Objective:To compare the differences of chemical components between single decoction and mixed decoction with different compatibility ratio of Inulae Flos- Haematitum medicinal pair. Methods:UPLC method was used to determine the contents of 5-caffeoylquinic acid, chlorogenic acid, 4-dicaffeoylquinic acid, caffeic acid, isoquercitrin, isochlorogenic acid B, 1,5- dicaffeoyl quinic acid, isochlorogenic acid C and the fingerprints of the single decoctions and mixed decoctions of Inulae Flos- Haematitum medicinal pair in four groups of proportions. The "peak area/sample weight" value of each common peak in the fingerprints was calculated, and the SPSS 26.0 was used for independent-sample t-test analysis. Results:There are significant differences in the "peak area/weight" values of peak 1, peak 2, peak 4, peak 6 , peak 9, peak 10, peak 12, peak 13, peak 15 between mixed decoction and single decoction of Inulae Flos - Haematitum medicinal pair with different compatibility ratios ( P<0.05), with statistical significance; when the compatibility ratio of Inulae Flos- Haematitum medicinal pair was 3:1, the difference of fingerprints and index components content between single decoction and combined decoction was the largest. Except for peak 7 and peak 14, the difference of "peak area/sample weight" value of other characteristic peaks was statistically significant ( P<0.05), and the content difference of 8 index components was statistically significant ( P<0.05). Conclusion:There are differences in the chemical components of Inulae Flos - Haematitum medicinal pair for single decoction and mixed decoction.

Objective To design a notched flexible articulation applied to electric stapler and study its turning performance. Methods The notched flexible articulation was designed and modeled. The kinematics and statics models of the articulation were established for simulation calculations. The stress, deflection angle, top displacement and driving force of the articulation with 3 different turning structures were studied under equal and variable stiffness of symmetrical notches by using finite element simulation. An experimental platform for performance test of the turning structure was built to verify the simulation results and the model. Results The theoretical model of the turning structure in bending process was basically consistent with the experimental results. With the optimization of symmetrical notch stiffness, the maximum stress of the articulation with variable stiffness was reduced by 20.64% and 39.20%, respectively. The articulation with variable stiffness required the smallest tensile force during bending, which was 33.41% lower than that of the articulation with equal stiffness, and the tip displacement (30.8 mm) along the bending plane was the smallest. The maximum deflection angle for the articulation with 3 different turning structures all could reach 90°. Conclusions The kinematics and statics models of the articulation can be used for the calculation of its tensile force and position changes. The turning performance of the articulation with variable stiffness using symmetrical notch is better than that with equal stiffness. The notched flexible articulation meets the design requirements and the turning needs of electric stapler.

HPLC-RID and HPIC-CD methods were established for the determination of sucrose octasulfate content in irinotecan hydrochloride liposomes for injection. HPLC-RID: This method was performed on a Kromasil 100-5-NH₂ column (250 mm×4.6 mm, 5 μm) with a mobile phase of 0.8 mol·L^-1 ammonium sulfate buffer (pH 3.5)-acetonitrile (83∶17). The flow rate, column temperature and detector temperature were maintained at 1 mL·min^-1, 30 ℃ and 30 ℃ respectively. HPIC-CD: This method was performed on an anion exchange column Dionex InPac^TM AS11-HC (250 mm×4 mm, 9 μm) with an eluent of 30 mmol·L^-1 sodium hydroxide solution. The flow rate was 1.5 mL·min^-1, the column temperature was 30 ℃ and the detector temperature was 35 ℃. The HPLC-RID method and HPIC-CD method were validated with respects to specificity, limit of detection, limit of quantitation, linearity, precision, accuracy, stability and robustness and met the validation requirements. There were no significant differences between the HPIC-CD and HPLC-RID methods according to T-test analysis, both of which were applicable for the measurement of sucrose octasulfate concentration in irinotecan hydrochloride liposomes for injection. However, the HPLC-CD was better at the following aspects: higher detection sensitivity, simpler sample pretreatment, lower time and money spent, better environmental protection.

Objective To observe the effects of deep saturation diving on urine volume and trace elements in the urine of the divers , so as to provide theoretical evidence for medical support of deep saturation diving operations and health promotion of divers .Methods Four male healthy divers participated in the 480 msw simulated saturation dive .Twenty-four-hour urine samples were collected the day before entrance into the chamber , during their stay daily in the chamber , and the day after they came out of the chamber .The contents of Ba, Co, Cr, Cu, Fe, Mn, Pb, Sr, Zn in the urine samples were determinated with inductively coupled plasma atomic emission spectrometry , and the data obtained were analyzed with LSD variance analysis .Results Urine volumes of the divers at days 4, 7, 8, 10, 17 and 18 in the chamber were significantly higher than those of both day 1 before enterance into the chamber and the day after surfacing out of the chamber .The urine volume at day 15 in the chamber was significantly higher than that of 1 day before enterance into the chamber . In the 24 h urine samples, the excretion of Ba reached peak at days 10 and 11, and urine volumes at days 16, 18, 19 were significantly lower than those at days 1-11.The excretions of Cr and Co at days 16, 18 and 19 were significantly lower than those at days 1-11.The peak excretions of Fe and Mn all appeared at days 10 and 11, and the peak excretion of Pb was at days 8 and 10.However, the peak excretion of Sr was relatively stable, reaching the peak at day 12.The peak excretion of Zn was at day 8, then decreased gradually and finally reached the bottom at day 19.The peak excretion of Cu at day 10 increased sharply , then decreased gradually and reached bottom at day 19.Conclusions Deep saturation diving exerted certain effects on the urine volume and the metabolism of trace elements in urine in divers .Further research efforts should be made in this respect, so as to provide better medical support and promote the health of divers in special diving operations .

Objective To observe the effects of deep saturation diving on urine volume and trace elements in the urine of the divers , so as to provide theoretical evidence for medical support of deep saturation diving operations and health promotion of divers .Methods Four male healthy divers participated in the 480 msw simulated saturation dive .Twenty-four-hour urine samples were collected the day before entrance into the chamber , during their stay daily in the chamber , and the day after they came out of the chamber .The contents of Ba, Co, Cr, Cu, Fe, Mn, Pb, Sr, Zn in the urine samples were determinated with inductively coupled plasma atomic emission spectrometry , and the data obtained were analyzed with LSD variance analysis .Results Urine volumes of the divers at days 4, 7, 8, 10, 17 and 18 in the chamber were significantly higher than those of both day 1 before enterance into the chamber and the day after surfacing out of the chamber .The urine volume at day 15 in the chamber was significantly higher than that of 1 day before enterance into the chamber . In the 24 h urine samples, the excretion of Ba reached peak at days 10 and 11, and urine volumes at days 16, 18, 19 were significantly lower than those at days 1-11.The excretions of Cr and Co at days 16, 18 and 19 were significantly lower than those at days 1-11.The peak excretions of Fe and Mn all appeared at days 10 and 11, and the peak excretion of Pb was at days 8 and 10.However, the peak excretion of Sr was relatively stable, reaching the peak at day 12.The peak excretion of Zn was at day 8, then decreased gradually and finally reached the bottom at day 19.The peak excretion of Cu at day 10 increased sharply , then decreased gradually and reached bottom at day 19.Conclusions Deep saturation diving exerted certain effects on the urine volume and the metabolism of trace elements in urine in divers .Further research efforts should be made in this respect, so as to provide better medical support and promote the health of divers in special diving operations .