Berberine,an isoquinoline alkaloid,is abundant in plants such as Coptis and Phellodendri.It exhibits a wide range of pharmacological activities and has been effectively applied in the clinical treatment of metabolic diseases,infectious diseases,and inflammation.In recent years,berberine's anti-tumor effects have garnered significant attention.Research has demonstrated that berberine can inhibit tumor progression via multiple pathways,including inducing tumor cell apoptosis,regulating the tumor microbiome,arresting the cell cycle,inhibiting tumor angiogenesis,and enhancing the efficacy of tumor immunotherapy.Additionally,berberine can synergistically increase the sensitivity of chemotherapeutic drugs and reduce drug resistance by modulating key signaling pathways such as PI3K/Akt,MAPK,and NF-κB.The antioxidant and immunomodulatory properties of berberine further expand its potential for anti-tumor applications.Based on the findings from basic and clinical research,this review systematically summarizes the latest advances in berberine's anti-tumor mechanisms and clinical applications.It also discusses the challenges and potential solutions in the clinical translation of berberine for cancer therapy,providing a theoretical basis for its development as a novel anti-tumor drug.

Berberine,an isoquinoline alkaloid,is abundant in plants such as Coptis and Phellodendri.It exhibits a wide range of pharmacological activities and has been effectively applied in the clinical treatment of metabolic diseases,infectious diseases,and inflammation.In recent years,berberine's anti-tumor effects have garnered significant attention.Research has demonstrated that berberine can inhibit tumor progression via multiple pathways,including inducing tumor cell apoptosis,regulating the tumor microbiome,arresting the cell cycle,inhibiting tumor angiogenesis,and enhancing the efficacy of tumor immunotherapy.Additionally,berberine can synergistically increase the sensitivity of chemotherapeutic drugs and reduce drug resistance by modulating key signaling pathways such as PI3K/Akt,MAPK,and NF-κB.The antioxidant and immunomodulatory properties of berberine further expand its potential for anti-tumor applications.Based on the findings from basic and clinical research,this review systematically summarizes the latest advances in berberine's anti-tumor mechanisms and clinical applications.It also discusses the challenges and potential solutions in the clinical translation of berberine for cancer therapy,providing a theoretical basis for its development as a novel anti-tumor drug.

Objective To observe the expression levels of Mig in the patients with chronic hepatitis B .Methods The study pop‐ulation consisted of 88 chronic hepatitis B patients and 53 healthy controls .The ELISA ,RT‐PCR and Western‐blotting were used for analysing the expression levels of Mig in serum ,peripheral blood mononuclear cells and liver tissue of the patients with chronic hepatitis B ,while the immunohistochemistry was applied for analysing the distribution of Mig in liver tissue .Results The expres‐sion of Mig in serum ,peripheral blood mononuclear cells and liver tissue of the chronic hepatitis B patients with HBeAg negative were (247 .03 ± 63 .14)pg/mL ,(0 .95 ± 0 .21) ,(0 .79 ± 0 .23) ,and that in the chronic hepatitis B patients with HBeAg positive were (243 .05 ± 53 .00)pg/mL ,(0 .98 ± 0 .35) ,(0 .74 ± 0 .18) ,which were both significantly higher than those in healthy controls ,the difference was statistically significant(P<0 .05) .Conclusion Increased levels of Mig in the patients with chronic hepatitis B may be related to immune state of patients .

Objective To explore the influence of the health belief model education on the life quality of nurses.Methods 200 nurses were randomly divided into the experimental group and the control group with 100 cases in each,the experimental group received health belief model education while the control group was given no intervention.The life quality of nurses before and after the education was compared.Results The life guality of nurses showed no significant difference between the two groups before the health belief model education,one month after health belief model education,life quality of nurses in the two groups showed significant difference.Conclusions Application of the health belief model education can improve the nurses'quality of life.

AIM: To evaluate the effect of hyaluronate based gel (HAbg) in prevention of pleural thickening and adhesion in patients with tuberculous pleural effusions. METHODS: 52 patients with middle amount of tuberculous thoracic fluid accumulated, fluid bound, and pleura thickened more than 2 mm were divided into two groups at random. The patients of two groups were all given standard treatments with anti tuberculous drugs. HAbg was injected into intra thoracic cavity in treatment group (27 patients), while saline (NS) was introduced into intra thoracic cavity in control group (25 patients). Before and after HAbg injection, thoracic fluid routine and protein quantification were tested respectively. Pulmonary functions were measured after 2 weeks and 3 months of thoracic fluid absorption. RESULTS: Patients treated with HAbg showed significantly thinner pleura, lower proteins and white blood cell count in thoracic fluid, and higher FEV1% and FVC% for their pulmonary function in comparison with the control group. CONCLUSION: Intrathoracic injection of HAbg can prevent pleural thickening and improve the lung function in patients with excess fluid of tuberculous thoracic cavity.

AIM: To investigate the effects and safe of low molecular weight heparins (LMWH) in the treatment of patients with chronic pulmonary heart diseases (CPHD) at hypercoagulability state. METHODS: 65 patients were randomly assigned to treatment group (n=33) and control group (n=32). All patients were given routine treatments. The patients of treatment group were hypodermically injected with 4 100～6 150 U of LMWH per day for 7 days as a course. RESULTS: After 7 days of the treatments, the patients of treatment group showed better curative effect and significantly increase in PaO_2 and AT-III and decrease in PaCO_2 and FIB in comparison with the patients in control group (P