Objective:To systematically analyze the reasons for delayed medical consultation in cervical cancer patients, providing a reference basis for promoting timely medical consultation and early treatment for cervical cancer patients.Methods:A computer-based search was conducted across various databases, including China National Knowledge Infrastructure, Wanfang Data, VIP, China Biology Medicine disc, PubMed, Web of Science, Embase, CINAHL, and Cochrane Library, for qualitative studies on delayed medical consultation in cervical cancer patients. The search covered all available records up to June 30, 2024. The Joanna Briggs Institute centre for evidence-based health care qualitative research quality assessment criteria was used to assess the quality of the included studies, and an integrative synthesis method was applied to combine the findings.Results:A total of 11 studies were included, with 36 individual findings. These findings were grouped into 13 new categories. A total of three major synthesized results were identified: insufficient awareness of cervical cancer, barriers to medical consultation behavior, and the influence of social factors.Conclusions:Strengthening the promotion of cervical cancer health knowledge, providing psychosocial support for patients, and establishing robust social support systems are essential strategies to facilitate timely medical consultation and early treatment for cervical cancer patients.

Objective:To systematically analyze the reasons for delayed medical consultation in cervical cancer patients, providing a reference basis for promoting timely medical consultation and early treatment for cervical cancer patients.Methods:A computer-based search was conducted across various databases, including China National Knowledge Infrastructure, Wanfang Data, VIP, China Biology Medicine disc, PubMed, Web of Science, Embase, CINAHL, and Cochrane Library, for qualitative studies on delayed medical consultation in cervical cancer patients. The search covered all available records up to June 30, 2024. The Joanna Briggs Institute centre for evidence-based health care qualitative research quality assessment criteria was used to assess the quality of the included studies, and an integrative synthesis method was applied to combine the findings.Results:A total of 11 studies were included, with 36 individual findings. These findings were grouped into 13 new categories. A total of three major synthesized results were identified: insufficient awareness of cervical cancer, barriers to medical consultation behavior, and the influence of social factors.Conclusions:Strengthening the promotion of cervical cancer health knowledge, providing psychosocial support for patients, and establishing robust social support systems are essential strategies to facilitate timely medical consultation and early treatment for cervical cancer patients.

Orthodontic tooth movement elicits alveolar bone remodeling and orofacial pain that is manifested by tooth mechanical hyperalgesia. Nerve growth factor (NGF) is upregulated in periodontium and may modulate tooth mechanical hyperalgesia. The objectives were to examine the role of NGF in tooth mechanical hyperalgesia and to elucidate the underlying mechanisms. Tooth mechanical hyperalgesia was induced by ligating closed coil springs between incisors and molars in Sprague-Dawley rats. Retrograde labeling was performed by periodontal administration of fluor-conjugated NGF and the detection of fluorescence in trigeminal ganglia (TG). Lentivirus vectors carrying NGF shRNA were employed to knockdown the expression of NGF in TG. The administration of agonists, antagonists, and virus vectors into TG and periodontium was conducted. Tooth mechanical hyperalgesia was examined through the threshold of biting withdrawal. Our results revealed that tooth movement elicited tooth mechanical hyperalgesia that could be alleviated by NGF neutralizing antibody and that NGF was upregulated in periodontium (mainly in periodontal fibroblasts) and TG. Retrograde labeling revealed that periodontal NGF was retrogradely transported to TG after day 1. Acid-sensing ion channel 3 (ASIC3) and NGF were co-expressed in trigeminal neurons and the percentage of co-expression was significantly higher following tooth movement. The administration of NGF and NGF neutralizing antibody into TG could upregulate and downregulate the expression of ASIC3 in TG, respectively. NGF aggravated tooth mechanical hyperalgesia that could be alleviated by ASIC3 antagonist (APETx2). Moreover, NGF neutralizing antibody mitigated tooth mechanical hyperalgesia that could be recapitulated by ASIC3 agonist (GMQ). NGF-based gene therapy abolished tooth mechanical hyperalgesia and downregulated ASIC3 expression. Taken together, in response to force stimuli, periodontal fibroblasts upregulated the expressions of NGF that was retrogradely transported to TG, where NGF elicited tooth mechanical hyperalgesia through upregulating ASIC3. NGF-based gene therapy is a viable method in alleviating tooth-movement-induced mechanical hyperalgesia.