Objective The aim of this study is to explore the practical value of prenatal magnetic resonance imaging(MRI)in the assessment of congenital cystic lung disease in fetuses,to evaluate the relative size of the lesion and the status of lung development,and to make an attempt at utilizing the strength of MRI in post-processing to obtain assessment indicators of the size of the lesion and the status of lung development,with which predictions can be made for the prognosis that these fetuses may face after birth.We retrospectively collected and analyzed the data of fetuses diagnosed with congenital cystic lung disease.Prenatal ultrasound examination of these fetuses led to the diagnosis that they were suspected of having congenital cystic lung disease and the diagnosis was confirmed by subsequent prenatal MRI.The fetuses were followed up to track their condition at birth(postnatal respiratory distress,mechanical ventilation,etc.),whether the fetuses underwent surgical treatment,and the recovery of the fetuses after surgical treatment.The recovery of the fetuses was followed up to explore the feasibility of prenatal MRI examination to assess fetal congenital pulmonary cystic disease,and to preliminarily explore the predictive value of prenatal MRI for the prognosis of fetuses with congenital pulmonary cystic disease.Methods MRI fetal images were collected from pregnant women who attended the West China Second University Hospital of Sichuan University between May 2018 and March 2023 and who were diagnosed with fetal congenital pulmonary cystic disease by prenatal ultrasound and subsequent MRI.Fetal MRI images of congenital cystic lung disease were post-processed to obtain the fetal lung lesion volume,the fetal affected lung volume,the healthy lung volume,and the fetal head circumference measurements.The signal intensity of both lungs and livers,the lesion volume/the affected lung volume,the lesion volume/total lung volume,the cystic volume ratio(CVR),and the bilateral lung-liver signal intensity ratio were measured.The feasibility and value of MRI post-processing acquisition indexes for evaluating the prognosis of fetuses with congenital cystic lung disease were further analyzed by combining the follow-up results obtained 6 months after the birth of the fetus.Logistic regression models were used to quantify the differences in maternal age,gestational week at the time of MRI,CVR,and bilateral lung-to-liver signal intensity ratio,and to assess whether these metrics correlate with poor prognosis.Receiver operating characteristic(ROC)curves were used to assess the value of the parameters obtained by MRI calculations alone and in combination with multiple metrics for predicting poor prognosis after birth.Results We collected a total of 67 cases of fetuses diagnosed with congenital cystic lung disease by fetal MRI between May 2018 and March 2023,and excluded 6 cases with no normal lung tissue in the affected lungs,11 cases of fetal induction,and 3 cases of loss of pregnancy.In the end,47 cases of fetuses with congenital cystic lung disease were included,of which 30 cases had a good prognosis and 17 cases had a poor prognosis.The difference in the difference between the signal intensity ratios of the affected and healthy sides of the lungs and livers of the fetuses in the good prognosis group and that in the poor prognosis group was statistically significant(P<0.05),and the signal intensity ratio of the healthy side of the lungs and livers was higher than the signal intensity ratio of the affected side of the lungs and livers.Further analysis showed that CVR(odds ratio[OR]=1.058,95% confidence interval[CI]:1.014-1.104),and the difference between the lung-to-liver signal intensity ratios of the affected and healthy sides(OR=0.814,95% CI:0.700-0.947)were correlated with poor prognosis of birth in fetuses with congenital cystic lung disease.In addition,ROC curve analysis showed that the combined application of lesion volume/affected lung volume and the observed difference in the signal intensity ratio between the affected and healthy lungs and liver predicted the prognosis of children with congenital cystic lung disease more accurately than the single-parameter judgment did,with the area under the curve being 0.988,and the cut-off value being 0.33,which corresponded to a sensitivity of 100%,a specificity of 93.3%,and a 95% CI of 0.966-1.000.Conclusions Based on the MRI of fetuses with congenital cystic lung disease,we obtained information on lesion volume,lesion volume/affected lung volume,lesion volume/total lung volume,CVR,and bilateral lung-to-liver signal intensity ratio difference,all of which showing some clinical value in predicting the poor prognosis in fetuses with congenital cystic lung disease.Furthermore,among the combined indexes,the lesion volume/affected lung volume and bilateral lung-to-liver signal intensity ratio difference are more effective predictors for the poor prognosis of fetuses with congenital cystic lung disease,and show better efficacy in predicting the poor prognosis of fetuses with congenital cystic lung disease.This provides a new and effective predictive method for further assessment of pulmonary lung development in fetuses with congenital cystic lung disease,and helps improve the assessment and prediction of the prognosis of fetuses with congenital cystic lung disease.

Objective:To study and develop the formulation of a plant material-based deodorant, and to evaluate its deodorization effect.Methods:This study developed a formulation of plant material-based deodorant, detected the main volatile components of plant essential oil, and tested the removal rate of ammonia, hydrogen sulfide, and methyl mercaptan.Results:Within the formulation, 33 active components were detected in the plant essential oil, most of which were oxygen-containing compounds. It was found that 6% of plant essential oil, 1.0% of β-cyclodextrin, and 3.0% of Tween-80 constituted the optimal formulation. The average purification efficiency of the plant material-based deodorant was higher than those of deionized water and chemical deodorant. At 10 minutes after spraying, the efficiency of eliminating hydrogen sulfide and methyl mercaptan of the plant material-based deodorant reached 100%; at 30 minutes after spraying, its efficiency of eliminating ammonia reached 95%.Conclusion:The plant material-based deodorant contains some functional groups of high reactive activity, which can react with odorous substances in various chemical ways to inhibit odors. Its effect of eliminating hydrogen sulfide and methyl mercaptan was better than that of eliminating ammonia.

Objective:To study and develop the formulation of a plant material-based deodorant, and to evaluate its deodorization effect.Methods:This study developed a formulation of plant material-based deodorant, detected the main volatile components of plant essential oil, and tested the removal rate of ammonia, hydrogen sulfide, and methyl mercaptan.Results:Within the formulation, 33 active components were detected in the plant essential oil, most of which were oxygen-containing compounds. It was found that 6% of plant essential oil, 1.0% of β-cyclodextrin, and 3.0% of Tween-80 constituted the optimal formulation. The average purification efficiency of the plant material-based deodorant was higher than those of deionized water and chemical deodorant. At 10 minutes after spraying, the efficiency of eliminating hydrogen sulfide and methyl mercaptan of the plant material-based deodorant reached 100%; at 30 minutes after spraying, its efficiency of eliminating ammonia reached 95%.Conclusion:The plant material-based deodorant contains some functional groups of high reactive activity, which can react with odorous substances in various chemical ways to inhibit odors. Its effect of eliminating hydrogen sulfide and methyl mercaptan was better than that of eliminating ammonia.

Objective To indentify the cognitive status of Chinese patients to acne and the influencing factors to theirs' cognitive status,so as to provide solid evidences for the prevention and treatment of acne.Methods A self-designed questionnaire was made to conduct this survey of 16,156 acne patients,who seeked to the treatment in the dermatological departments from 112 hospitals in China.The survey consisted of several parts,including the general status of patients,the patients' cognition of occurrence,development and risk factors of acne,whether the first choice was seeking treatment at the hospital when the patients had acne and the condition of selection of skin care products.The factors were analyzed,which could impact the cognition of the patients' behavior of treatment,how did the patients' cognition to influence their medical behavior and skin care as well as the consistency of assessment of the severity of acne by doctors and patients themselves.Results The acne patients studied had the best knowledge of "acne is a skin disease","it not only occurs in the period of adolescence" and "the disease can be prevented and cured",which accordingly accounted for 80.65％,69.16％ and 65.49％ of the total patients respectively.However,the awareness of acne patients to heredity,high sugar and dairy products as risk factors for acne was insufficient,which accounted for 48.72％,42.40％ and 18.25％ of the total patients,respectively.Gender,age,educational level,occupation and health knowledge were the main factors affecting the cognitive level of patients;the survey also found that men,patient with educational level of junior high or even lower educational condition,occupation of labor workers or farmers and patients were lack of health education with poor knowledge of the genetics and dietary were risk factors for acne;patients with age over 36 years or with mild illness had poor knowledge of dietary risk factors for acne;the difference was statistically significant (P＜0.05).The analysis of the influence of cognitive status on medical treatment behavior and skin care showed that the better the cognition,the higher the probability of patients would choose medical treatment as the first choice as well as choosing functional skin care products;the difference was statistically significant (P＜0.05).The consistency of assessment of the severity of acne by doctors and patients was poor (Kappa value ＜0.4),and the assessment of severity of acne by patients was more serious than doctors' assessment.Conclusions Patient's cognitive status will affect their medical behavior and skin care,and there is also a phenomenon that patients have a more serious assessment of their acne condition.It is suggested that health education for acne patients should be strengthened in clinical medicine so as to improve their knowledge of acne as well as preventing from acne effectively.

Objective To investigate the dose of docetaxel appropriate for patients with metastatic castration-resistant prostate cancer and its affects to the prognosis.Methods A retrospective analysis was performed on the clinical data of 75 patients with metastatic castration-resistant prostate cancer admitted from March 2010 to July 2016 who received docetaxel combined with prednisone chemotherapy.The patients were divided into the low-dose group (n =43,docetaxel ＜ 65 mg/m2),the middle-dose group (n =21,docetaxel 65-70 mg/m2) and the high-dose group (n =11,docetaxel ＞ 70 mg/m2).The median age in the low-dose group,middle-dose group and high-dose group was 67 (53-80),66 (56-78) and 61 (47-76) years old,respectively.Among 75 patients with bone metastasis,2 patients had no evidence of bone metastasis in the low-dose group.The lymph node metastasis was found in 26,13 and 6 cases in each group,respectively.And visceral and other metastasis were founded in 11,4 and 2 cases,respectively.The Gleason score in the low-dose group was≤7 points in 15 cases,≥8 points in 22 cases and no score in 6 cases.The Gleason score inthe middle-dose group was ≤7 points in 4 cases,≥8 points in 13 cases and no score in 4 cases.The Gleason score in the high-dose group was ≤7 points in 3 cases,≥8 points in 5 cases and no score in 3 cases.The number of patients with pain in the low-dose group,middle-dose group and high-dose group was 36,12 and 9,respectively,there were no significant differences in the above indicators (P ＞ 0.05),except age,which showed relatively more aged patients in the low-dose group,(P =0.045).Kaplan-Meier method was used to compare the overall survival (OS),progression-free survival (PFS) and the incidence of ≥CTCAE-4 grade 3 adverse reactions between the two groups.The Cox regression model was adopted to analyzed the factors that might affect patient prognosis,including the effective time of first-line endocrine therapy,hemoglobin level,ECOG score,pain score,number of cycles of chemotherapy,age,dose of docetaxel and alkaline phosphatase (ALP).Kaplan-Meier method was used to analyze the effect of dose of docetaxel on the prognosis,and log-rank method was used to test the significance of the results.Results The median OS was respectively 24.1,18.5 and 23.5 months in the low-dose group,middle-dose group and high-dose group,respectively.The median PFS was 5.3 months in all three groups,which didn't show statistically significant differences.The incidence of grade 3/4 adverse reactions in the low-dose group,middle-dose group and high-dose group was 15 cases (34.9％),8 cases (38.1％) and 5 cases (45.5％) respectively.It showed an increasing trend,but no statistically significant difference.The single factors related to OS mainly include the effective time of first-line endocrine therapy,hemoglobin level,ECOG score,pain score,number of cycles of chemotherapy,there was no significant correlation with age,docetaxel dose,ALP and PSA value.Conclusions It is common to receive lower doses of docetaxel in clinical practice for patients with metastatic castration-resistant prostate cancer in China.The efficacy of low-dose docetaxel is similar to that of high doses (standard dosage).There was no significant correlation between the OS and the actual dose of docetaxel in the tolerable range.

Objective To evaluate the efficacy and safety of the modified docetaxel plus prednisone scheme for the metastatic castration resistant prostate cancer patients who got poor tolerance to chemotherapy.Method The clinical data of 50 metastatic castration resistant prostate cancer who received docetaxel + prednisone chemotherapy from March 2010 to October 2015 were analyzed retrospectively.23 cases received the modified DP regimen (modified group),27 cases received the standard DP regimen (standard group).The median age of the modified group and the standard group were 69 years (47-80 years) and 63 years (52-77 years) (P =0.005).There were 19 and 24 cases with pain in modified group and standard group respectively;10 and 19 cases with lymph node metastasis respectively;3 and 4 cases of visceral metastasis respectively;all of the 50 patients were complicated with bone metastasis.For the pathological Gleason score,there were 7 cases scored ≤7 points,13 cases scored ≥ 8 points and 3 cases unscored in the modified group;7 cases scored ≤7 points,15 cases scored ≥8 points and 5 cases unscored in standard group.There was no significant difference of the pain,metastasis,and Gleason score between the two groups (P ＞ 0.05).Progression free survival (PFS),overall survival (OS)and adverse events were analyzed using Kaplan-Meier curves,and the differences were assessed using the log-rank test.Results In the modified group and standard group,the median follow-up times were 11.0 months and 14.0 months respectively,the median chemotherapy cycles were 4.5 cycles and 5.0 cycles respectively;OS were 18.0 months and 27.5 months respectively (P =0.746).The PFS of the two groups were 6.0 months and 5.2 months,respectively (P =0.822).The PSA response were 13 cases and 17 cases in the modified group and standard group respectively (P =0.615),and the pain response were 8 cases and 7 cases (P =0.927),grade 3 to 4 adverse events were 3 cases and 14 cases (P =0.003).The main adverse events were blood toxicity,neutrophils,gastrointestinal reaction,edema,fatigue and oral mucositis etc.Conclusions Compared with the standard DP scheme,the modified DP scheme had no significant difference in OS,PFS,pain response rate and PSA response rate,while the incidence of grade 3 to 4 adverse events was significantly reduced.Modified DP scheme may be a better choice for patients with metastatic castration resistant prostate cancer who get poor tolerance to chemotherapy.

Objective To investigate the effects of acute inhalation of fire extinguishing agent Novec 1230 on routine blood indexes and biochemical indexes in mice .Methods One hundred and twenty male ICR mice with an age range of 5 weeks and body mass of 18-22 g were randomly divided into the normal control group and the acute inhalation group , which were further divided into 3 subgroups , each consisting of 30 animals.The animals were exposed to the fire extinguishing agent Novec 1230 at concentration levels of 5%, 10%and 15%for 2 hours respectively , while the animals in the control group were exposed to common room air.Two time points ( at 2 hours and 14 days after inhalation exposure ) were set for each subgroups , which consisted of 15 mice.The routine blood levels and serum biochemical indexes of the mice were detected at the above 2 time points.Results Following exposure to the agent at levels of 5%, 10%and 15%for 2 hours, red blood cell (RBC) counts [(9.99 ±1.16) ×1012,(9.90 ±0.68) ×1012,(8.84 ±1.39) ×1012/L] decreased gradually with the increase in exposure concentrations , and statistical significance could be noted , when they were compared with those of the control group [(9.16 ±1.18)1012/L] (P<0.05).White blood cell (WBC) counts [(4.11 ±0.75) ×109,(6.23 ±1.05) ×109,(6.51 ±1.30) ×109/L] increased gradually with the increase in exposure concentrations , and statistical significance could be seen , when they were compared with those of the control group [(5.38 ±1.46) ×109/L] (P <0.05 or P <0.01).There were changes in hematocrit (HCT), mean corpuscular volume (MCV), platelet counts and hemoglobin (HGB), as compared with those of the control group , but without statistical significance (P<0.05).The levels of alkaline phosphate (ALP) [(218.67 ±0.85),(210.13 ±0.76)and(196.07 ±6.63)U/L] decreased gradually with the increase of exposure levels.The levels of alanine aminotransferase (ALT) were respectively [(51.50 ±1.40), (61.47 ±0.76) and (62.33 ±11.16)U/L], the levels of aspartate aminotransferase (AST) were respectively [(195.03 ±1.60)、(201.30 ±6.56)、(259.43 ±11.82)U/L] , and the levels of creatine kinase (CK) were respectively [(515.50 ±42.95),(834.60 ±76.20) and(915.63 ±24.18)U/L], which were increased with increase in exposure levels .Statistical significance could be observed , when they were compared with those of the control group [(184.97 ±2.46),(39.37 ±0.97),(187.70 ±2.51) and(452.20 ±93.01)U/L] (P<0. 05 or P<0.01).However,the differences in routine blood indexes and serum biochemical indexes were not statistically significant , when comparisons were made between the acute inhalation groups and the control group at day 14 after exposure(P>0.05).Conclusions Acute exposure of fire extinguishing agent Novec 1230 seemed to induce infectious damage , myocardial and heptal damage to mice , however , the damage afflicted on the animals seemed to recover 14 days after exposure .

Objective To investigate the effects of acute inhalation of fire extinguishing agent Novec 1230 on routine blood indexes and biochemical indexes in mice .Methods One hundred and twenty male ICR mice with an age range of 5 weeks and body mass of 18-22 g were randomly divided into the normal control group and the acute inhalation group , which were further divided into 3 subgroups , each consisting of 30 animals.The animals were exposed to the fire extinguishing agent Novec 1230 at concentration levels of 5%, 10%and 15%for 2 hours respectively , while the animals in the control group were exposed to common room air.Two time points ( at 2 hours and 14 days after inhalation exposure ) were set for each subgroups , which consisted of 15 mice.The routine blood levels and serum biochemical indexes of the mice were detected at the above 2 time points.Results Following exposure to the agent at levels of 5%, 10%and 15%for 2 hours, red blood cell (RBC) counts [(9.99 ±1.16) ×1012,(9.90 ±0.68) ×1012,(8.84 ±1.39) ×1012/L] decreased gradually with the increase in exposure concentrations , and statistical significance could be noted , when they were compared with those of the control group [(9.16 ±1.18)1012/L] (P<0.05).White blood cell (WBC) counts [(4.11 ±0.75) ×109,(6.23 ±1.05) ×109,(6.51 ±1.30) ×109/L] increased gradually with the increase in exposure concentrations , and statistical significance could be seen , when they were compared with those of the control group [(5.38 ±1.46) ×109/L] (P <0.05 or P <0.01).There were changes in hematocrit (HCT), mean corpuscular volume (MCV), platelet counts and hemoglobin (HGB), as compared with those of the control group , but without statistical significance (P<0.05).The levels of alkaline phosphate (ALP) [(218.67 ±0.85),(210.13 ±0.76)and(196.07 ±6.63)U/L] decreased gradually with the increase of exposure levels.The levels of alanine aminotransferase (ALT) were respectively [(51.50 ±1.40), (61.47 ±0.76) and (62.33 ±11.16)U/L], the levels of aspartate aminotransferase (AST) were respectively [(195.03 ±1.60)、(201.30 ±6.56)、(259.43 ±11.82)U/L] , and the levels of creatine kinase (CK) were respectively [(515.50 ±42.95),(834.60 ±76.20) and(915.63 ±24.18)U/L], which were increased with increase in exposure levels .Statistical significance could be observed , when they were compared with those of the control group [(184.97 ±2.46),(39.37 ±0.97),(187.70 ±2.51) and(452.20 ±93.01)U/L] (P<0. 05 or P<0.01).However,the differences in routine blood indexes and serum biochemical indexes were not statistically significant , when comparisons were made between the acute inhalation groups and the control group at day 14 after exposure(P>0.05).Conclusions Acute exposure of fire extinguishing agent Novec 1230 seemed to induce infectious damage , myocardial and heptal damage to mice , however , the damage afflicted on the animals seemed to recover 14 days after exposure .

OBJECTIVEThe progress in the compatibility and dismantlement research on Traditional Chinese compound prescription was involved to provide references for the exploitation and utilization of the Chinese herbs.

METHODThe major models, methods, objectives of the compatibility and dismantlement research on Traditional Chinese compound prescription were reviewed.

RESULTMultiple and crossing ways were used in the dismantlement study of compound and most of them are foundation studies of reasonable verification of the origin prescription.

CONCLUSIONThe compatibility and dismantlement research on Traditional Chinese compound prescription has extensive applied prospect and will be developed further.

Animals ; Disease Models, Animal ; Drug Combinations ; Drugs, Chinese Herbal ; administration & dosage ; isolation & purification ; pharmacology ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; Plants, Medicinal ; chemistry