BACKGROUND:Traditional assessment methods for knee osteoarthritis rely on clinical symptoms,physical examinations,and imaging findings of patients.However,these methods fail to reflect the dynamic changes in knee joint kinetics and do not comprehensively depict the objective status of the knee joint.The emergence of the 6 degree of freedom gait analysis system provides a more objective and practical dynamic assessment method for the severity of knee osteoarthritis.This system serves as a basis for more precise treatment strategies for different patients,thereby optimizing patient treatment approaches.OBJECTIVE:To review relevant assessment systems for knee osteoarthritis,compare the 6 degree of freedom gait analysis with traditional methods for assessing knee osteoarthritis severity,and explore the application of 6 degree of freedom gait analysis in guiding knee osteoarthritis treatment strategies.METHODS:A computer search was conducted using Google Scholar and PubMed databases for relevant articles published from January 2002 to June 2023.English search terms included"knee osteoarthritis,knee osteoarthritis severity,6DOF gait analysis,evaluation methods,WOMAC,KOOS."Chinese search terms were"knee osteoarthritis,osteoarthritis evaluation system,6 degree of freedom gait analysis."Based on inclusion and exclusion criteria,a total of 65 articles were selected for synthesis and summarization.RESULTS AND CONCLUSION:(1)The 6 degree of freedom gait analysis improves the accuracy of knee osteoarthritis severity assessment.Treatment plans based on this method significantly improved patient prognosis.(2)Current research findings suggest standardizing the integration of 6 degree of freedom gait analysis and traditional assessment methods in clinical practice for an objective and accurate evaluation of knee osteoarthritis.This enables better selection of treatment plansand evaluation of the long-term effectiveness of individualized treatment strategies.

BACKGROUND:Traditional assessment methods for knee osteoarthritis rely on clinical symptoms,physical examinations,and imaging findings of patients.However,these methods fail to reflect the dynamic changes in knee joint kinetics and do not comprehensively depict the objective status of the knee joint.The emergence of the 6 degree of freedom gait analysis system provides a more objective and practical dynamic assessment method for the severity of knee osteoarthritis.This system serves as a basis for more precise treatment strategies for different patients,thereby optimizing patient treatment approaches.OBJECTIVE:To review relevant assessment systems for knee osteoarthritis,compare the 6 degree of freedom gait analysis with traditional methods for assessing knee osteoarthritis severity,and explore the application of 6 degree of freedom gait analysis in guiding knee osteoarthritis treatment strategies.METHODS:A computer search was conducted using Google Scholar and PubMed databases for relevant articles published from January 2002 to June 2023.English search terms included"knee osteoarthritis,knee osteoarthritis severity,6DOF gait analysis,evaluation methods,WOMAC,KOOS."Chinese search terms were"knee osteoarthritis,osteoarthritis evaluation system,6 degree of freedom gait analysis."Based on inclusion and exclusion criteria,a total of 65 articles were selected for synthesis and summarization.RESULTS AND CONCLUSION:(1)The 6 degree of freedom gait analysis improves the accuracy of knee osteoarthritis severity assessment.Treatment plans based on this method significantly improved patient prognosis.(2)Current research findings suggest standardizing the integration of 6 degree of freedom gait analysis and traditional assessment methods in clinical practice for an objective and accurate evaluation of knee osteoarthritis.This enables better selection of treatment plansand evaluation of the long-term effectiveness of individualized treatment strategies.

Objective To analyze the clinical characteristics,pathology,CT characteristics and targeted therapy of primary retroperitoneal leiomyosarcoma treated at our institution during the past 20 years.Methods A retrospective review was performed among 11 patients of this disease.The main performances were hematuria,abdominal mass and abdominal pain.Non-enhanced CT scanning showed soft tissue density in all cases.Tri-phase enhanced scanning showed reinforcement in different degrees.Pathology results showed tissue necrosis.The pathology featured by routine HE and immumohistochemical staining.Results Surgical treatment was performed in all 11 patients.Postoperative pathology showed that median tumor diameter was 14.40cm.Spindle cell,cellular abnormity and mitotic figures could be seen through light microscope.During follow-up,3 cases recurrenced after 2 months,3 years and 5 years respectively.Conclusions Primary retroperitoneal leiomyosarcoma might have a high fatality rate and high recurrence rate.The clinical and CT features are unapparent.Pathology diagnosis is reliable,surgery is necessary to prolong life and cure disease.

Objective To observe the clinical efficacy of Huoxue Bitong Plaster on lumbar osteoarthritis with blood stasis and cold-dampness blocking collaterals syndrome. Methods Totally 120 patients were randomly divided into treatment group (60 cases) and control group (60 cases). Huoxue Bitong Plaster was applied externally in the treatment group, while Goupigao Plaster was used externally in the control group, once a day, for two weeks. The clinical efficacy was evaluated by observing TCM symptom scores, VAS, Oswestry dability index (ODI), and onset time in both groups before and after treatment. Results The total effective rate was 86.67%(52/60) in treatment group, and 85.00% (51/60) in the control group, with no statistical significance (P>0.05). TCM symptom scores of both groups decreased after treatment (P<0.05). For the effect of relieving back pain and morning stiffness, the treatment group was superior to control group (P<0.05). For the effect of relieving waist heaviness, the control group was better than the treatment group (P<0.05). Besides, VAS and ODI of the treatment group were lower than the control group after treatment (P<0.05). The onset time of lightening back pain, morning stiffness in the treatment group was quicker than control group (P<0.05). For waist heaviness, the onset time in control group was quicker than treatment group (P<0.05). Conclusion Huoxue Bitong Plaster has good efficacy for lumbar osteoarthritis with blood stasis and cold-dampness blocking collaterals syndrome.

Objective: To observe the effects of acupuncture on synovial pathology, synovial mast cell degranulation and tryptase expression and to investigate the relationship between the functions of mast cells and effects of acupuncture on early adjuvant arthritis in rats. Methods: Forty-six male Wistar rats were randomly divided into normal control group (n=16), untreated group (n=15) and acupuncture group (n=15). Adjuvant arthritis was induced by injection of 0.1 mL Freund's complete adjuvant in right hind limb footpad. Normal control group and untreated group received no acupuncture treatment, while rats in the acupuncture group were treated with sterilized disposable stainless steel needles inserted perpendicularly as deep as 2 to 3 mm at Xuanzhong (GB39), 6 mm at Shenshu (BL23) and 7 mm at Zusanli (ST36) for eight times (15 min each time) every two days. Setting the modeling day as the 0 day of the experiment, the body weight and paw volume of the rats were measured every three days from the 0 day. In the end, synovial tissues of the right hind ankles were sampled and made into paraffin sections. Then they were firstly stained with hematoxylin-eosin for observing synovial pathology to evaluate the effects of acupuncture on adjuvant arthritis, then stained with toluidine blue for observing the number and degranulation ratio of synovial mast cells and finally detected by immunohistochemical staining method to investigate the expression of tryptase in synovium. Results: Compared with the untreated group, the body weight of rats in the acpuncture group was increased significantly (P<0.05), while the paw volume decreased obviously (P<0.01). Hematoxylin-eosin staining showed that acupuncture significantly inhibited inflammatory cell infiltration, synovial cell hyperplasia, and synovial fibroplasia in synovium of rats with adjuvant arthritis as compared with the untreated group (P<0.05). Toluidine blue staining showed that acupuncture could significantly diminish the numbers of total and degranulated mast cells in rats with adjuvant arthritis (P<0.01), which were significantly higher in the untreated group than in the normal control group (P<0.01). Showing by immunohistochemical staining, the expression of tryptase in synovium in the acupuncture group was decreased as compared with the untreated group (P<0.01). Analyzed by Spearman's bivariate correlation, the number of mast cells and degranulation ratio of mast cells were positively correlated with the pathological scores (r=0.837, P<0.01; r=0.634, P<0.01). Conclusion: Acupuncture can improve pathological condition of inflammatory synovium in rats with early adjuvant arthritis by inhibiting the function of synovial mast cells, which may play an important underlying role in the immunoregulation of acupuncture on adjuvant arthritis.