Objective:To explore the value of contrast enhanced ultrasonography(CEUS) combined with shear wave elastography (SWE) in the diagnosis of urethral stricture.Methods:One hundred and twenty patients with urethral stricture were recruited, and preoperative retrograde urography, common urethral ultrasound, and CEUS were used to measure the length of the stricture site, and SWE was used to detect the elasticity value of the stricture site and its nearby spongiosum. Intraoperative urethral stricture lesion site measurements were performed to confirm the actual lesion location and length during surgery and to compare them with the lengths measured in the preoperative examination;4 months after surgery, SWE was used to detect the stiffness of the surgical site and to assess the surgical efficacy and prognosis.Results:The stenosis length measured by CEUS and intraoperative measurement had no statistical difference: (4.41 ± 1.47) cm vs. (4.37 ± 1.36) cm, t = 0.22, P>0.05. The elastic value in urethra stenosis in SWE was higher than that in normal urethra: (33.1 ± 6.7) kPa vs. (23.3 ± 4.1) kPa, there was statistical difference ( t = 13.67, P<0.05). The elastic value of unobstructed urethra and that of normal urethra after reconstruction had no statistical difference ( t = 0.95, P>0.05). Conclusions:CEUS combined with SWE is a safe, accurate and effective method to evaluate urethral stricture. SWE can be used to measure postoperative outcomes and recurrence.

Objective:To explore the value of contrast enhanced ultrasonography(CEUS) combined with shear wave elastography (SWE) in the diagnosis of urethral stricture.Methods:One hundred and twenty patients with urethral stricture were recruited, and preoperative retrograde urography, common urethral ultrasound, and CEUS were used to measure the length of the stricture site, and SWE was used to detect the elasticity value of the stricture site and its nearby spongiosum. Intraoperative urethral stricture lesion site measurements were performed to confirm the actual lesion location and length during surgery and to compare them with the lengths measured in the preoperative examination;4 months after surgery, SWE was used to detect the stiffness of the surgical site and to assess the surgical efficacy and prognosis.Results:The stenosis length measured by CEUS and intraoperative measurement had no statistical difference: (4.41 ± 1.47) cm vs. (4.37 ± 1.36) cm, t = 0.22, P>0.05. The elastic value in urethra stenosis in SWE was higher than that in normal urethra: (33.1 ± 6.7) kPa vs. (23.3 ± 4.1) kPa, there was statistical difference ( t = 13.67, P<0.05). The elastic value of unobstructed urethra and that of normal urethra after reconstruction had no statistical difference ( t = 0.95, P>0.05). Conclusions:CEUS combined with SWE is a safe, accurate and effective method to evaluate urethral stricture. SWE can be used to measure postoperative outcomes and recurrence.

Objective:To explore the application value of shear wave elastography (SWE) in male anterior urethral stenosis.Methods:A total of 40 male patients with anterior urethral stenosis admitted to the Sixth People′s Hospital Affiliated to Medical College of Shanghai Jiaotong University from September 2022 to March 2023 were collected. SWE examination was performed before operation to measure the elasticity of urethra and surrounding normal tissues, and to evaluate the location and length of urethral stenosis. When the patient underwent urethral repair and reconstruction surgery, the lesion site of urethral stenosis was measured during the operation to confirm the actual location and length of the lesion during the operation, and the lesion site and length of the urethral stenosis were compared with the preoperative SWE assessment. The specimen of urethral lesion excised during the operation was sent for pathological examination to further confirm whether the tissue was pathological scar tissue.Results:The elastic value of urethral stricture in SWE [(32.9±6.2)kPa] was higher than that of normal urethra [(21.5±4.3)kPa], and the difference was statistically significant ( P<0.05). The length of urinary tract stricture measured by preoperative SWE examination [(3.51±1.09)cm] was basically the same as that of urethral stricture measured during operation [(3.51±1.10)cm], with no statistical significance ( P=0.825). The pathological examination proved that the surgically resected tissue was indeed pathological scar tissue, and the pathological results of the site of urethral stenosis determined by the preoperative SWE examination were 100% consistent with those of the postoperative stenosis. Conclusions:SWE can well evaluate the length of male anterior urethral stenosis and the location of the diseased urethra before surgery, and provide accurate guidance for the scope of urethral lesion and pathological scar resection during surgery.

Objective To explore the application value of intratumoral and peritumoral ultrasomics in predicting the expression level of Ki-67 in breast invasive ductal carcinoma.Methods A retrospective study was conducted on 300 patients who underwent breast surgery and were pathologically confirmed to be breast invasive ductal carcinoma,including 169 cases in low expression group(Ki-67<30%)and 131 cases in high expression group(Ki-67≥30%).The largest cross-section of the lesion on the two-dimensional ultrasound images was selected to delineate the region of interest which was automatically expanded outward by 5 mm to obtain the peritumoral area,and the intratumoral and peritumoral ultrasomics features were extracted.The patients were randomly divided into training group(n=210)and validation group(n=90)in a ratio of 7:3.All features were screened through Z-score standardization,t test,Pearson correlation coefficient and least absolute shrinkage and selection operator algorithm to obtain the optimal feature combination.Random forest(RF)model was used to classify the expression level of Ki-67 in breast invasive ductal carcinoma,and 3 models(intratumoral,peritumoral and combined models)were established,whose diagnostic efficacies in predicting the expression level of Ki-67 in breast invasive ductal carcinoma were evaluated using receiver operating characteristic curve.Results The RF model constructed based on the combination of intratumoral and peritumoral ultrasomics features performed better in predicting the Ki-67 expression status in breast cancer,with the AUC values of 0.899(95%CI:0.860-0.939)in training group and 0.832(95%CI:0.746-0.917)in validation group,demonstrating its superior diagnostic efficacy over the intratumoral and peritumoral radiomics alone(P<0.05).Conclusion A RF model constructed based on intratumoral combined with peritumoral ultrasomics features which has good diagnostic performance in predicting the expression level of Ki-67 in breast invasive ducts has the potential to serve as a non-invasive tool,providing useful information for personalized treatment strategy of breast invasive ductal carcinoma.

Objective:To explore the application value of shear wave elastography (SWE) in male anterior urethral stenosis.Methods:A total of 40 male patients with anterior urethral stenosis admitted to the Sixth People′s Hospital Affiliated to Medical College of Shanghai Jiaotong University from September 2022 to March 2023 were collected. SWE examination was performed before operation to measure the elasticity of urethra and surrounding normal tissues, and to evaluate the location and length of urethral stenosis. When the patient underwent urethral repair and reconstruction surgery, the lesion site of urethral stenosis was measured during the operation to confirm the actual location and length of the lesion during the operation, and the lesion site and length of the urethral stenosis were compared with the preoperative SWE assessment. The specimen of urethral lesion excised during the operation was sent for pathological examination to further confirm whether the tissue was pathological scar tissue.Results:The elastic value of urethral stricture in SWE [(32.9±6.2)kPa] was higher than that of normal urethra [(21.5±4.3)kPa], and the difference was statistically significant ( P<0.05). The length of urinary tract stricture measured by preoperative SWE examination [(3.51±1.09)cm] was basically the same as that of urethral stricture measured during operation [(3.51±1.10)cm], with no statistical significance ( P=0.825). The pathological examination proved that the surgically resected tissue was indeed pathological scar tissue, and the pathological results of the site of urethral stenosis determined by the preoperative SWE examination were 100% consistent with those of the postoperative stenosis. Conclusions:SWE can well evaluate the length of male anterior urethral stenosis and the location of the diseased urethra before surgery, and provide accurate guidance for the scope of urethral lesion and pathological scar resection during surgery.