Objective To investigate the morbidity rate,prevalence and influencing factors of schizophrenia among people aged 15 and above in Henan Province.Methods In 2015,a multi-stage stratified random sampling method was adopted,and the revised General Health Questionnaire (GHQ-12) was used as a preliminary screening tool to carry out mental disorder epidemiological investigation in 20 counties of Henan Province.The sampled people were divided into high,medium and low risk groups according to the GHQ-12 scores.The diagnosis of mental disorders was made by attending psychiatrist with DSM-Ⅳ-TR Axis Ⅰ diagnostic clinical interview pattern scale (SCID).The qualitative data were compared by chi-square test,and the influencing factors of schizophrenia were analyzed by Logistic regression analysis.Results A total of 23 846 people were surveyed,including 11 865 (49.76％) men and 11 981 (50.24％) women in which 124 ones were diagnosed with schizophrenia,with the adjusted lifetime prevalence rate of 5.56‰,and time point prevalence of 5.04‰.Of the 124 cases,83 lived in towns and 41 lived in cities,54 were male and 70 were female.The other basic message:level of education:illiterate 26,primary school 39,junior high school 47,high school or technical secondary school 9,junior or regular college 3;marital status:unmarried 31,first marriage 78,remarried 3,divorced 11,widowed 1.Univariate analysis showed statistically significant differences in the prevalence of schizophrenia at different levels of education (x2=33.903,P＜0.01) and marital status (x2=137.143,P＜0.01).Logistic regression analysis showed that urban and rural areas (Wald x2=37.296,P＜0.01),gender (Wald x2=13.131,P＜0.01),education level (Wald x2=48.338,P＜0.01),marital status (Wald x2=54.495,P＜0.01) and family history (Wald x2=107.340,P＜0.01) were the influencing factors of schizophrenia.Conclusion The prevalence rate of schizophrenia in Henan Province is basically consistent with the research results at home and abroad,and the prevention and treatment of schizophrenia should be based on different regions,ages,genders,et al.

Objective To investigate the morbidity rate,prevalence and influencing factors of schizophrenia among people aged 15 and above in Henan Province.Methods In 2015,a multi-stage stratified random sampling method was adopted,and the revised General Health Questionnaire (GHQ-12) was used as a preliminary screening tool to carry out mental disorder epidemiological investigation in 20 counties of Henan Province.The sampled people were divided into high,medium and low risk groups according to the GHQ-12 scores.The diagnosis of mental disorders was made by attending psychiatrist with DSM-Ⅳ-TR Axis Ⅰ diagnostic clinical interview pattern scale (SCID).The qualitative data were compared by chi-square test,and the influencing factors of schizophrenia were analyzed by Logistic regression analysis.Results A total of 23 846 people were surveyed,including 11 865 (49.76％) men and 11 981 (50.24％) women in which 124 ones were diagnosed with schizophrenia,with the adjusted lifetime prevalence rate of 5.56‰,and time point prevalence of 5.04‰.Of the 124 cases,83 lived in towns and 41 lived in cities,54 were male and 70 were female.The other basic message:level of education:illiterate 26,primary school 39,junior high school 47,high school or technical secondary school 9,junior or regular college 3;marital status:unmarried 31,first marriage 78,remarried 3,divorced 11,widowed 1.Univariate analysis showed statistically significant differences in the prevalence of schizophrenia at different levels of education (x2=33.903,P＜0.01) and marital status (x2=137.143,P＜0.01).Logistic regression analysis showed that urban and rural areas (Wald x2=37.296,P＜0.01),gender (Wald x2=13.131,P＜0.01),education level (Wald x2=48.338,P＜0.01),marital status (Wald x2=54.495,P＜0.01) and family history (Wald x2=107.340,P＜0.01) were the influencing factors of schizophrenia.Conclusion The prevalence rate of schizophrenia in Henan Province is basically consistent with the research results at home and abroad,and the prevention and treatment of schizophrenia should be based on different regions,ages,genders,et al.

Objective To evaluate the F-releasing and recharging properties of six dental restorative materials.Methods Disc specimens 10 mm in diameter and 1 mm in thickness were prepared from 6 different dental restorative materials:Fuji Ⅶ [glass ionomer cement(GIC)],Fuji lⅡ LC(light-curing,GIC),Beautifil(giomer),Compoglass F(compomer),Charisma(composite) and Experimental Ⅰ (a fluoride releasing composite),with 10 discs for each material.Specimens were dipped in 5 ml deionized water and Frelease was detected using a fluoride-specific ion electrode every day from 1-7 days and every three days from 8-28 days.On day 28,specimens were exposed to a fluoride foam for 4 min and then dipped in water,then the F-concentration was detected every day for a week.The specimens were exposed to fluoride foam and fluoride release was detected repeatedly for three times.Results All materials presented the highest F release on the first day after dipping and the F-release sharply decreased after 24 h and slowly decreased after 3 days.On the first day,Fuji Ⅶ presented the highest F-release[(99.68± 15.21) μg· cm-2· d-1],followed by Fuji Ⅱ LC[(37.12±1.67) μg·cm-2·d-1],Experimental Ⅰ [(22.93±1.53) μg·cm-2·d-1],Compoglass F[(15.28±0.70) μg· cm-2· d-1],Beautifil[(2.40±0.52) μg· cm-2· d-1] and Charisma[(0.11±0.02) μg· cm-2· d-1].Within 28 days of dipping,both Fuji Ⅶ and Fuji Ⅱ LC released more F-than other materials did(P＜0.05),followed by Compoglass F and Experimental Ⅰ,and Beautifil and Charisma released the least F-(P＜0.01).After Fuptake,all materials released the highest F-on the first day and presented sharply decrease after 24 h and slowly decrease after 2 days.On the first day after F-uptake,Fuji Ⅶ presented the highest F-release (＞40 μg· cm-2· d-1),much more than other materials(P＜0.01),followed by Fuji Ⅱ LC(＞25 μ.g· cm-2· d-1).Beautifil,Compoglass F and Experimental Ⅰ were close in F-release value(15-20 μg·cm-2· d-1),and Charisma showed the lowest F-release.Conclusions Two glass ionomers were shown to have highest capacity in F-release and uptake,followed by compomer and fluoride releasing composite.Composite demonstrated the lowest F-release and uptake and Giomer was comparable to composite in F-release and to compomer and fluoride releasing composite in F-uptake.

Objective To explore the changes of corticotropin releasing factor (CRF) levels secreted by hypothalamus neuron in children with acute brain injury. Methods Fifty-one intracranial-infection children with brain injury and 11 intracranial-noninfection children with brain injury were chosen from pediatric intensive care unit of our hospital. Severities of their brain damage were evaluated by Glasgow score,and CRF level in cerebrospinal fluid (CSF) and serum TNF-α and IL-6 levels were measured by radioimmunoassay. Results There was no significant difference of Glasgow scores between the intracranial infection group and intracranial-noninfection group ( P = 0. 302 6 ), CSF CRF level of intracranial infection group was significantly lower than that of intracranial-noninfection group ( P ＜ 0. 01 ), serum TNF-α and IL-6 levels of intracranial infection group were significantly higher than those of intracranial-noninfection group ( P ＜ 0. 01,P ＜0. 001 ). As comparing to the children with Glasgow score of 6 ～ 7, the levels of CSF CRF and serum TNF-α and IL-6 in children with Glasgow score of 4 ～ 5 were significantly increased ( P ＜ 0. 05, P ＜ 0. 001 ).Conclusion CSF CRF level of the children with acute brain injury is changing, which may be concerned with the secretion of hypothalamus CRF neuron stimulated by TNF-α, IL-6 and hypoxia stress in children with brain injury.

Objective To observe the effect of glycoprotein receptor blockade tirofiban in acute anterior myocardial infarction patients without ST segment resolution after primary percutaneous coronary intervention (PCI). Methods From April 2006 to April 2008, 157 acute anterior myocardial infarction patients without ST segment resolution after PCI were randomly allocated to tirofiban (intravenous bolus 10 fig/kg followed by intravenous infusion of 0. 15 μg·kg-1·min-1 for 48 h, n =80) or equal volume saline (control group, n =77). Baseline characteristics, PCI features and clinical outcomes during hospitalization, left ventricular ejection fractions (LVEF) and major adverse cardiac events (MACE, including death, re-infarction and target vessel revascularization) at 30 and 180 days after discharge were compared between the two groups. Results The baseline clinical characteristics were comparable between the two groups. Compared to control group, the MACE rates and re-infarction rates at 30 days (6. 3% vs. 18. 2% , P < 0.05; 1.3% vs. 9. 1%, P<0.05, respectively) and 180 days (10.0% vs. 23. 4% , P<0.05; 2.5% vs. 10.4% , P < 0. 05, respectively ) were significantly reduced in tirofiban group. LVEF value was significantly higher in tirofiban group at 30 days and 180 days compared with those in control group [ (51 ± 6)% vs. (46±8)%, P<0.05; (57±7)% vs. (50±9)%, P<0.05]. Hemorrhagic complications were similar between the two groups. Conclusion Use of tirofiban for acute anterior myocardial infarction patients without ST segment resolution after PCI is safe and can significantly improve 30 and 180 days clinical outcomes after discharge.

Objective:To study the immunologic and endocrinologic mechanism of Chinese herbs in the treatment of abortion Methods:SD rats injected with bromocriptine 0 125 mg/d subcutaneously(sc)during day 6~8 of pregnancy were used as aborting model Uteruses of the rats treated with or without Chinese herbs were taken out at day 12 of pregnancy for counting embryoes and determining mRNA levels of Th1/Th2 type cytokines in decidua by semiquantity RT PCR Results:The insufficiency of PRL and P in serum during gestation was related to embryo miscarriage remarkably A predominant Th1 response at the maternal fetal interface is harmful to pregnancy Aborting rate induced by bromocriptine was decreased after treating with Chinese herbs Chinese herbs can increase serum PRL and P , then trigger a predominant Th2 response in the model Conclusion:With it's effect of increasing PRL and P in serum and the Th2 bias response at the maternal fetal interface, Chinese herbs can reverse the abortion effect of bromocriptine