Sepsis is a common complication in patients with infection,severe trauma and burns.The inflammatory process mediated by IκB/NF-κB in sepsis is considered a target of new anti-inflammatory drugs.Chinese materia medica intervention in sepsis has the characteristics of multi-component,multi-target and minimal adverse reactions.This article summarized the relevant research on the intervention of Chinese materia medica targeting the IκB/NF-κB signaling pathway in sepsis,and concluded the mechanism of TCM monomers and their extracts,TCM prescriptions and preparations in reducing inflammation and oxidative stress,regulating immunity and protecting important organs from damage in sepsis by targeting the IκB/NF-κB signaling pathway.It could provide references for the treatment of sepsis with Chinese materia medica.

Sepsis is a common complication in patients with infection,severe trauma and burns.The inflammatory process mediated by IκB/NF-κB in sepsis is considered a target of new anti-inflammatory drugs.Chinese materia medica intervention in sepsis has the characteristics of multi-component,multi-target and minimal adverse reactions.This article summarized the relevant research on the intervention of Chinese materia medica targeting the IκB/NF-κB signaling pathway in sepsis,and concluded the mechanism of TCM monomers and their extracts,TCM prescriptions and preparations in reducing inflammation and oxidative stress,regulating immunity and protecting important organs from damage in sepsis by targeting the IκB/NF-κB signaling pathway.It could provide references for the treatment of sepsis with Chinese materia medica.