Schizophrenia is a common, severe, and complex psychiatric disorder worldwide. Genetic factors account for around 80% of the etiology of schizophrenia, yet objective diagnostic biomarkers remain lacking. This article reports two cases of female monozygotic twins diagnosed with schizophrenia, exhibiting a balanced translocation between 22q11.2 and 4p15.3. Reviewing the literature, we analyze and discuss the correlation between chromosomal balanced translocation regions and the pathogenesis of mental disorders. This aims to encourage psychiatrists to consider new perspectives on the diagnosis of schizophrenia.

Schizophrenia is a common, severe, and complex psychiatric disorder worldwide. Genetic factors account for around 80% of the etiology of schizophrenia, yet objective diagnostic biomarkers remain lacking. This article reports two cases of female monozygotic twins diagnosed with schizophrenia, exhibiting a balanced translocation between 22q11.2 and 4p15.3. Reviewing the literature, we analyze and discuss the correlation between chromosomal balanced translocation regions and the pathogenesis of mental disorders. This aims to encourage psychiatrists to consider new perspectives on the diagnosis of schizophrenia.

Objective:To construct the training program system for hospice care volunteers and provide reference for the training of hospice care volunteers in China.Methods:The training program system for hospice care volunteers was initially determined by using the method of literature analysis and investigation, and 16 experts were consulted by two rounds of letters using the method of expert inquiry from May to July 2022, and finally the training program system was established.Results:The effective recovery rate of the two rounds of expert consultation questionnaire was 100%, the expert authority coefficient was 0.88, and the Kendall coordination coefficient was 0.141, 0.131 (both P<0.05). The final training program system for hospice care volunteers contained 7 first-class indicators including training objectives, training objects, training contents, training methods, training hours, training resources and training evaluation, 27 second-class indicators and 92 third-class indicators. Conclusions:The training program system for hospice care volunteers constructed in this study has high reliability and scientificity, and has a good guiding role and reference value for the training of hospice care volunteers.

Deepening the ideological and political construction of curriculum and carrying out the fundamental task of cultivating people with morality are the important requirements of education reform and talent cultivation in the new era. Microbiology Experiment is an important basic course and core practice course of Bioengineering, Pharmaceutical Engineering, Food Science and Engineering, et al. In order to give full play to the education function of Microbiology Experiment, this article deeply developed the ideological elements contained in the curriculum referring to the guidelines for the construction of ideological and political courses in institutions of higher education. And the article explored the ideological and political reform of Microbiology Experiment from three aspects: teaching content reform, teaching method innovation and improvement of teachers' ideological and political construction ability. Strive to integrate the value shaping, knowledge transference and ability training, cultivate high-quality professionals with firm ideals and beliefs.
Curriculum ; Humans ; Universities

OBJECTIVE: To determine the carrier rate of deafness-related genetic variants among 53 873 newborns from Zhengzhou. METHODS: Heel blood samples of the newborns were collected with informed consent from the parents, and 15 loci of 4 genes related to congenital deafness were detected by microarray. RESULTS: In total 2770 newborns were found to carry deafness-related variants, with a carrier rate of 5.142%. 1325 newborns (2.459%) were found to carry heterozygous variants of the GJB2 gene, 1071 (1.988%) were found with SLC26A4 gene variants, 205 were found with GJB3 gene variants (0.381%), and 120 were found with 12S rRNA variants (0.223%). Five newborns have carried homozygous GJB2 variants, two have carried homozygous SLC26A4 variants, five have carried compound heterozygous GJB2 variants, and four have carried compound heterozygous SLC26A4 variants. 33 neonates have carried heterozygous variants of two genes at the same time. CONCLUSION The carrier rate of deafness-related variants in Zhengzhou, in a declining order, is for GJB2, SLC26A4, GJB3 and 12S rRNA. The common variants included GJB2 235delC and SLC26A4 IVS7-2A>G, which are similar to other regions in China. To carry out genetic screening of neonatal deafness can help to identify congenital, delayed and drug-induced deafness, and initiate treatment and follow-up as early as possible.

Objective? To construct the certification evaluation index system for specialized nurse in operating room in accord with nursing practice in China, so as to provide a reference for administrative department to formulate the standards. Methods? From November 2017 to February 2018, we established the certification evaluation index and standard for specialized nurse in operating room by literature review, expert interview and Delphi method, and we tested the reliability of expert enquiry by the concentration degree of expert opinion, coordination coefficient, active coefficient and authority coefficient. The analytic hierarchy process was used to determine the indexes and weight of evaluation standards. Results? A total of 22 experts participated in the study. Among two rounds of enquiries, the active coefficients were 86.67% and 84.62% respectively, and authority coefficients were 0.89 and 0.93 respectively. In the second enquiry, the coordination coefficient was 0.215. The certification evaluation index system for specialized nurse in operating room consisted of 8 primary indexes, 28 secondary indexes and 76 evaluation criteria. The weight of primary indexes, secondary indexes and valuation criteria ranged from 0.031 4 to 0.275 8,from 0.002 0 to 0.206 9 and from 0.000 7 to 0.137 9 respectively. CI values of comparison matrix were from 0 to 0.0480 and CR values were from 0 to 0.053 3. Conclusions? The certification evaluation index system for specialized nurse in operating room is reliable, which can be a reference standard for certification evaluation for specialized nurse in operating room.

Objective: To investigate the influencing factors of sulfated modification of Bupleurum chinense polysaccharides (BCP),and to elucidate the possible mechanism of improving the antioxidant ability of sulfated BCP (S-BCP).Methods:BCP was sulfated by chlorosulfonic acid-pyridine method.The degree of substitution (DS)of S-BCP was observed by adjusting the volume ratios of chlorosulfonic acid to pyridine (1:2,1:4,and 1:8).The structures of BCP and S-BCP were analyzed by infrared (IR)spectroscopy,the morphology of BCP and S-BCP were observed under scanning electron microscopy (SEM).The antioxidant model was established by using 1, 1-diphenyl-2-picrylhydrazyl (DPPH)free radical scavenging.The experiment was divided into positive control group,BCP group and S-BCP group,and the scavenging rates of DPPH free radical in various groups were compared. Results:When the volume ratio of chlorosulfonic acid to pyridine was 1 : 4,the reaction time was 2 h and the reaction temperature was 60 ℃,the maximum sulfur content percentage of S-BCP was 18.62% and the DS was the highest (DS = 2.32 ).Compared with BCP group, the scavenging rate of DPPH free radical of S-BCP was significantly increased (P <0.05).Conclusion:The volume ratio of chlorosulfonic acid to pyridine can affect the DS of S-BCP.The sulfated modification can increase the anti-oxidant capacity of BCP by changing its physic-chemical characters and spatial conformation.

Objective To analyze the related factors and nursing of radiation dermatitis.Methods A total of 100 radiation dermatitis patients treated by radiotherapy were as observation group given nursing intervention.At the same time, another 100 patients with radiation therapy in our hospital without concurrent radiation dermatitis were as control group, clinical basic information and related factors of radiation dermatitis were compared, and degree of radiation dermatitis and the degree of pain before and after treatment in the observation group were observed.Results There was a significant difference between the two groups in hypertension, diabetes mellitus and body mass index and tumor stage (P<0.05).Logistic multivariate regression analysis showed that diabetes mellitus, obesity and the use of compensatory membrane were independent risk factors for the development of radiation dermatitis by tumor radiotherapy (P<0.05).The degree of radiation dermatitis in observation group was significantly lower than nursing before, VAS score was (2.1±0.4) points, which was lower than (4.7±1.5) points than treatment before, the differences were statistically significant (P<0.05).Conclusion Obesity, combined with hypertension, the use of compensation film are risk factors of radiation dermatitis, and nursing intervention measures can help relieve pain for patients with dermatitis and reduce the degree of dermatitis, so it is favorable for prognosis.

Objective To investigate the effect of nursing intervention on the scores of selfcare ability scale (ESCA) and the health survey form (SF-36) of patients with permanent colostomy.Methods A total of 90 patients with permanent colostomy were randomly divided into control group (45 cases) and observation group (45 cases),the control group received conventional nursing intervention colostomy,while patients in the observation group used extended nursing intervention,ESCA,SF-36 scores of various dimensions of the two groups were compared.Results Before the intervention,no significant difference was observed in self-care skills and self responsibility,self concept,selfcare knowledge scores in ESCA scale (P ＞ 0.05).After nursing intervention,the observation group and the control group had higher scores of four dimensions in ESCA scale (P ＜ 0.05),and the observation group was significantly higher than the control group,the differences were statistically significant (P ＜ 0.05).Before nursing intervention,physiological function,social function,emotional function,physical function,body pain,mental health,general health,vitality scores in SF-36 scale showed no significant differences (P ＞ 0.05).After nursing intervention,SF-36 scale scores in the observation group and the control group were significantly higher than intervention before (P ＜ 0.05),and SF-36 scale scores in the observation group were significantly higher than control group (P ＜ 0.05).Conclusion Extended nursing intervention can improve self-care ability and quality of life of patients with permanent colostomy.

Objective To analyze the related factors and nursing of radiation dermatitis.Methods A total of 100 radiation dermatitis patients treated by radiotherapy were as observation group given nursing intervention.At the same time, another 100 patients with radiation therapy in our hospital without concurrent radiation dermatitis were as control group, clinical basic information and related factors of radiation dermatitis were compared, and degree of radiation dermatitis and the degree of pain before and after treatment in the observation group were observed.Results There was a significant difference between the two groups in hypertension, diabetes mellitus and body mass index and tumor stage (P<0.05).Logistic multivariate regression analysis showed that diabetes mellitus, obesity and the use of compensatory membrane were independent risk factors for the development of radiation dermatitis by tumor radiotherapy (P<0.05).The degree of radiation dermatitis in observation group was significantly lower than nursing before, VAS score was (2.1±0.4) points, which was lower than (4.7±1.5) points than treatment before, the differences were statistically significant (P<0.05).Conclusion Obesity, combined with hypertension, the use of compensation film are risk factors of radiation dermatitis, and nursing intervention measures can help relieve pain for patients with dermatitis and reduce the degree of dermatitis, so it is favorable for prognosis.