Objective To analyze the efficacy of three-cavity clearance,simple incision and drainage and incision thread drawing procedure in the treatment of patients with perianal abscess and its influence on postoperative pain,wound healing and anal function recovery.Methods 100 patients with perianal abscess in our hospital were included from June 2020 to June 2023.According to different surgical methods,they were divided into group A(n=34,three-cavity clearance),group B(n=33,simple incision and drainage)and group C(n=33,incision thread drawing procedure).The therapeutic effect and postoperative wound healing of the three groups were compared(completely shedding of carrion and wound healing).The pain status[visual analogue pain scale(VAS)]and anal function(Wexner Anal incontinence Scale score)of the 3 groups were compared at 1,7 and 14 days after surgery.The total incidence of complications(infection,anal fistula and anal deformity)in the 3 groups were compared at 14 days after surgery.Results The total therapeutic efficacy rate in group A(94.12％)was significantly higher than that in group B(75.76％)and group C(69.70％)(P＜0.05).The complete shedding of carrion and wound healing time with(15.41±2.07)d,(20.97±2.33)d in group A were significantly shorter than(17.29±2.13)d,(22.65±2.64)d in group B and(18.54±2.16)d,(23.99±2.61)d in group C(P＜0.05).At 1,7 and 14 days after surgery,the VAS score and Wexner Incontinence scale score in group A were significantly lower compared with those in group B and group C(P＜0.05).Within 14 days after surgery,the total incidence rate of infection,anal fistula and anal deformity in group A(8.82％)was lower compared to group B(21.21％)and group C(21.21％)(P＞0.05).Conclusion Three-cavity clearance has a significant effect in the treatment of patients with perianal abscess,and it can relieve the postoperative pain,and promote the wound healing and anal function recovery.

Objective To analyze the efficacy of three-cavity clearance,simple incision and drainage and incision thread drawing procedure in the treatment of patients with perianal abscess and its influence on postoperative pain,wound healing and anal function recovery.Methods 100 patients with perianal abscess in our hospital were included from June 2020 to June 2023.According to different surgical methods,they were divided into group A(n=34,three-cavity clearance),group B(n=33,simple incision and drainage)and group C(n=33,incision thread drawing procedure).The therapeutic effect and postoperative wound healing of the three groups were compared(completely shedding of carrion and wound healing).The pain status[visual analogue pain scale(VAS)]and anal function(Wexner Anal incontinence Scale score)of the 3 groups were compared at 1,7 and 14 days after surgery.The total incidence of complications(infection,anal fistula and anal deformity)in the 3 groups were compared at 14 days after surgery.Results The total therapeutic efficacy rate in group A(94.12％)was significantly higher than that in group B(75.76％)and group C(69.70％)(P＜0.05).The complete shedding of carrion and wound healing time with(15.41±2.07)d,(20.97±2.33)d in group A were significantly shorter than(17.29±2.13)d,(22.65±2.64)d in group B and(18.54±2.16)d,(23.99±2.61)d in group C(P＜0.05).At 1,7 and 14 days after surgery,the VAS score and Wexner Incontinence scale score in group A were significantly lower compared with those in group B and group C(P＜0.05).Within 14 days after surgery,the total incidence rate of infection,anal fistula and anal deformity in group A(8.82％)was lower compared to group B(21.21％)and group C(21.21％)(P＞0.05).Conclusion Three-cavity clearance has a significant effect in the treatment of patients with perianal abscess,and it can relieve the postoperative pain,and promote the wound healing and anal function recovery.

Background and purpose:Single drug of docetaxel and pemetrexed as second line treatment is standard treatment of advanced non-small cell lung cancer (NSCLC). Whether combined with platinum can increase the response and survival is still not elucidated. This study was designed to investigate the treatment response, overall survival (OS) and the safety of combined with oxaliplatin or cisplatin regimens as second line in treating NSCLC patients. Methods:Advanced NSCLC inpatients, failure of cisplatin or carboplatin in initial treatment, were divided into three groups at random in 3∶2∶1 rate. Control group:who received docetaxel, 75 mg/m2 (for all patients), d1 or pemetrexed 500 mg/m2 (for non-squamous carcinoma);Cisplatin group:who received cisplatin 25 mg/m2, d1-3 and docetaxel/pemetrexed; Oxaliplatin group: who received oxaliplatin 130 mg/m2 d1 and docetaxel/pemetrexed. Every 3 weeks were repeated as one cycle. The side effect was assessed every cycle and treatment efifcacy was investigated every two cycles. Follow-up examination was taken every 3 months after treatment. Results:There were no differences in treatment response, progress free survival (PFS), OS and toxicity among the three groups (P>0.05). Old patients (≥60 years) had a better PFS than that of patients less than 60 years (HR=0.56, 95%CI:0.35-0.90, P=0.015). Patients with performance score 0-1 had a better PFS and OS (HR=1.52, 95%CI:1.01-2.30, P=0.048;HR=1.90, 95%CI:1.17-3.09, P=0.009). Treatment response had relation to PFS and OS (HR=2.93, 95%CI:2.01-4.26, P=0.000;HR=2.03, 95%CI:1.37-3.01, P=0.000). Patients with anemia after treatment tended to have a worse PFS and OS (HR=1.59, 95%CI:0.97-2.61, P=0.066;HR=1.60, 95%CI:0.94-2.75, P=0.085). Patients with thrombocytopenia after therapy had a worse OS (HR=2.97, 95%CI:1.01-8.78, P=0.049). Patients with neural toxicity after chemotherapy tended to have a worse PFS (HR=3.36, 95%CI:0.92-12.25, P=0.066). Patients received post treatment after second line therapy had a better OS (HR=0.36, 95%CI:0.22-0.61, P=0.000). Conclusion:Combined with oxaliplatin or cisplatin as second line treatment can’t improve the response and survival in NSCLC patient. Treatment response and PS are prognostic factors to NSCLC patients’ PFS and OS. Patients with treatment related anemia might have a worse survival. Post therapy after failure to second line chemotherapy can prolong the survival.