Objective:To analyze the influencing factors and improvement paths of the cultivation of full-time doctoral scientific and technological innovation ability in large public hospitals, and propose countermeasures and suggestions.Methods:This studyed conducted a survey and analysis of 122 doctors from Linyi People′s Hospital in Shandong Province, and completed a current situation study based on the analysis results.Results:There was no significant difference between the two groups in gender, age, degree type, professional category, discipline level, Graduate School type, job type and other indicators. There were significant differences between the two groups in scientific research topic selection ability score, project design ability score, data analysis ability score, data interpretation ability score, project approval in recent 5 years, project level, number of SCI journal papers published in recent 5 years, cumulative impact factors of SCI journal papers, and annual number of academic activities ( P<0.05). Conclusions:The hospital can improve the scientific and technological innovation ability of full-time doctors by setting up a special cultivation plan, establishing an interdisciplinary team, optimizing scientific research management services, improving the evaluation and assessment system, and improving welfare protection.

Objective:To evaluate the curative effect of hyperbaric oxygen assisting minimally invasive plate osteosynthesis in treating the middle and distal tibia fracture and its influence on the blood supply.Methods:One hundred cases of patients with tibial fractures from January 2016 to December 2018 admitted to the First Department of Ortho Pedics Forth People′s Hospital of Shenyang were selected and randomly divided into control group ( n=50) and observation group ( n=50). The control group was treated with minimally invasive steel plate osteoplasty, and the observation group was treated with hyperbaric oxygen therapy on the basis of the treatment of the control group for 4 consecutive weeks. The pain intensity scores measured by Visual Analog Scale (VAS), skin blood supply at the fracture site, fracture healing and scabbing, bone density, knee/ankle function were compared between the two groups 1 week, 1 month, and 6 months after surgery. Results:One week after surgery, the differences of VAS, fracture healing scores, and bone density between the groups all showed no statistical significance ( P>0.05). One month after surgery, the VAS score, the score of fracture healing and scabbing, and the bone density of the observation group were significantly better than those of the control group ( P<0.05). In the observation group, the incidence of poor blood supply to the skin at the fracture site was 14.0%, which was significantly lower than that of the control group (32.0%) ( P<0.05). The recovery rate of the function of knee and ankle joints was 58.0%, which was higher than that in the control group (38.0%) ( P<0.05). Six months after surgery, the VAS score of the observation group was significantly decreased, and the bone density in the observation group was significantly increased, compared with those of the control group. All differences were statistically significant ( P<0.05). The blood supply to the skin, the fracture healing and scabbing, and the functional recovery of knee and ankle joints of the observation groups were better than those of the control group, but there were no statistical differences( P>0.05). Conclusion:Hyperbaric oxygen assisting minimally invasive plate osteosynthesis in treating the middle and distal tibia fracture could increase the partial pressure of blood oxygen, accelerate the revascularization at the fracture site, reduce local tissue edema and necrosis, promote bone healing, and reduce postoperative pain, which could be used as an auxiliary treatment for the middle and distal tibial fracture.

Objective:To evaluate the curative effect of hyperbaric oxygen assisting minimally invasive plate osteosynthesis in treating the middle and distal tibia fracture and its influence on the blood supply.Methods:One hundred cases of patients with tibial fractures from January 2016 to December 2018 admitted to the First Department of Ortho Pedics Forth People′s Hospital of Shenyang were selected and randomly divided into control group ( n=50) and observation group ( n=50). The control group was treated with minimally invasive steel plate osteoplasty, and the observation group was treated with hyperbaric oxygen therapy on the basis of the treatment of the control group for 4 consecutive weeks. The pain intensity scores measured by Visual Analog Scale (VAS), skin blood supply at the fracture site, fracture healing and scabbing, bone density, knee/ankle function were compared between the two groups 1 week, 1 month, and 6 months after surgery. Results:One week after surgery, the differences of VAS, fracture healing scores, and bone density between the groups all showed no statistical significance ( P>0.05). One month after surgery, the VAS score, the score of fracture healing and scabbing, and the bone density of the observation group were significantly better than those of the control group ( P<0.05). In the observation group, the incidence of poor blood supply to the skin at the fracture site was 14.0%, which was significantly lower than that of the control group (32.0%) ( P<0.05). The recovery rate of the function of knee and ankle joints was 58.0%, which was higher than that in the control group (38.0%) ( P<0.05). Six months after surgery, the VAS score of the observation group was significantly decreased, and the bone density in the observation group was significantly increased, compared with those of the control group. All differences were statistically significant ( P<0.05). The blood supply to the skin, the fracture healing and scabbing, and the functional recovery of knee and ankle joints of the observation groups were better than those of the control group, but there were no statistical differences( P>0.05). Conclusion:Hyperbaric oxygen assisting minimally invasive plate osteosynthesis in treating the middle and distal tibia fracture could increase the partial pressure of blood oxygen, accelerate the revascularization at the fracture site, reduce local tissue edema and necrosis, promote bone healing, and reduce postoperative pain, which could be used as an auxiliary treatment for the middle and distal tibial fracture.

Objective The aim of this study was to assess the expression of protein products of Hugl-1 (human lethal-giant-lavae 1)in non-small cell lung cancer(NSCLC), to estimate their possible expression and to correlate the results of immunohistochemical analysis with various clinicopathologic parameters. Methods The expression of Hugl-1 gene was detected by immunohistochemical S-P method in 50 cases of NSCLC tissues ,50 para-cancer tissues and 10 cases of lung benign lesion tissues as control. Results (1)The expression level of Hugl-1 gene was found to be significantly lower in NSCLC tissues than in para-cancer tissues and lung benign lesion tissues(P