Objective To explore adverse reactions induced by cyclosporine in patients with rheumatic diseases. Methods Clinical data of patients diagnosed with rheumatic diseases and treated with cyclosporine( 3 d)in Peking University First Hospital from January 2013 to December 2014 were collected and analyzed retrospectively. Results Data of a total of 46 patients in accordance with inclusion criteria were collected. Of them, 20 patients were diagnosed with systemic lupus erythematosus, 8 with dermatomyositis,6 with sicca syndrome,and 4 with undifferentiated connective tissue diseases and etc. There were 2-13 kinds of combination drugs in this 46 patients. In addition to cyclosporine treatment,all of them were treated with glucocorticoid,39 with non-steroidal antiinflammatory drugs,12 with other immune suppressants,20 with antibiotics,15 with hypoglycemic drugs,14 with antihypertensive drugs,and 8 with proton pump inhibitors at the same time. Of the 46 patients,21 developed 33 patient-time adverse drug reactions and the incidence was 45. 7%. Of the 21 patients,14 patients developed 1 kind of adverse reaction,3 patients developed 2 kinds of adverse reactions,3 patients developed 3 kinds of adverse reactions,and 1 patients developed 4 kinds of adverse reactions. The incidence of different adverse reactions were as follow:infection 21. 7%(10/46),urea nitrogen increase 10. 9%(5/46),gastrointestinal reactions 10. 9%(5/46),blood glucose increase 8. 7%(4/46),blood pressure increase 8. 7%(4/46),and liver injury 6. 5%(3/46),dizziness and headache 2. 2%(1/46),and hypoleucocytosis 2. 2%(1/46). Severe adverse reactions occurred in 5 patients and in 4 of them improved after treatments with drug withdrawal or symptomatic therapy,including recurrence of pulmonary tuberculosis in 2 patients,aggravation of original interstitial lung disease in 1 patient,and peptic ulcer in 1 patient;the fifth patient with repetitive infection died of primary disease after drug withdrawal. Moderate adverse reactions in 8 patients improved after symptomatic treatments. Mild adverse reactions in 7 patients were self-relieved and not clear in 1 patient because of discharge. Conclusions The incidence of adverse reactions induced by cyclosporine is high. The incidence of infection is higher and more severe. During the treatments,infection,blood glucose,blood pressure,and liver and renal function should be monitored to ensure medication safety.

Objective To explore adverse reactions induced by cyclosporine in patients with rheumatic diseases. Methods Clinical data of patients diagnosed with rheumatic diseases and treated with cyclosporine( 3 d)in Peking University First Hospital from January 2013 to December 2014 were collected and analyzed retrospectively. Results Data of a total of 46 patients in accordance with inclusion criteria were collected. Of them, 20 patients were diagnosed with systemic lupus erythematosus, 8 with dermatomyositis,6 with sicca syndrome,and 4 with undifferentiated connective tissue diseases and etc. There were 2-13 kinds of combination drugs in this 46 patients. In addition to cyclosporine treatment,all of them were treated with glucocorticoid,39 with non-steroidal antiinflammatory drugs,12 with other immune suppressants,20 with antibiotics,15 with hypoglycemic drugs,14 with antihypertensive drugs,and 8 with proton pump inhibitors at the same time. Of the 46 patients,21 developed 33 patient-time adverse drug reactions and the incidence was 45. 7%. Of the 21 patients,14 patients developed 1 kind of adverse reaction,3 patients developed 2 kinds of adverse reactions,3 patients developed 3 kinds of adverse reactions,and 1 patients developed 4 kinds of adverse reactions. The incidence of different adverse reactions were as follow:infection 21. 7%(10/46),urea nitrogen increase 10. 9%(5/46),gastrointestinal reactions 10. 9%(5/46),blood glucose increase 8. 7%(4/46),blood pressure increase 8. 7%(4/46),and liver injury 6. 5%(3/46),dizziness and headache 2. 2%(1/46),and hypoleucocytosis 2. 2%(1/46). Severe adverse reactions occurred in 5 patients and in 4 of them improved after treatments with drug withdrawal or symptomatic therapy,including recurrence of pulmonary tuberculosis in 2 patients,aggravation of original interstitial lung disease in 1 patient,and peptic ulcer in 1 patient;the fifth patient with repetitive infection died of primary disease after drug withdrawal. Moderate adverse reactions in 8 patients improved after symptomatic treatments. Mild adverse reactions in 7 patients were self-relieved and not clear in 1 patient because of discharge. Conclusions The incidence of adverse reactions induced by cyclosporine is high. The incidence of infection is higher and more severe. During the treatments,infection,blood glucose,blood pressure,and liver and renal function should be monitored to ensure medication safety.