1.Effects of Different Obstacle-Crossing Strategies on Dynamic Balance Ability
Leqi LI ; Haoran XU ; Ruiqin WANG ; Jinfeng CAO ; Linlin ZHANG ; Jia HAN ; Jie LÜ
Journal of Medical Biomechanics 2025;40(5):1207-1213
Objective To investigate the dynamic balance ability of healthy young adults under different obstacle-crossing strategies,thereby providing a theoretical basis for fall prevention training and public facility design.Methods Twenty healthy young adults participated in the experiment using F-scan plantar pressure analysis insoles.The subjects were required to cross three obstacles with different combinations of height and width.With their dominant foot serving as the leading foot and the non-dominant foot as the trailing foot,the subjects performed both lateral and forward crossing maneuvers,and their plantar pressure data were collected.Results Different crossing strategies significantly affected the adjustment speed of the leading foot's center of pressure in the medial-lateral direction(COP_ML),the area of the 95%confidence circle,ML amplitude,and anterior-posterior(AP)amplitude(P<0.05).These strategies also significantly impacted the trailing foot's COP_ML adjustment speed,the area of the 95%confidence circle,and the range between the maximum and minimum swings(P<0.05).For the leading foot,during lateral and forward crossing,the balance parameter values under different heights and widths were statistically significant(P<0.05),increasing as the height and width increased.For the trailing foot,during forward crossing,the balance parameter values under different heights were statistically significant(P<0.05),increasing with height,while during lateral crossing,the differences in balance parameter values were not statistically significant(P>0.05).Conclusions Healthy young adults demonstrate better balance ability with the leading foot during forward obstacle crossing,which aligns with the movement habits of the dominant foot and daily activity patterns.The trailing foot exhibits a more stable plantar pressure distribution during lateral obstacle crossing,likely due to a larger contact area and more even center of gravity distribution.
2.Effects of Different Obstacle-Crossing Strategies on Dynamic Balance Ability
Leqi LI ; Haoran XU ; Ruiqin WANG ; Jinfeng CAO ; Linlin ZHANG ; Jia HAN ; Jie LÜ
Journal of Medical Biomechanics 2025;40(5):1207-1213
Objective To investigate the dynamic balance ability of healthy young adults under different obstacle-crossing strategies,thereby providing a theoretical basis for fall prevention training and public facility design.Methods Twenty healthy young adults participated in the experiment using F-scan plantar pressure analysis insoles.The subjects were required to cross three obstacles with different combinations of height and width.With their dominant foot serving as the leading foot and the non-dominant foot as the trailing foot,the subjects performed both lateral and forward crossing maneuvers,and their plantar pressure data were collected.Results Different crossing strategies significantly affected the adjustment speed of the leading foot's center of pressure in the medial-lateral direction(COP_ML),the area of the 95%confidence circle,ML amplitude,and anterior-posterior(AP)amplitude(P<0.05).These strategies also significantly impacted the trailing foot's COP_ML adjustment speed,the area of the 95%confidence circle,and the range between the maximum and minimum swings(P<0.05).For the leading foot,during lateral and forward crossing,the balance parameter values under different heights and widths were statistically significant(P<0.05),increasing as the height and width increased.For the trailing foot,during forward crossing,the balance parameter values under different heights were statistically significant(P<0.05),increasing with height,while during lateral crossing,the differences in balance parameter values were not statistically significant(P>0.05).Conclusions Healthy young adults demonstrate better balance ability with the leading foot during forward obstacle crossing,which aligns with the movement habits of the dominant foot and daily activity patterns.The trailing foot exhibits a more stable plantar pressure distribution during lateral obstacle crossing,likely due to a larger contact area and more even center of gravity distribution.
3.Recent progress of organoids and organ-on-a-chip technology in Alzheimer′s disease
Menghan ZHOU ; Peiyuan ZHU ; Leqi CAO ; Wenying SHI ; Fangyuan QIAN
Chinese Journal of Neurology 2024;57(7):789-794
Alzheimer′s disease (AD) is a neurodegenerative disorder. In the past few decades, the exact mechanisms underlying the onset of the disease have remained unclear, and treatment options are still lacking. Due to the inability of two-dimensional cell and animal models to fully simulate the pathogenesis of AD, there have been shortcomings in clinical trials of new drugs. The development of organoids and organ-on-a-chip technologies has improved the dilemma of AD research, providing reliable in vitro research models for studying pathogenic mechanisms and drug screening. This article elaborates on the applications and progress of organoids and organ-on-a-chip in AD modeling, pathogenesis, and drug development, and discusses the current limitations of organoids and organ-on-a-chip and their future perspectives.
4.Research progress of brain organoid technology in microcephaly
Leqi CAO ; Wenying SHI ; Menghan ZHOU ; Peiyuan ZHU ; Xiyu WANG ; Fangyuan QIAN
Chinese Journal of Perinatal Medicine 2024;27(10):871-875
Microcephaly is a common pediatric neurodevelopmental disorder with complex etiology. In recent years, with the development of brain organoid technology, there has been rapid progress in understanding the pathogenesis and treatment strategies of microcephaly using this technology. This article elucidates the advantages of brain organoids over traditional experimental models, reviews the research progress of brain organoid technology in disease modeling and drug screening for various causes of microcephaly, and discusses the limitations and future prospects of brain organoids.

Result Analysis
Print
Save
E-mail