The standardized management of medical insurance settlement list is very important to ensure the rational use of medical insurance funds. In March 2024, this study summarized the problems in the design, implementation, and promotion of the medical insurance settlement list based on expert interviews on the management of the medical insurance fund settlement list, as well as on-site investigations of 46 designated medical institutions in a province. These issues included incomplete design of reporting items that do not fully meet actual needs, inconsistent data collection formats, unclear main responsibilities and workflow of designated medical institutions, inconsistent reporting and information interface standards across regions, limited functionality of medical insurance settlement lists, lack of unified pre verification rules, and incomplete supporting systems. In response to these issues, this study proposed to strengthen the standardization and design of the medical insurance settlement list, clarify the main responsibilities and expand the functions of the list, add pre quality control rules, and improve supporting systems, so as to provide references for promoting the standardized management of medical insurance settlement lists in medical institutions of China.

The standardized management of medical insurance settlement list is very important to ensure the rational use of medical insurance funds. In March 2024, this study summarized the problems in the design, implementation, and promotion of the medical insurance settlement list based on expert interviews on the management of the medical insurance fund settlement list, as well as on-site investigations of 46 designated medical institutions in a province. These issues included incomplete design of reporting items that do not fully meet actual needs, inconsistent data collection formats, unclear main responsibilities and workflow of designated medical institutions, inconsistent reporting and information interface standards across regions, limited functionality of medical insurance settlement lists, lack of unified pre verification rules, and incomplete supporting systems. In response to these issues, this study proposed to strengthen the standardization and design of the medical insurance settlement list, clarify the main responsibilities and expand the functions of the list, add pre quality control rules, and improve supporting systems, so as to provide references for promoting the standardized management of medical insurance settlement lists in medical institutions of China.

Objective:To explore the influencing factors of the secondary sex ratio (SSR) of singleton babies born following assisted reproductive technology.Methods:A total of 7020 single babies delivered by assisted reproductive technology at the Reproductive Medicine Center of the First Affiliated Hospital of USTC (Anhui Provincial Hospital) from January 2000 to December 2018 were collected in a retrospective cohort study. The effect of influencing factors, such as maternal age, fertilization method, embryo transfer type and embryo transfer period on the sex of singleton babies were analyzed.Results:Among 7020 babies, 3730 were boys and 3290 were girls. The total SSR was 113∶100. The SSR of in vitro fertilization (IVF) was significantly higher than that of intracytoplasmic sperm injection (ICSI) fertilization (121∶100 vs. 95∶100, P<0.001), while other factors had no significant effect on the SSR of infants born. In the stratified analysis, there was no difference in SSR between IVF and ICSI in the blastocyst embryo transfer group with mother's age 35 years or older ( P<0.05), while the SSR of IVF in the other groups was higher than that of ICSI (<35 years old group: P<0.001; fresh embryo group: P=0.001; frozen-thawed embryo group: P=0.003; cleavage embryo transfer group: P<0.001). Univariate logistic regression analysis showed that the fertilization method in singleton pregnancy had a statistically significant effect on baby SSR ( OR=0.792, 95% CI=0.712-0.881, P<0.001). After removing confounding factors, logistic regression analysis showed that the fertilization method in singleton pregnancy had a statistically significant effect on neonatal SSR (a OR=0.793, 95% CI=0.713-0.883, P<0.001). Conclusion:The fertilization method of assisted reproductive technology can affect the SSR of singleton newborns. The SSR of IVF is significantly higher than that of ICSI and the difference was significant.

Objective:To explore the influencing factors of the secondary sex ratio (SSR) of singleton babies born following assisted reproductive technology.Methods:A total of 7020 single babies delivered by assisted reproductive technology at the Reproductive Medicine Center of the First Affiliated Hospital of USTC (Anhui Provincial Hospital) from January 2000 to December 2018 were collected in a retrospective cohort study. The effect of influencing factors, such as maternal age, fertilization method, embryo transfer type and embryo transfer period on the sex of singleton babies were analyzed.Results:Among 7020 babies, 3730 were boys and 3290 were girls. The total SSR was 113∶100. The SSR of in vitro fertilization (IVF) was significantly higher than that of intracytoplasmic sperm injection (ICSI) fertilization (121∶100 vs. 95∶100, P<0.001), while other factors had no significant effect on the SSR of infants born. In the stratified analysis, there was no difference in SSR between IVF and ICSI in the blastocyst embryo transfer group with mother's age 35 years or older ( P<0.05), while the SSR of IVF in the other groups was higher than that of ICSI (<35 years old group: P<0.001; fresh embryo group: P=0.001; frozen-thawed embryo group: P=0.003; cleavage embryo transfer group: P<0.001). Univariate logistic regression analysis showed that the fertilization method in singleton pregnancy had a statistically significant effect on baby SSR ( OR=0.792, 95% CI=0.712-0.881, P<0.001). After removing confounding factors, logistic regression analysis showed that the fertilization method in singleton pregnancy had a statistically significant effect on neonatal SSR (a OR=0.793, 95% CI=0.713-0.883, P<0.001). Conclusion:The fertilization method of assisted reproductive technology can affect the SSR of singleton newborns. The SSR of IVF is significantly higher than that of ICSI and the difference was significant.

Objective To discuss the curative effect of MOTOmed training system on the muscle force of upper limbs in patients with CSCI paraplegia .Methods 205 patients with CSCI paraplegia were randomly divided into the observation group (n =99) and the control group (n =106).The control group used conventional treatment of acupuncture , physiotherapy and exercise , while the observation group received MOTOmed seat training system in addition .Functional assessment , muscle force assessment and QIF were conducted and compared between two groups before and after intervention .Results After 4 courses of treatment, the score of left and right muscle force was (10.98 ±2.01)and(10.96 ±2.18)in the observation group.After 8 courses of treatment, the score of left and right muscle force was (11.97 ±1.94)and(12.15 ± 1.94).The scores were significantly different from those in the control group (t=2.238,2.106,2.643,2.608, respectively;P<0.05).Before recovery training, there was no statistically significant difference between two groups (P>0.05).But after training, the difference was statistically significant (P<0.01).The total score of QIF was (46.25 ±2.115) in the observation group, better than that in the control group, and the difference was statistically significant (t=1.963,P<0.01).Conclusions MOTOmed training system can increase the muscle force, muscle hypertonia and muscle strength of patients with CSCI paraplegia , so as to improve their quality of life.

Objective To investigate the neuroprotective effects of picrodideⅡ on cerebral ischemic reperfusion injury in rats. Methods Intraluminal thread methods were applied to establish the left middle cerebral artery occlusion reperfusion models (MCAO/R) in rats. PicrodideⅡ (10mg/kg) and salvianic acid A sodium (10mg/kg) were injected from tail vein for treatment. The neurological behavioral function was evaluated with Bederson's test. The cerebral infarction volume was observed with tetrazolium chloride (TTC) staining. The structure of cells was observed with histopathology. The apoptosis positive cells were counted by terminal deoxynucleotidyl transferase midiated dUTP nick end labeling (TUNEL). Results The neurological behavioral malfunction appeared in all rats with MCAO/R. The infarction focus showed in the ischemic hemisphere following cerebral ischemia reperfusion injury. In the picrodideⅡ and salvianic acid A sodium treatment groups, the number of apoptosis positive cells decreased and the cerebral infarction volume reduced, while the neurological behavioral function was significantly improved than those in the model control group (P<0.05). The cerebral infarction volume in the picrodideⅡ group was smaller than that in the salvianic acid A sodium group (P<0.05).Conclusion PicrodideⅡ might reduce cerebral infarction volume and improve the neurological behavioral function through inhibiting the neuronal apoptosis induced by ischemia reperfusion injury.

To meet the need of cultivating high-quality personnnel,enhance the medicalstudents' ability to analyze and solve problems,directing at the problems existed in pharmacology experiment,we have adjusted and reformed the content of the experiment teaching in pharmacology and conducted the survey and research among the students so as to lay a solid fundation to its reasonable implement.

Objective To observe the influence of neuregulin-1?(NRG-1?) on neuronal apoptosis and the expressions of signal transducer and activator of transcription(STAT3) and glial fiberillary acidic protein(GFAP) following cerebral ischemia/reperfusion in rats.Methods The animal models of middle cerebral artery occlusion/reperfusion(MCAO/R) was established by the intralumianl filament method from left external-internal carotid artery in adult healthy male Wistar rats.The rat models were treated by injecting 1.5% NRG-1? 5?l from internal carotid artery.The neuronal apoptosis was detected by DendEnd fluorometric TUNEL assay,and the expressions of STAT3 and GFAP were determined by immunohistochemical and immumofluorescent assays.Results The cerebral ischemia/reperfusion injury could induce neuronal apoptosis and the expressions of STAT3 and GFAP in brain tissue.In control group,the number of neuronal apoptosis increased gradually and the STAT3 and GFAP were expressed highly along ischemia times in the cortex,striatum and hippocampus areas.After treatment with NRG-1?,the number of neuronal apoptosis reduced and the expression level of STAT3 and GFAP increased when compared to those in the control group at different ischemia times and corresponding areas(P