Objective:To investigate the clinical efficacy of emergency bundle combined with hyperbaric oxygen therapy for patients with carbon monoxide poisoning and to analyze prognostic risk factors.Methods:A total of 116 patients with carbon monoxide poisoning treated in Linyi Central hospital from February 2015 to May 2020 were selected retrospectively and divided into control group and treatment group according to different treatment methods，with 58 cases in each group. The control group was treated with hyperbaric oxygen，and the treatment group was treated with emergency bundle on the basis of the treatment of the control group. The clinical efficacy of the two groups were observed and compared.Results:The total effective rate of the treatment group（93.10%）was significantly higher than that of the control group（77.59%），and the difference was statistically significant（ P<0.05）. There was no significant difference in respiratory rate（RR），arterial partial pressure of oxygen（PaO 2），and blood oxygen saturation（SaO 2）between two groups before treatment（ P > 0.05）. After treatment，the respiratory rate（RR），arterial partial pressure of oxygen（PaO 2），and blood oxygen saturation（SaO 2）were improved in two groups compared with those before treatment，and the treatment group was better than the control group，with statistical significance（ P < 0.05 or P < 0.01）. The coma time（≧24 h），abnormal EEG，hyperbaric oxygen treatment time（≧7 d），abnormal head CT and CO exposure time（≧3 h）in two groups were the main factors affecting the prognosis of CO poisoning（ P < 0.01）. Furthermore，coma time，hyperbaric oxygen treatment time，and abnormal head CT were the risk factors affecting the prognosis of CO poisoning（ P < 0.05 or P < 0.01）. Conclusion:Emergency bundle combined with hyperbaric oxygen therapy has a good clinical effect on patients with carbon monoxide poisoning. It can effectively improve the SaO 2 and PaO 2 of patients. The coma time，hyperbaric oxygen treatment time，and abnormal head CT were the risk factors affecting the prognosis of CO poisoning.

Objective:To investigate the clinical efficacy of emergency bundle combined with hyperbaric oxygen therapy for patients with carbon monoxide poisoning and to analyze prognostic risk factors.Methods:A total of 116 patients with carbon monoxide poisoning treated in Linyi Central hospital from February 2015 to May 2020 were selected retrospectively and divided into control group and treatment group according to different treatment methods，with 58 cases in each group. The control group was treated with hyperbaric oxygen，and the treatment group was treated with emergency bundle on the basis of the treatment of the control group. The clinical efficacy of the two groups were observed and compared.Results:The total effective rate of the treatment group（93.10%）was significantly higher than that of the control group（77.59%），and the difference was statistically significant（ P<0.05）. There was no significant difference in respiratory rate（RR），arterial partial pressure of oxygen（PaO 2），and blood oxygen saturation（SaO 2）between two groups before treatment（ P > 0.05）. After treatment，the respiratory rate（RR），arterial partial pressure of oxygen（PaO 2），and blood oxygen saturation（SaO 2）were improved in two groups compared with those before treatment，and the treatment group was better than the control group，with statistical significance（ P < 0.05 or P < 0.01）. The coma time（≧24 h），abnormal EEG，hyperbaric oxygen treatment time（≧7 d），abnormal head CT and CO exposure time（≧3 h）in two groups were the main factors affecting the prognosis of CO poisoning（ P < 0.01）. Furthermore，coma time，hyperbaric oxygen treatment time，and abnormal head CT were the risk factors affecting the prognosis of CO poisoning（ P < 0.05 or P < 0.01）. Conclusion:Emergency bundle combined with hyperbaric oxygen therapy has a good clinical effect on patients with carbon monoxide poisoning. It can effectively improve the SaO 2 and PaO 2 of patients. The coma time，hyperbaric oxygen treatment time，and abnormal head CT were the risk factors affecting the prognosis of CO poisoning.

OBJECTIVE: To investigate the computed tomography findings, clinicopathological features, genetic characteristics and prognosis of in situ adenocarcinoma (AIS) and minimally invasive adenocarcinoma (MIA) of the lung. METHODS: We retrospectively analyzed the data including computed tomography (CT) images, histopathological findings, Ki-67 immunostaining, and genetic mutations in patients with lung adenocarcinoma undergoing surgery at our hospital between 2014 and 2019. RESULTS: Of the total of 480 patients with lung adenocarcinoma we reviewed, 73 (15.2%) had AIS (=28) or MIA (=45) tumors. The age of the patients with MIA was significantly younger than that of patients with AIS ( < 0.02). CT scans identified pure ground-glass nodules in 46.4% of AIS cases and in 44.4% of MIA cases. Multiple GGOs were more common in MIA than in AIS cases ( < 0.05), and bluured tumor margins was less frequent in AIS cases ( < 0.05). No significant difference was found in EGFR mutations between MIA and AIS cases. A Ki-67 labeling index (LI) value ≥2.8% did not differentiate MIA from AIS. The follow-up time in MIA group was significantly shorter than that in AIS group, but no recurrence or death occurred. CONCLUSIONS Despite similar surgical outcomes and favorable survival outcomes, the patients with AIS and MIA show differences in terms of age, CT findings, EGFR mutations and Ki-67 LI.
Adenocarcinoma of Lung ; diagnostic imaging ; pathology ; ErbB Receptors ; genetics ; Humans ; Ki-67 Antigen ; genetics ; Lung Neoplasms ; diagnostic imaging ; pathology ; Mutation ; Prognosis ; Retrospective Studies ; Tomography, X-Ray Computed

Objective To explore the influence of psychological intervention on the immune function of patients with nasopharyngeal carcinoma. Methods Forty nasopharyngeal carcinoma patients with concomitant radiochemotherapy were divided into intervention group and control group by random digits table method with 20 cases each.Among concomitant radiochemotherapy nasopharyngeal carcinoma patients, intervention group were treated with comprehensive psychological behavior, and control group received only concurrent radiotherapy and chemotherapy. Both groups were investigated by Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS).Natural killer cells activity were measured by flow cytometry. Results There were no significantly difference in score of SDS and SAS between two confirmed groups(P>0.05).After treatment,the score of SDS and SAS in intervention group were(45.26± 3.83), (42.57 ± 3.75) points, which were significantly lower than those of control group (52.68 ± 3.66), (51.16 ± 3.62) points, the difference was statistically significant(t =6.264, 7.370, P<0.05). Meanwhile, natural killer cell activity between two groups showed no significantly difference (P>0.05). However, the activity of natural killer cells in intervention group was 26.96±9.01,which was higher than that of control group 22.84 ± 7.19, there were statistically significant difference between two groups (t=2.120, P<0.05).There was a positive correlation between the value difference of SDS scores,SAS scores and natural killer cell activity between two groups (r=0.238, P=0.006; r=0.527, P=0.003). Conclusions Comprehensive psychological intervention can significantly not only improve the depression and anxiety of nasopharyngeal carcinoma patients,but also enhance the activity of natural killer cells,which help maintain the leukocyte level of patients.

Objective To study the characteristics of skinfold thickness of Han adults in Jiangsu province . Methods The skinfold thicknesses of facial , subscapular , suprailiac , biceps , triceps and calf on 311 urban adults ( 157 males and 154 females) and 421 rural adults ( 213 males and 208 females ) of Han were investigated in Huaian city of Jiangsu province .Results The thickness of skinfold of urban females were thicker than that of urban males .Rural adults were the same .Han adults of Jiangsu showed the most significant differences between urban areas and rural areas .The values of six skinfold thicknesses of Jiangsu urban adults have positive correlation with age .Conclusion Han adults of Jiangsu show the most significant differences between genders .