Objective:To investigate the influence of age on the fresh cycle live birth rate in patients with poor ovarian response in different controlled ovarian hyperstimulation groups.Methods:The clinical data of 3 342 patients in The First Affiliated Hospital of Zhengzhou University from February 2014 to November 2018 were retrospectively collected, including early-follicular phase long-acting gonadotropin-releasing hormone (GnRH) agonist long protocol group (1 375 cases), mid-luteal phase short-acting GnRH agonist long protocol group (1 161 cases) and GnRH antagonist protocol group (806 cases); each group was divided into 4 subgroups according to age: ≤30 years, 31－35 years, 36－40 years and >40 years, the pregnancy outcomes in each age subgroup were analyzed under different controlled ovarian hyperstimulation protocols.Results:In early-follicular phase long-acting GnRH agonist long protocol group, the final live birth rates of each age subgroup were 39.4% (228/579), 36.1% (135/374), 16.6% (48/290) and 3.0% (4/132); in mid-luteal phase short-acting GnRH agonist long protocol group, live birth rates of each age subgroup were 32.1% (99/308), 20.8% (55/264), 13.0% (45/346) and 7.0% (17/243); in GnRH antagonist protocol group, live birth rates of each age subgroup were 22.8% (26/114), 16.3% (25/153), 11.2% (31/278), and 3.8% (10/261); the live birth rate of each group decreased significantly with the increase of age (all P<0.01). When the age≤35 years old, the fresh cycle live birth rate of the early-follicular phase long-acting GnRH agonist long protocol group was significantly better than those of the other two groups (all P<0.01). The multivariate logistic regression analysis of age and live birth rate of the three controlled ovarian hyperstimulation groups showed age was the independent influence factor ( OR=0.898, 95% CI: 0.873-0.916, P<0.01; OR=0.926, 95% CI: 0.890-0.996, P<0.01; OR=0.901, 95% CI: 0.863-0.960, P<0.01). Conclusions:Age is an independent influencing factor for the prediction of fresh cycle live birth rate in low ovarian response patients. No matter which controlled ovarian hyperstimulation protocol is adopted, the final live birth rate decreases significantly with the increase of women′s age. In addition, the early-follicular phase long-acting GnRH agonist long protocol has the highest fresh cycle live birth rate among all controlled ovarian hyperstimulation groups.

Objective To analyze dietary behavioral problems in children with an age from 3 to 10, who sought medical care in child healthcare outpatient , and also to discuss the role of masticatory function training in the improvement of children ′s dietary be-havioral problems , as well as related factors affecting intervention effects .Methods Those children aged from 3 to10 with dietary be-havioral problems were selected as our research objects , and were divided into groups in accordance with the age of their first visit and masticatory function training .Comprehensive methods such as questionnaire survey , clinical consultation ( personalized dietary behav-ioral instruction), distribution of dietary instructions, masticatory function training, periodic medical follow-ups by phone-calls, were used in the study.The results were analyzed and evaluated 3 months after intervention.Results From May 2015 to December 2014, a total of 120 eligible patients were recruited for the study , but only 104 children finally completed the study process .For the children of the school-age group , there were such dietary behavioral problems as having no interest , refusal of certain things , having no taste of a delicacy and showing favor for soft food , and statistical significance could be seen , as compared with those of the preschool group ( P<0.05).The ratio of improvement for dietary behavioral problems in most children increased with the increase of educational level of caretakers , as well as better compliance of medical advices .There were statistical differences in the ratio of improvement for dietary be-havioral problems in different masticatory function training groups , when comparisons were made between the groups (P<0.05), and statistical significance could be noted in changes of body weight and height , when comparisons were also made between the groups ( P=0.000).Conclusion The higher the educational level of their parents and the compatible the masticatory function training was , their dietary behavioral problems would be better improved .It was suggested that more attention should be paid to masticatory function train-ing, in addition to comprehensive analysis and intervention of those over 3-year-old children with dietary behavioral problems .When necessary, masticatory function training could be imposed on them , so as to improve their dietary habits.At the same time, more propa-ganda and education should be implemented on the caretakers .