Objective To investigate the predictive value of four thrombotic markers[thrombin-antithrombin complex(TAT),tissue-type plasminogen activator-plasminogen activator inhibitor-1 complex(t-PAIC),plasmin-α2-plasmin inhibitor complex(PIC)and thrombomodulin(TM)]for short-term prognosis of patients with acute leukemia complicated by disseminated intravascular coagu-lation(DIC).Methods A prospective cohort study was conducted.Fifty-two patients with acute leukemia complicated by DIC were selected as study group,and 50 patients with simple acute leuke-mia were selected as control group.The general data and levels of the four thrombotic markers(PIC,TAT,TM,t-PAIC)were compared between the two groups.The Kaplan-Meier(KM)survival curve was plotted to analyze the 28-day prognosis of the patients in the study group.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of the four thrombotic markers for poor short-term prognosis in patients with acute leukemia complicated by DIC.Results The plas-ma levels of TAT,PIC,t-PAIC and TM in the study group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Among the patients in the study group,there were 17 deaths(poor prognosis)and 35 survival cases(good prognosis)at 28 days.The plas-ma levels of TAT,PIC,t-PAIC and TM in patients with poor prognosis were higher than those in pa-tients with good prognosis at admission,and the differences were statistically significant(P＜0.05).The ROC curve showed that the area under the curve(AUC)for TAT,PIC,t-PAIC,and TM in predicting poor short-term prognosis in patients with acute leukemia complicated by DIC alone were 0.775,0.769,0.767,and 0.770,respectively.The AUC for the combined prediction of the four thrombotic markers was 0.939,which was higher than that for each individual marker(Z=1.986,2.014,2.026,2.003;P=0.021,0.010,0.008,0.014).Conclusion The four thrombotic markers(TAT,PIC,t-PAIC,TM)have a high predictive value for the short-term prog-nosis of patients with acute leukemia complicated by DIC.Combined detection can provide a refer-ence basis for clinical prognosis prediction in these patients.