Objective To investigate the real experience and needs of home enteral nutrition(HEN)support for patients with cancer pain so as to provide references for formulating effective clinical nursing intervention programs.Methods Purposive sampling was used to select the patients with cancer pain under HEN in the Department of Pain of our hospital between January and December 2022.Semi-structured interviews were conducted in the study.Data were analysed and summarised,then the themes were extracted using Colaizzi's 7-step method.Results Three themes were extracted,including positive experiences(pain relief,improved nutritional status,sense of family belonging and increased confidence in self-management)and negative experiences(sleep disturbance,limited activities,worry about adversary reactions and complications,and fear of intubation).Patients also expressed the need for more nutritional knowledge and social support(hope for professional guidance and supports from medical resource and policy).Conclusion Medical providers should enhance the management efficiency of the patients with cancer pain and their family members,pay attention to the psychological assessment and intervention during HEN,and strengthen the diversified supports and nursing follow-up of the patients.Effective interventions should be implemented to solve issues that arise during HEN to ensure a smooth and safe implementation.

Objective To investigate the real experience and needs of home enteral nutrition(HEN)support for patients with cancer pain so as to provide references for formulating effective clinical nursing intervention programs.Methods Purposive sampling was used to select the patients with cancer pain under HEN in the Department of Pain of our hospital between January and December 2022.Semi-structured interviews were conducted in the study.Data were analysed and summarised,then the themes were extracted using Colaizzi's 7-step method.Results Three themes were extracted,including positive experiences(pain relief,improved nutritional status,sense of family belonging and increased confidence in self-management)and negative experiences(sleep disturbance,limited activities,worry about adversary reactions and complications,and fear of intubation).Patients also expressed the need for more nutritional knowledge and social support(hope for professional guidance and supports from medical resource and policy).Conclusion Medical providers should enhance the management efficiency of the patients with cancer pain and their family members,pay attention to the psychological assessment and intervention during HEN,and strengthen the diversified supports and nursing follow-up of the patients.Effective interventions should be implemented to solve issues that arise during HEN to ensure a smooth and safe implementation.

Objective To investigate the value of MRI diffusion-weighted imaging (DWI) technique in endocrine therapy for prostate cancer (PCa) based on PI-RADSv2.1. Methods A retrospective analysis of 57 patients with pathologically confirmed PCa was conducted. All patients underwent multi-parametric MRI (mpMRI) according to PI-RADS v2.1 technical specifications before biopsy and six months after endocrine therapy. The apparent diffusion coefficient (ADC) values were measured in cancer and non-cancer areas before biopsy and six months after endocrine therapy. Patients were grouped based on the mRECIST criteria and PSA level into responders (n=45) and non-responders (n=12). ROC curves were obtained to assess the correlation between changes in ADC values and PSA values before and after endocrine therapy. Results In the responder group, the ADC value of the cancer areas was increased significantly after endocrine therapy (P<0.001). No statistically significant difference of the ADC value of the cancer areas was found in the non-responder group before and six months after endocrine therapy (P=0.714). The ADC change of responders and non-responder groups were (0.411±0.178)×10^-3 mm²/s and (-0.014±0.125)×10^-3 mm²/s, respectively (P<0.001); the ADC ratio were (60.603±30.201)% and (-1.096±13.175)%, respectively (P<0.001). The cutoff value of the ADC change was 0.165 (AUC=0.974; sensitivity, 88.89%; specificity, 100.00%; PPV, 100.00%; NPV, 70.59%). The cutoff value of ADC ratio was 16.827% (AUC=0.980; sensitivity, 91.11%; specificity, 100.00%; PPV, 100.00%; NPV, 75.00%). The ADC values were negatively correlated with serum PSA before and after endocrine therapy. Conclusion The ADC change and ADC ratio may be facilitated to monitor the efficacy of endocrine therapy for PCa. The ADC values were negatively correlated with serum PSA.

Objective To explore the heredity susceptibility of children to Kawasaki disease (KD) through studying expression and genomic density polymorphism of peripheral erythrocyte complement receptor-1 (ECRI). Methods Thirty cases of KD patients and 28 cases of healthy children were included in this study. The rates of red blood cell (RBC)-C3bRR and RBC-ICR were detected by method described elsewhere. The ECR1 activity and genomic density polymorphism were detected by Hind Ⅲ restriction enzyme digestion polymerase chain reaction-restriction fragment length polymorphism. Results Rates of RBCoC3bRR of KD patients during the acute phase was significantly lower than that of the control group (P < 0.01), and remained lower than the control group during the recovering phase (P < 0.05). The rates of RBC-ICR were significantly higher in KD patients than that of the control group (P < 0.05). Frequencies of HL and LL genotypes of KD patients were more than those of the control group (P < 0.01). A significant difference was found in the frequency distribution of ECR1 genotype between the two groups (P < 0.01). L allele frequency in the patient group was higher than that in the control group. Conclusions Depressed RBC immune function in KD patients may be linked to the high frequency of L allele, which implies the genomic density polymorphism of ECR1 play an important role in determining susceptibility to Kawasaki disease. (J Clin Pediatr,2010,28(2):160-163)