Successful pregnancy requires a balanced immune environment at the maternal-fetal interface, which not only maintains immune tolerance to ensure fetal development, but also requires a moderate immune response to resist infection. The distribution and dynamic changes of macrophages in decidual tissue suggested that it plays an important role in immune regulation, such as influencing vascular remodeling, regulating trophoblast cell function and immune cell activity. MicroRNA (miRNA) is a class of small non-coding RNA involved in the occurrence and development of diseases, and its functions and mechanisms in tumor have been extensively studied. The regulatory role of miRNA in pregnancy, especially in decidual macrophage polarization, is complex. In this paper, we systematically analyzed the phenotypic distribution of decidual macrophages at the maternal-fetal interface, and suggested that the inhibition of M2 phenotype polarization or abnormal activation of M1 was associated with pregnancy complications. We further discussed the regulation of miRNA transcription in immune responses of macrophages and metabolic regulation of macrophage polarization. It was confirmed that abnormal miRNA expression led to adverse pregnancy. A full understanding of the molecular mechanisms of miRNA in inflammatory response and metabolism of decidual macrophages can provide a new insight to the clinical diagnosis and treatment of adverse pregnancy.

Successful pregnancy requires a balanced immune environment at the maternal-fetal interface, which not only maintains immune tolerance to ensure fetal development, but also requires a moderate immune response to resist infection. The distribution and dynamic changes of macrophages in decidual tissue suggested that it plays an important role in immune regulation, such as influencing vascular remodeling, regulating trophoblast cell function and immune cell activity. MicroRNA (miRNA) is a class of small non-coding RNA involved in the occurrence and development of diseases, and its functions and mechanisms in tumor have been extensively studied. The regulatory role of miRNA in pregnancy, especially in decidual macrophage polarization, is complex. In this paper, we systematically analyzed the phenotypic distribution of decidual macrophages at the maternal-fetal interface, and suggested that the inhibition of M2 phenotype polarization or abnormal activation of M1 was associated with pregnancy complications. We further discussed the regulation of miRNA transcription in immune responses of macrophages and metabolic regulation of macrophage polarization. It was confirmed that abnormal miRNA expression led to adverse pregnancy. A full understanding of the molecular mechanisms of miRNA in inflammatory response and metabolism of decidual macrophages can provide a new insight to the clinical diagnosis and treatment of adverse pregnancy.

Objective To explore the clinical effect of the comprehensive nursing for nasopharyngeal carcinoma patients with oral mucosal reaction caused by radiotherapy.Methods A total of 80 patients with nasopharyngeal carcinoma treated by radiotherapy in our hospital were randomly divided into observation group and control group, with 40 cases in each group.The control group was treated with traditional nursing methods while the observation group were given comprehensive nursing methods, the oral mucosa reaction of two groups were compared.Results Compared with the control group, the state of oral mucosa and the cure speed of stomatitis in observation group were significantly better than that of control group (P<0.05).Anxiety, fear, depression, hostility and somatization were lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion The comprehensive nursing can promote the treatment efficacy of stomatitis and improve the quality of life of patients with oral mucosa reaction by radiotherapy.

Objective To explore the clinical effect of the comprehensive nursing for nasopharyngeal carcinoma patients with oral mucosal reaction caused by radiotherapy.Methods A total of 80 patients with nasopharyngeal carcinoma treated by radiotherapy in our hospital were randomly divided into observation group and control group, with 40 cases in each group.The control group was treated with traditional nursing methods while the observation group were given comprehensive nursing methods, the oral mucosa reaction of two groups were compared.Results Compared with the control group, the state of oral mucosa and the cure speed of stomatitis in observation group were significantly better than that of control group (P<0.05).Anxiety, fear, depression, hostility and somatization were lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion The comprehensive nursing can promote the treatment efficacy of stomatitis and improve the quality of life of patients with oral mucosa reaction by radiotherapy.

Objective The aim of this study was to explore the effects of health education intervention on asthma control level for asthma patients through the survey of general demographic information,asthma clinical characteristics of patients with asthma,the Asthma Control Test (ACT),and pulmonary function examination.Methods 126 asthma patients were selected from the clinic and randomly divided into the health education group and the control group.All the patients were followed up for 3 months.In our study,we would scored them in terms of demographic data,clinical features of asthma,asthma cognitive level,medication compliance and Asthma Control Test (ACT) and pulmonary function examination before and after the health education for all patients respectively,and compared the data of the above parameters obtained before and after the intervention and the data from the health education intervention group and the control group.Results In our study,10 cases were lost to follow-up,and 116 cases completed the study at last.There were 68 patients in the health education intervention group and 48 patients in the control group.The results showed that patients with acute attack times,ACT score,pulmonary function indicators and asthma control situations of the health education intervention group after 6 months’ health education,were significantly improved,and the difference was statistically significant.Otherwise,comparison of the contents above of the control group before and after intervention,it was not statistically significant.Meanwhile,com-pared with the control group,the contents above of the health education intervention group were improved with statistically significant differences.Conclusions The standardized health education can improve the quality of life significantly,decrease the asthmatic symptoms,reduce the times of acute onset,which results in maintenance of asthma control,meanwhile the pulmonary function of patients with asthma will improve,so that more patients can live as normal or nearly normal people.

Objective To study the relationship between lymph node micrometastasis and clinicopathological parameters. Methods Immunohistochemical method was adopted to detect CK19,CK20 and CD44v6 in 509 lymph nodes from 53 cases of gastric cancer, in which, conventional pathological diagnosis showed no lymph node metastasis. Results Micrometastasis was found in 47 lymph nodes (9.2%) of 21cases ( 39.6 %). The incidence of micrometastasis was correlated with the depth of invasion, and the incidence of micrometastasis in PT 3 and PT 4 patients was more than that in PT 1 and PT 2 patients(P

AIM: To investigate p16 gene alterations in gastric carcinoma. METHODS: 36 fresh tumor specimens taken from gastric cancer patients were analyzed for p16 gene deletion and mutation by polymerase chain reaction (PCR) and DNA sequencing. RESULTS: Homozygous deletion of exon 1 and exon 3 was observed in 2 cases and 3 cases of diffuse carcinoma, respectively. The frequency of homozygous deletion was 13.89%. No p16 gene point mutation was detected. CONCLUSION: The deletion of p16 genes may be related to gastric carcinogenesis.