Objective To explore the clinical efficacy of using 3D patches to repair inguinal hernia in laparoscopic transabdominal preperitoneal inguinal hernia repair(TAPP).Methods A retrospective study was conducted on 102 patients with inguinal hernia.All the patients were treated with laparoscopic TAPP.The patients were divided into two groups based on the different patch methods used after the surgery.The patients who used ordinary patches were in the ordinary patch group(n=50),and the patients who used 3D patches were in the 3D patch group(n=52).The surgery-related conditions,postoperative pain,postoperative complications and recurrence of the two groups of patients were compared.Results The 3D patch group had shorter surgery time,first exhaust time,got out of bed mobility time,less hospital stay and intraoperative bleeding volume than those in the ordinary patch group,the differences were statistically significant(P<0.05).On the 1,3,and 5 d after surgery,the visual analogue scale(VAS)scores of patients in the 3D patch group were lower than those in the ordinary patch group,the differences were statistically significant(P<0.05).The total complications rate in the 3D patch group was 5.77%,which was significantly lower than the 20.00%in the ordinary patch group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the postoperative recurrence rate between the two groups of patients(P>0.05).Conclusion For patients with inguinal hernia,administering 3D hernia patches during laparoscopic TAPP can reduce intraoperative bleeding volume,alleviate postoperative pain,and lower the complications rate such as postoperative urinary retention,scrotal edema,and seroma.It is worthy of clinical promotion and application.

Objective To explore the clinical efficacy of using 3D patches to repair inguinal hernia in laparoscopic transabdominal preperitoneal inguinal hernia repair(TAPP).Methods A retrospective study was conducted on 102 patients with inguinal hernia.All the patients were treated with laparoscopic TAPP.The patients were divided into two groups based on the different patch methods used after the surgery.The patients who used ordinary patches were in the ordinary patch group(n=50),and the patients who used 3D patches were in the 3D patch group(n=52).The surgery-related conditions,postoperative pain,postoperative complications and recurrence of the two groups of patients were compared.Results The 3D patch group had shorter surgery time,first exhaust time,got out of bed mobility time,less hospital stay and intraoperative bleeding volume than those in the ordinary patch group,the differences were statistically significant(P<0.05).On the 1,3,and 5 d after surgery,the visual analogue scale(VAS)scores of patients in the 3D patch group were lower than those in the ordinary patch group,the differences were statistically significant(P<0.05).The total complications rate in the 3D patch group was 5.77%,which was significantly lower than the 20.00%in the ordinary patch group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the postoperative recurrence rate between the two groups of patients(P>0.05).Conclusion For patients with inguinal hernia,administering 3D hernia patches during laparoscopic TAPP can reduce intraoperative bleeding volume,alleviate postoperative pain,and lower the complications rate such as postoperative urinary retention,scrotal edema,and seroma.It is worthy of clinical promotion and application.

Obj ective To explore the relationship between xeroderma pigmentosum group D (ERCC2/XPD),Bcl-2 associated athanogene 1 (BAG-1 )and DNA repair gene RAD5 1 polymor-phism and clinicopathological characteristics of non-small cell lung cancer (NSCLC).Methods A case-control study with 100 NSCLC cases and 80 controls matched by age and sex was conducted, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP )was ana-lyzed.Logistic regression model was made to calculate the odd ratios (ORs)and detect 95%confi-dence intervals (CIs)of ERCC2/XPD Lys751Gln,BAG-1codon 324 and RAD51 codon 135 with susceptibility of NSCLC.Unconditional Logistic regression model adj usted by the confounding fac-tors was used to analyze the correlation between the polymorphism genotypes and the risk of NSCLC and clinicopathological characteristics.Results The odds ratios for individuals carrying ERCC2/XPD C/A and A/A were 1.53(95%CI:1.15~3.32)and 0.58 (95% CI:0.15~2.39).The odds ratios for individuals carrying BAG-1 C/T was 1.28(95%CI:1.08~2.74).The odds ratios for individuals carrying RAD51 G/C was 1.03(95%CI:1.06~2.29).ERCC2/XPD C/A and A/A polymorphisms genotype frequencies were significantly related to the invasive characteristics of NSCLC [lymph node metastasis:(P= 0.038,OR= 2.26,95% CI:1.69~3.59),distant metastasis:(P= 0.005,OR= 2.47,95%CI:1.38~4.24)].As the same BAG-1 codon 324 C/T and RAD51 codon 135 G/C polymorphisms genotype frequencies (P= 0.042,OR= 2.57, 95%CI:1.62~4.44 and P= 0.049,OR= 2.86,95%CI:1.39~3.62).Conclusion Genet-icpolymorphism of ERCC2/XPD,BAG-1 and RAD5 1 are associated with the susceptibility to NSCLC.ERCC2/XPD,BAG-1 and RAD51gene polymorphism in Chinese Han population in-creases susceptibility to NSCLC risk and the changes of ERCC2/XPD C/A and A/A,BAG-1codon 324 C/T and RAD51 codon 135 G/C polymorphism are closely related to lymph node and distant metastasis.

Obj ective To explore the relationship between xeroderma pigmentosum group D (ERCC2/XPD),Bcl-2 associated athanogene 1 (BAG-1 )and DNA repair gene RAD5 1 polymor-phism and clinicopathological characteristics of non-small cell lung cancer (NSCLC).Methods A case-control study with 100 NSCLC cases and 80 controls matched by age and sex was conducted, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP )was ana-lyzed.Logistic regression model was made to calculate the odd ratios (ORs)and detect 95%confi-dence intervals (CIs)of ERCC2/XPD Lys751Gln,BAG-1codon 324 and RAD51 codon 135 with susceptibility of NSCLC.Unconditional Logistic regression model adj usted by the confounding fac-tors was used to analyze the correlation between the polymorphism genotypes and the risk of NSCLC and clinicopathological characteristics.Results The odds ratios for individuals carrying ERCC2/XPD C/A and A/A were 1.53(95%CI:1.15~3.32)and 0.58 (95% CI:0.15~2.39).The odds ratios for individuals carrying BAG-1 C/T was 1.28(95%CI:1.08~2.74).The odds ratios for individuals carrying RAD51 G/C was 1.03(95%CI:1.06~2.29).ERCC2/XPD C/A and A/A polymorphisms genotype frequencies were significantly related to the invasive characteristics of NSCLC [lymph node metastasis:(P= 0.038,OR= 2.26,95% CI:1.69~3.59),distant metastasis:(P= 0.005,OR= 2.47,95%CI:1.38~4.24)].As the same BAG-1 codon 324 C/T and RAD51 codon 135 G/C polymorphisms genotype frequencies (P= 0.042,OR= 2.57, 95%CI:1.62~4.44 and P= 0.049,OR= 2.86,95%CI:1.39~3.62).Conclusion Genet-icpolymorphism of ERCC2/XPD,BAG-1 and RAD5 1 are associated with the susceptibility to NSCLC.ERCC2/XPD,BAG-1 and RAD51gene polymorphism in Chinese Han population in-creases susceptibility to NSCLC risk and the changes of ERCC2/XPD C/A and A/A,BAG-1codon 324 C/T and RAD51 codon 135 G/C polymorphism are closely related to lymph node and distant metastasis.