Rumination is a core cognitive symptom of post-traumatic stress disorder(PTSD),which significantly exacerbates difficulties in emotional regulation and impedes symptom recovery.Its occurrence is closely associated with gray matter structural impairments and abnormal white matter connectivity in the prefrontal-limbic system,including the hippocampus,amygdala,and prefrontal cortex.Functional neuroimaging studies indicate that the neural basis of rumination involves hyperactivation of the default mode network and the salience network,coupled with reduced functionality of the executive control network.Neurochemical research suggests that metabolic imbalances in the glutamate/γ-aminobutyric acid system may further contribute to the maintenance and reinforcement of rumination.Systematically elucidating the neural mechanisms of rumination in PTSD patients based on multimodal neuroimaging evidence will facilitate a deeper understanding of its neuropathological mechanisms and help expand future research directions.

Rumination is a core cognitive symptom of post-traumatic stress disorder(PTSD),which significantly exacerbates difficulties in emotional regulation and impedes symptom recovery.Its occurrence is closely associated with gray matter structural impairments and abnormal white matter connectivity in the prefrontal-limbic system,including the hippocampus,amygdala,and prefrontal cortex.Functional neuroimaging studies indicate that the neural basis of rumination involves hyperactivation of the default mode network and the salience network,coupled with reduced functionality of the executive control network.Neurochemical research suggests that metabolic imbalances in the glutamate/γ-aminobutyric acid system may further contribute to the maintenance and reinforcement of rumination.Systematically elucidating the neural mechanisms of rumination in PTSD patients based on multimodal neuroimaging evidence will facilitate a deeper understanding of its neuropathological mechanisms and help expand future research directions.