Objective:To analyze the changing trends and influencing factors of the Chronic Obstructive Pulmonary Disease(COPD)burden in China,and provide evidence for adjusting related prevention and control policies.Methods:Utilizing the 2021 Global Burden of Disease(GBD)database,it conducted a comprehensive analysis of COPD prevalence,mortality,and disease burden trends in China through disease burden assessment and Age-Period-Cohort(APC)modeling,alongside projections for future trends.Results:From 1990 to 2021,China's age-standardized COPD disease burden showed a declining trend.APC models revealed significant birth cohort effects on COPD prevalence and mortality.Air pollution and tobacco smoke exposure were identified as primary risk factors for COPD-related deaths and disease burden.Projections indicate that the age-standardized prevalence,mortality,and Disability-Adjusted Life Year(DALY)rates of COPD will continue to decrease over the next five years.Conclusion:While China's COPD disease burden has generally declined,prevention and control remain challenging.Significant population heterogeneity in disease burden necessitates targeted interventions for high-risk groups.Establishing an integrated"prevention-diagnosis-control-treatment-rehabilitation"healthcare system is critical to delivering holistic care for COPD patients.

Objective:To analyze the changing trends and influencing factors of the Chronic Obstructive Pulmonary Disease(COPD)burden in China,and provide evidence for adjusting related prevention and control policies.Methods:Utilizing the 2021 Global Burden of Disease(GBD)database,it conducted a comprehensive analysis of COPD prevalence,mortality,and disease burden trends in China through disease burden assessment and Age-Period-Cohort(APC)modeling,alongside projections for future trends.Results:From 1990 to 2021,China's age-standardized COPD disease burden showed a declining trend.APC models revealed significant birth cohort effects on COPD prevalence and mortality.Air pollution and tobacco smoke exposure were identified as primary risk factors for COPD-related deaths and disease burden.Projections indicate that the age-standardized prevalence,mortality,and Disability-Adjusted Life Year(DALY)rates of COPD will continue to decrease over the next five years.Conclusion:While China's COPD disease burden has generally declined,prevention and control remain challenging.Significant population heterogeneity in disease burden necessitates targeted interventions for high-risk groups.Establishing an integrated"prevention-diagnosis-control-treatment-rehabilitation"healthcare system is critical to delivering holistic care for COPD patients.