic stroke was present or not. The vascular risk factors, clinical manifestations, vascular segments involved and HR-MRI features of the two groups were compared. Multivariate logistic regression analysis was used to determine the independent risk factors for ischemic stroke in patients with sVAD. Results:A total of 103 patients with sVAD were enrolled, including 59 males (57.3%), aged 46.40±3.73 years. 40 patients (38.8%) had concurrent stroke, while 63 (61.2%) did not. The proportion of patients with intramural hematoma, intramural hematoma T 1 isointensity, severe stenosis or occlusion, and intracranial segment involvement in the stroke group were significantly higher than those in the non-stroke group (all P<0.05). Multivariate logistic regression analysis suggests that severe stenosis or occlusion (odds ratio 2.623, 95% confidence interval 1.068-6.440; P=0.035) and intramural hematoma (odds ratio 2.842, 95% confidence interval 1.134-7.118; P=0.026) were the independent risk factors for ischemic stroke. Conclusions:Severe stenosis or occlusion and intramural hematoma shown by HR-MRI are the independent risk factors for ischemic stroke in patients with sVAD. Early identification of these factors may help with early intervention.

Objective:To investigate the pollution levels and influencing factors of polybrominated diphenyl ethers (PBDEs) in household dust in five cities in northern China.Methods:Based on the "Chinese Indoor Environment and Health Surveillance" project carried out by the National Institute of Environmental Health, Chinese Center for Disease Control and Prevention in 2018-2019, during the warm season (April 2018 to September 2018) and the cold season (November 2018 to March 2019), Lanzhou in Northwest China, Shijiazhuang in North China, Panjin in Northeast China, Luoyang in Central China, and Qingdao in East China were selected as the research sites. A total of 87 families were recruited to study residences in real-life scenarios. At the same time, dust samples were collected to detect the concentration of PBDEs. The level of household environmental indicators was measured, and the residential building characteristics and family behavior habits were collected through questionnaires. A total of 142 valid dust samples and 140 valid questionnaires were obtained. The differences in PBDE concentrations across seasons, wind zones, residential building characteristics, and family habits were analyzed. The exploratory factor analysis was performed to investigate the possible sources of PBDEs, and multivariate linear regression was used to explore the factors influencing PBDEs in household dust.Results:The M ( Q1,Q3) of total PBDE concentrations in 142 household dust samples in five cities was 144.51 (106.61, 222.65) ng/g in the warm season and 145.10 (98.57, 180.65) ng/g in the cold season, respectively. There were seasonal differences in the concentration of ∑ 12PBDEs in Luoyang and Shijiazhuang ( P<0.01). The concentration of BDE-71 was highest among PBDE homologues, followed by BDE-66 and BDE-47. Three factors were extracted by exploratory factor analysis in the warm season, and the cumulative variance contribution rate was 67.90%. The multivariate linear regression showed that the house completion less than ten years [ β (95% CI): 0.186 (0.013, 0.359)], infrequent home cooking [ β (95% CI):-0.342 (-0.570, -0.114)], and increased residential PM 10 concentration [ β (95% CI): 0.001 (0.000, 0.002)] during the warm season, as well as the house far from driveway [ β (95% CI): 0.093 (0.013, 0.172)], house area less than 90 m 2 [ β (95% CI):-0.138 (-0.264, -0.013)], and lower residential xylene concentration [ β (95% CI):-0.006 (-0.011, -0.001)] during the cold season might be related to the elevated concentrations of ∑ 12PBDEs in household dust. Conclusion:The pollution of PBDEs in household dust in five northern cities is at a medium to high level. Years of house completion, frequency of cooking at home, residential PM 10 concentration, distance from house to driveway, house area, and residential xylene concentration may influence household PBDE concentrations.

Objective To analyze the relationship of the volume of 87 brain regions with postnatal age and neurobehavior in full-term neonates.Methods A total of 75 full-term newborns[gestational age(39.38±1.22)weeks;male/female(51/24);postnatal age(11.11±6.67)days]without abnormalities on brain MRI(three-dimensional T1-weighted imaging,3D T1WI)at our hospital between November 2010 and September 2017 were retrospectively included.Based on the template of 87 brain regions,the neonatal brains were divided into 87 brain regions and their volumes were calculated by using V-shape Bottleneck network(VB-Net)deep learning segmentation technique,Pearson partial correlation and regression analysis were used to explore the relationship of the volume of each brain region with postnatal age and neurobehavioral scores.Results After adjusting for gestational age,birth weight,head circumference,body length and sex,66.7％of the regional brain volumes(58/87 brain regions)significantly increased with the postnatal age(correlation coefficient r:0.2-0.7,P＜0.05).The volumes of gray matter in bilateral lentiform nucleus,left caudate nucleus,right occipital lobe,right inferior temporal lobe,and bilateral anterior temporal lobe strongly correlated with the postnatal age(r＞0.50,P＜0.05).The gray matter volume of the right occipital lobe linearly increased with age(slope:100.67),and was positively correlated with behavioral scores(r=0.324,P＜0.01).Conclusion Most of regional brain volumes increase with the postnatal age during the neonatal period,and the fastest growth occurs in primary sensorimotor-related brain regions,presenting the spatial heterogeneity.Partial brain region grows with the development of behavioral ability.

Objective:To investigate the pollution levels and influencing factors of polybrominated diphenyl ethers (PBDEs) in household dust in five cities in northern China.Methods:Based on the "Chinese Indoor Environment and Health Surveillance" project carried out by the National Institute of Environmental Health, Chinese Center for Disease Control and Prevention in 2018-2019, during the warm season (April 2018 to September 2018) and the cold season (November 2018 to March 2019), Lanzhou in Northwest China, Shijiazhuang in North China, Panjin in Northeast China, Luoyang in Central China, and Qingdao in East China were selected as the research sites. A total of 87 families were recruited to study residences in real-life scenarios. At the same time, dust samples were collected to detect the concentration of PBDEs. The level of household environmental indicators was measured, and the residential building characteristics and family behavior habits were collected through questionnaires. A total of 142 valid dust samples and 140 valid questionnaires were obtained. The differences in PBDE concentrations across seasons, wind zones, residential building characteristics, and family habits were analyzed. The exploratory factor analysis was performed to investigate the possible sources of PBDEs, and multivariate linear regression was used to explore the factors influencing PBDEs in household dust.Results:The M ( Q1,Q3) of total PBDE concentrations in 142 household dust samples in five cities was 144.51 (106.61, 222.65) ng/g in the warm season and 145.10 (98.57, 180.65) ng/g in the cold season, respectively. There were seasonal differences in the concentration of ∑ 12PBDEs in Luoyang and Shijiazhuang ( P<0.01). The concentration of BDE-71 was highest among PBDE homologues, followed by BDE-66 and BDE-47. Three factors were extracted by exploratory factor analysis in the warm season, and the cumulative variance contribution rate was 67.90%. The multivariate linear regression showed that the house completion less than ten years [ β (95% CI): 0.186 (0.013, 0.359)], infrequent home cooking [ β (95% CI):-0.342 (-0.570, -0.114)], and increased residential PM 10 concentration [ β (95% CI): 0.001 (0.000, 0.002)] during the warm season, as well as the house far from driveway [ β (95% CI): 0.093 (0.013, 0.172)], house area less than 90 m 2 [ β (95% CI):-0.138 (-0.264, -0.013)], and lower residential xylene concentration [ β (95% CI):-0.006 (-0.011, -0.001)] during the cold season might be related to the elevated concentrations of ∑ 12PBDEs in household dust. Conclusion:The pollution of PBDEs in household dust in five northern cities is at a medium to high level. Years of house completion, frequency of cooking at home, residential PM 10 concentration, distance from house to driveway, house area, and residential xylene concentration may influence household PBDE concentrations.