Objective To observe the value of intravascular ultrasound elastography(IVUSE)for evaluating efficacy of ezetimibe combined with rosuvastatin for treating carotid atherosclerotic plaques.Methods Totally 200 ischemic cerebrovascular disease patients were prospectively enrolled and randomly divided into study group and control group(each n=100).Patients in study group were treated with ezetimibe combined with rosuvastatin,while those in control group were treated with atorvastatin alone for 4 months.The score of National Institutes of Health stroke scale(NIHSS)and related indicators of laboratory examination were recorded before and after treatment.Routine carotid artery ultrasound and IVUSE examination were performed,their efficacy for detecting vulnerable carotid plaque were compared taken the results of digital subtraction angiography(DSA)and CT before treatment as standards.The changes of clinical data,IVUSE parameters and stability of carotid plaque after treatment were observed.Results DSA detected single plaque in 162 cases and multiple plaques in 38 cases,with a total of 232 plaques,including 192 vulnerable plaques and 40 stable plaques.The accuracy of IVUSE for detecting vulnerable carotid plaque was higher than that of conventional ultrasound(x2=16.019,P＜0.001).After treatment,NIHSS score,total cholesterol,triglycerides,low-and high-density lipoprotein cholesterol improved better in study group than those in control group.Eccentric index and strain rate were higher,while the other plaque IVUSE parameters were lower in study group than those in control group(all P＜0.05).The improvement rate of plaque stability in study group after treatment was higher than that in control group(78.00％[78/100]vs.52.00％[52/100],P＜0.001).Conclusion IVUSE could be used to evaluate the efficacy of ezetimibe combined with rosuvastatin for treating carotid atherosclerotic plaque.

Objective To observe the value of intravascular ultrasound elastography(IVUSE)for evaluating efficacy of ezetimibe combined with rosuvastatin for treating carotid atherosclerotic plaques.Methods Totally 200 ischemic cerebrovascular disease patients were prospectively enrolled and randomly divided into study group and control group(each n=100).Patients in study group were treated with ezetimibe combined with rosuvastatin,while those in control group were treated with atorvastatin alone for 4 months.The score of National Institutes of Health stroke scale(NIHSS)and related indicators of laboratory examination were recorded before and after treatment.Routine carotid artery ultrasound and IVUSE examination were performed,their efficacy for detecting vulnerable carotid plaque were compared taken the results of digital subtraction angiography(DSA)and CT before treatment as standards.The changes of clinical data,IVUSE parameters and stability of carotid plaque after treatment were observed.Results DSA detected single plaque in 162 cases and multiple plaques in 38 cases,with a total of 232 plaques,including 192 vulnerable plaques and 40 stable plaques.The accuracy of IVUSE for detecting vulnerable carotid plaque was higher than that of conventional ultrasound(x2=16.019,P＜0.001).After treatment,NIHSS score,total cholesterol,triglycerides,low-and high-density lipoprotein cholesterol improved better in study group than those in control group.Eccentric index and strain rate were higher,while the other plaque IVUSE parameters were lower in study group than those in control group(all P＜0.05).The improvement rate of plaque stability in study group after treatment was higher than that in control group(78.00％[78/100]vs.52.00％[52/100],P＜0.001).Conclusion IVUSE could be used to evaluate the efficacy of ezetimibe combined with rosuvastatin for treating carotid atherosclerotic plaque.

Aiming at the problem of the influence of preloading force on its mechanical response in soft tissue compression experiments, an elimination method of preloading force based on linear loading region is proposed. Unconfined compression experiments under a variety of different preloading forces are performed. The influence of the preloading force on the parameters of constitutive model is analyzed. In the preload phase, the mechanical response of the soft tissue is taken as a linear model. The preloading force is eliminated by taking the preloading phase into account throughout the response process. According to five different preloading forces of the unconfined compression experiments, the elimination method is validated with two different constitutive models of soft tissue, and the error between the models obtained by the preloading force elimination method and the traditional method with the experimental results is compared. The results show that the error obtained by preloading force elimination method is significantly smaller than the traditional method. The preloading force elimination method can eliminate the influence of preloading force on mechanical response to a certain extent, and constitutive model parameters which are closer to the true properties of soft tissue can be obtained.
Elasticity ; Linear Models ; Models, Biological ; Pressure ; Stress, Mechanical

Objective To investigate the clinical efficacy of thoracoscopic and laparoscopic radical resection for adenocarcinoma of the esophagogastric junction (AEG) with side-to-side tubular gastroesophagostomy.Methods The retrospective and descriptive study was conducted.The clinicopathological data of 4 patients with AEG who were admitted to the First Affiliated Hospital of Xiamen University between November 2017 and June 2018 were collected.All the patients underwent thoracoscopic and laparoscopic radical resection for AEG using side-to-side tubular gastroesophagostomy and received 6 cycles of postoperative adjuvant chemotherapy with SOX regimen.Observation indicators:(1) surgical and postoperative recovery situations;(2) postoperative pathological examination;(3) follow-up and survival situations.The follow-up using outpatient examination and telephone interview was performed to detect postoperative adjuvant therapy situations and survival of patients up to Semptember 2018.Results (1) Surgical and postoperative recovery situations:4 patients successfully underwent thoracoscopic and laparoscopic radical resection for AEG using side-to-side tubular gastroesophagostomy,without conversion to thoracotomy,open surgery or perioperative death.Operation time,volume of intraoperative blood loss,time for postoperative fluid diet intake and postoperative drainage-tube removal time of case 1,2,3,4 were respectively 420 minutes,400 minutes,320 minutes,300 minutes and 100 mL,100 mL,150 mL,100 mL and 9 days,8 days,8 days,8 days and 11 days,10 days,10 days,10 days.Case 1 with mild pneumonia and hiccup and case 2 with mild pneumonia were improved by symptomatic treatment,case 3 and 4 didn't have complication.All the patients had postoperative patent anastomosis.Duration of postoperative hospital stay of case 1,2,3,4 were respectively 12 days,11 days,11 days,11 days.(2) Postoperative pathological examination:all the 4 patients had negative surgical margin.Number of lymph node dissected,number of positive lymph node,tumor diameter,Siewert type,depth of tumor infiltration,tumor histopathologic stage of case 1,2,3,4 were respectively 32,31,17,23 and 0,4,2,6 and 3.5 cm,5.0 cm,5.0 cm,4.0 cm and type Ⅱ,Ⅰ,Ⅱ,Ⅰ and subserosa,entire wall of the esophagogastric junction,subserosa,entire wall of the esophagogastric junction and Ⅱ A staging,Ⅲ B staging,Ⅱ B staging,Ⅲ A staging.Degree of tumor differentiation and pathological type were moderately differentiated adenocarcinoma in the 4 patients.(3) Follow-up and survival situations:4 patients were followed up for 3-10 months,with a median time of 5 months.During the follow-up,4 patients underwent chemotherapy and achieved disease-free survival.Conclusion Thoracoscopic and laparoscopic radical resection for AEG using side-to-side tubular gastroesophagostomy is safe and feasible.

ObjectiveTo observe the clinical effect of Kangxiuke apozem in the treatment of severe bum shock.Methods40 patients of severe burn shock were randomly divided into a treatment group and a control group,with 20 patients in each group.All the patients were treated by the same route of counter-shock therapy,and the treatment group was additionally given Kangxiuke apozem (nasal feeding,qd,150 ml/d).Level of blood lactic acid,heart rate and urinary volume were evaluated by time.Main shock symptoms,including restlessness,hydrodipsia,perspiration and coldness,were observed.ResultsThe treatment group was significantly superior to the control group in the amelioration of blood lactic acid,heart rate and urinary volume ( t =10.485、3.219、7.429,P＜ 0.01 ).The symptomatic extinction of restlessness,hydrodipsia,perspiration and coldness in the extremities in the treatment group were significantly superior to those in the control group (x2=10.16、7.37、5.63、4.29,P＜0.05).ConclusionAt the same time of routine counter-shock therapy,thereby prompt burn patients to smoothly go through shock period and decreas late complications.