This paper systematically reviewed the concept of authentication studies on traditional Chinese medicine （TCM） classics and the research achievements of scholars across historical and contemporary periods. We categorized the authentication studies on TCM classics into four types， including work-oriented authentication research， metho-dological studies on authentication， extended authentication research， and single-book authentication. Multiple methods were applied comprehensively， including investigating bibliographic documents of successive dynasties， analyzing the academic contents of medical books， studying the textual characteristics of medical books， examining the cited references in medical books， verifying the biographies of authors， and analyzing the interpolations and accretions in medical books， to distinguish the authenticity of TCM classics. The academic value of authenticity identification of TCM classics is concluded in three aspects，i.e. it serves as an important means to distinguish authenticity from falsehood in TCM classics， an important guarantee for inheriting the essence of TCM literature， and a key to unlocking the academic treasure trove of TCM classics and achieving inheritance-based innovation， which will lay a solid documentary foundation for constructing identification methodologies and standardized systems.

Objective:To explore the feasibility of using low-dose computed tomography(LDCT)with deep learning reconstruction(DLR)on the chest for the screening of lung nodules,and to compare the image quality and detection rate of nodules between LDCT and routine dose CT(RDCT)-DLR.Methods:A total of 104 overweight or obese patients[body mass index(BMI)≥25 kg/m2]who received CT examination on chest due to pulmonary nodule screening from September to December 2023 were included to conduct prospective study.All patients underwent respectively RDCT(120 kV)and LDCT(100 kV)scans,all of the two scans used the modulation of automatic tube current,and adopted deep learning AI algorithm ClearInfinity to conduct reconstruction(RDCT:CI 40%,LDCT:CI 50%).Radiation dose and nodules number of them were recorded.At the T8 vertebral level,CT values(Hounsfield Units,HU)of mediastinal fat and lung parenchyma in the right lower lobe were measured,along with image noise(standard deviation,SD).The signal-to-noise ratio(SNR)and contrast-to-noise ratio(CNR)were subsequently calculated.Two radiologists independently performed subjective evaluations of image quality and pulmonary nodules using a Likert 4-point scale.Paired t-tests or Wilcoxon rank-sum test were employed to compare differences in radiation dose,objective image noise,and subjective scores between LDCT and RDCT.Results:A total of 104 patients were enrolled,including 54 males and 50 females,with a mean age of 52±13 years and a BMI of(27.77±2.64)kg/m2.The effective radiation dose of LDCT demonstrated a statistically significant reduction compared to RDCT(Z=-8.853,P<0.001),with a mean effective radiation dose reduction of 77.86%.The differences in lung CT value,lung noise,fat noise,lung parenchyma SNR,fat SNR and CNR of images between two groups were significant(Z=-3.022,-2.327,-4.785,-2.059,-3.765,-4.013,P<0.05),while there were not significant differences in the comparisons for fat CT value and lung parenchyma SNR(P>0.05).The image contrast,image noise,and subjective score for image quality of lung nodule of LDCT were lower than those of RDCT(t=2.877,2.387,5.096,P<0.05),but all subjective scores of that were>3,which can meet the requirements of clinical diagnosis.In terms of nodule detection,RDCT found out about 418 nodules,while LDCT found out about 421,the false positive rate of LDCT only was 0.72%.Conclusion:In overweight or obese patients,LDCT that combined with DLR algorithm on chest is equivalent to RDCT on image quality and the detection rate of lung nodule,and it significantly reduce radiation exposure on patients at the same time.

"Wu Jian Shi Jia"was from Dai Tianzhang's Guang Wen Yi Lun in the Qing Dynasty.By combing the meaning of the word"Wu Jian Shi Jia"and the relevant theoretical views of physicians in the past dynasties,this article summarized the symptoms and treatment outcomes of"Wu Jian Shi Jia"and the situation of concomitant syndromes.The"Wu Jian"refers to epidemic pathogenic factors complicated by cold,wind,summer-heat,malaria,and dysentery,while the"Shi Jia"includes excess syndromes:complications with phlegm-fluid retention,food stagnation,depression,and blood stasis;deficiency syndromes:complications with spleen deficiency,kidney deficiency,and blood depletion;chronic disorders:complications with hernia,heart-stomach pain,and asthma.Additionally,this research expanded the scope of concomitant syndromes of epidemic diseases to accompanying dampness,dryness,toxicity,yin deficiency,and yang deficiency.The theory of"Wu Jian Shi Jia"holds significant literary and application value,enriching the theoretical framework of modern diagnosis and treatment of epidemic diseases.

OBJECTIVE To explore the willingness to pay （WTP） of Urumqi residents for community pharmacies’ medication guidance services and its influencing factors， so as to provide data support for the optimization of community pharmacy services and the establishment of a fee structure for medication guidance services. METHODS A stratified quota sampling method was employed to select 14 communities in Urumqi City. From April to June 2025， a combined offline and online questionnaire survey was conducted among adult residents in these communities. The contingent valuation method was used to construct three hypothetical scenarios （namely， basic， enhanced and extended services） of medication counselling in community pharmacies to assess residents’ WTP for these services. Binary Logistic regression was employed to analyze the influencing factors of WTP. RESULTS A total of 576 valid questionnaires were obtained. Under the scenarios of basic， enhanced and extended services， 38.54%， 49.65% and 67.19% of the respondents expressed WTP for the services， respectively. Occupational type， type of basic medical insurance， annual income， perception of pharmacists’ profession， and acceptance level of the service were identified as major influencing factors for WTP （P＜0.05）. CONCLUSIONS The willingness of residents in Urumqi to pay for medication counseling services provided by pharmacists in community pharmacies significantly increases with the enrichment of service content. It is recommended to incorporate basic medication counselling services provided by pharmacists in community pharmacies into medical insurance payment， while value-added services should be partially or fully self-paid by residents. Additionally， efforts should be made to strengthen the promotion of the professional and service value of licensed pharmacists， so as to facilitate the high-quality development of pharmaceutical care.

By sorting out the records of Atractylodis Macrocephalae Rhizoma as food and medicine, this article believed that Atractylodis Macrocephalae Rhizoma as the same origin of medicine and food for a long history, the earliest in the Qin and Han Dynasty Shen Nong Ben Cao Jing: "Zhu, bitter and warm, having efficacy for cold, dampness, paralysis of dead muscles, and spasm; antiperspirant, removing heat, digesting food, and be used as decoction bait; taking for a long time, losing weight and prolonging life, and don't be hungry". On the basis of Shen Nong Ben Cao Jing, later doctors continue to conduct long-term clinical observation and compatibility of its medicine and food efficacy, which is widely used in internal, external, gynaecology, pediatrics, skin and other departments, to treat spleen and stomach diseases, epidemic diseases, kidney diseases, etc. At the same time of clinical practice, Atractylodis Macrocephalae Rhizoma is also widely used in the folk for dietary therapy, including decoction bait, ointment, decoction, soup and other edible methods. Therefore, as a medicine and food and health preservation product, Atractylodis Macrocephalae Rhizoma has great development potential in daily health care and disease diagnosis and treatment with the effects of non-toxic, satiety and longevity.

Objective To study the efficacy and safety of antiviral therapy in the patients with normal ALT chronic hepatitis B(CHB).Methods The clinical data of the patients with normal ALT CHB visiting in this hospital from December 2019 to December 2023 were collected.The patients were divided into the low vi-ral load group(HBV DNA＜2×106 IU/mL,n=76)and high viral load group(HBV DNA≥2×106 IU/mL,n=10).ETV,TDF and TAF were adopted to conduct the single drug antivirus therapy.The basic informa-tion,demographic characteristics,HBV DNA levels in initial treatment and after 12,24,36,48 weeks of treat-ment,estimated glomerular filtration rate(eGFR)were collected.The rate of complete virological response(CVR)at each time point conducted the statistics for evaluating the effect.The drug safety was evaluated by the eGFR level in 48 weeks of treatment.Results The CVR rates in 12,24,36 weeks of treatment in the low viral load group were 81.6％,94.7％,100.0％and 100.0％respectively,which in the high viral load group were 40.0％,80.0％,80.0％and 80.0％respectively.There was no significant change in eGFR level(109.41±170.57)mL·min-1·1.73 m-2 at 48 weeks of treatment compared with baseline(108.47±110.83)mL·min-1·1.73 m-2(P＞0.05).The ALT and creatinine levels during the treatment process in all the patients were not increased.There was no case of drug withdrawal and drug change due to the drug side effects.Conclusion The overall efficacy and safety of ETV,TDF and TAF monotherapy are good in CHB pa-tients with a family history of cirrhosis or liver cancer and normal ALT.The patients with high viral load at baseline are less likely to achieve CVR in 48 weeks of treatment.

Objective To study the association between serum soluble growth stimulating expression factor 2(sST2),N-terminal pro-B-type natriuretic peptide(NT-probNP),and echocardiographic parameters with myocardial remodeling in patients with heart failure(HF)after acute myocardial infarction(AMI).Methods A total of 120 patients with HF after AMI admitted to the hospital from January 2023 to January 2024 were enrolled.According to the results of echocardiography during a 6-month follow-up,the enrolled patients were divided into a myocardial remodeling group and a non-myocardial remodeling group.Serum sST2,NT-proBNP and echocardio-graphic parameters were compared between groups,and the predictive value on myocardial remodeling was analyzed.Results According to the Killip heart failure classification,the patients were classified into three groups.The sST2,NT-proBNP,left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)and left atrial diameter(LAD)showed progressive increase in the three groups,Killip Ⅱ to Killip Ⅳ(P<0.05).Conversely,left ventricular ejection fraction(LVEF)decreased across the three groups(P<0.05).Multivariate analysis found that high sST2,high NT-proBNP and high LAD were independent risk factors of myocardial remodeling in patients with HF after AMI(P<0.05).ROC curve revealed that the area under the curve(AUC)of the nomogram model was 0.82(95%CI:0.71～0.92).Hosmer-Lemeshow goodness of fit test of the model indicated that the chi-square value was 3.67(χ2=3.67,P=0.801),and it was considered that basic consistency was exhibited between the fitted probability value and actual probability value.After 1 000 times of Bootstrap repeated sampling,the calibration curve was drawn and found that the calibration curve had good consistency with the actual curve,and both were close to the ideal curve.Decision curve displayed that the net benefit of patients was higher than that of the other two extreme curves,and when the threshold probability was between 0.16 and 0.94,the model could produce better clinical benefits.Conclusion The nomogram prediction model based on serum sST2,NT-proBNP and echo-cardiographic parameters has high predictive value on myocardial remodeling in HF patients after AMI.

Objective:To evaluate the efficacy and safety of treatments in phase Ⅰ oncology clinical trials in patients with advanced non-small-cell lung cancer(NSCLC).Methods:We retrospectively analyzed the clinical data of 65 patients with advanced NSCLC who received phase Ⅰ antitumor trial drugs at the Clinical Trial Research Center of The First Affiliated Hospital of Bengbu Medical University from January 2020 to December 2023.The efficacy and occurrence of serious adverse events(SAEs)were analyzed.Results:The objective response rate(ORR)and disease control rate(DCR)were 9.2%and 61.4%,respectively,whereas the median progression-free survival(PFS)and overall survival(OS)were 2.9 and 15.1 months,respectively.Previously receiving second-line or more lines of treatment and SAE occurrence were independent risk factors for a shorter PFS(P<0.05).A history of smoking and previous second-line or more lines of treatment were inde-pendent risk factors for a shorter OS(P<0.05).The SAE incidence was 15.4%,and no treatment-related deaths occurred.Conclusions:Treat-ments in phase Ⅰ oncology clinical trials are beneficial for patients with advanced NSCLC.Patients with a higher number of previous treat-ment lines and those who experienced SAEs during the trial had a shorter PFS,whereas patients with no smoking history and fewer previous treatment lines had a longer overall survival.The overall safety of the treatments was acceptable.

Radiotherapy is one of the primary treatment modalities for tumors. In recent years, advancements in radiotherapy technology have enabled radiation to reach target areas with greater precision. However, radiation damage to normal tissue remains unavoidable. Traditional normal tissue complication probability (NTCP) models are widely used to predict such injuries, but they often fail to account for individual and tissue heterogeneity. As an emerging technology, radiomics can provide more comprehensive biological information and shows promise in predicting radiation-induced damage. This article reviews the application value of radiomics in predicting damage to organs at risk in the head and neck, thorax, abdomen, and pelvis.