Objective To investigate therapeutic effects of radio frequency ablation ( RFCA) on dysfunctional uterine bleed-ing ( DUB) and analysis of its adverse reactions.Methods In accordance with different methods of treatment, 2 017 cases of dysfunc-tional uterine bleeding patients confirmed and diagnosed by dilatation and curettage were randomly divided into 3 groups: the RFCA group, the mifepristone group and the control group.The RFCA group (1 937 cases) received radio frequency ablation at a power rate of 30-35 W, the mifepristone group (40 cases) was continually given small doses of mifepristone orally, intravenous infusion and he-mostasis, and the control group (40 cases) received intravenous infusion, hemostasis and highly effective progestogen, as deemed nec-essary.The levels of hemoglobin ( Hgb) , the sizes of wombs and the levels of ovary hormone in the patients of the 3 groups were detec-ted periodically, and they all had medical follow-ups for observation of adverse reactions.Results After treatment, improvement could be seen in menorrhagia and anemia for the RFCA group and mifepristone group, but without statistical differences (P>0.05).In the mifepristone group, the mean levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17-esradiol (E2), progester-one ( P) were decreased in varying degrees following treatment, with Ez and P decreased more prominently, as compared with those be-fore medication (P<0.01), while the mean levels of FSH, LH, E2 and P did not fluctuate markedly for the RFCA group, and no sta-tistical significance could be seen, when comparisons were made between pre-treatment and post-treatment (P>0.05) .Main adverse reactions after treatment in the RFCA group were artificial abortion syndromes (212 cases), vaginal discharge (115 cases) and low fe-ver (83 cases)(<38℃).Main adverse reactions in the mifepristone group 3 months after drug withdrawal were irregular colporrhagia (4 cases) and insignificant changes in menstrual flow (2 cases).After 6 months, there was recurrence in 12 cases, which failed to re-spond to the original treatment, and as a result, other treatment had to be used instead.Conclusion The RFCA group could overcome
the deficiency of mifepristone and was a simpler, safer, more effective and less invasive treatment method.

In order to research into the relationship between atrial natriuretic peptide (ANP), aldosterone (Aldo) and pregnancy-induced hypertension (PIH), as well as normal pregnancy, the plasma concentrations of ANP and Aldo from normal pregnant women. PIH patients and their fetuses were measured by radioimmunoassay. It was found that maternal venous Aldo and ANP were higher in normal pregnant women than those in non-pregnant women. The plasma ANP was higher in PIH patients than that in normal pregnant women while plasma Aldo was lower. The plasma concentration of ANP was higher in the fetuses of PIH patients than that in the normal controls, but Aldo was lower. It is concluded that ANP concentration correlates significantly to the severity of PIH, and may be used for an early diagnosis of PIH.