Objective:To investigate the impact of early cleavage on the pregnancy and obstetric outcomes of fresh cycle single cleavage embryo and single blastocyst transfer.Methods:A retrospective study was conducted to analyze 794 patients who underwent single cleavage embryo transfer and 1466 patients who underwent single blastocyst transfer in the reproductive medicine center of our hospital from August 2018 to December 2022 during the fresh cycle treatment of in vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET).The patients were divided into two groups according to whether the transferred embryos underwent normal early cleavage.In the single cleavage embryo transfer,there were 383 cases in the normal early cleavage group(early cleavage group)and 411 cases in the non normal early cleavage group(non-early cleavage group);in the single blastocyst transfer,there were 815 cases in the early cleavage group and 651 cases in the non-early cleavage group.The pregnancy and obstetric outcomes of the early cleavage group and non-early cleavage group were compared in single cleavage embryo transfer and single blastocyst transfer.Results:In the single cleavage embryo transfer,the human chorionic gonadotropin(hCG)positive rate,clinical pregnancy rate,and live birth rate in the early cleavage group were significantly higher than those in the non-early cleavage group(64.0％vs.55.7％,P=0.018;54.6％vs.47.0％,P=0.032;46.7％vs.38.7％,P=0.022).There were no significant differ-ences in biochemical abortion rate,multiple pregnancy rate,abortion rate,early abortion rate,premature delivery rate,low birth weight rate,macrosomia rate,and birth defect rate compared with the non-early cleavage group(P＞0.05);in the single blastocyst transfer,there were no significant differences in pregnancy outcomes and obstetric indicators between the early cleavage group and the non-early cleavage group(P＞0.05).Multivariate Logistic regression analysis showed that after adjusting for confounding factors on pregnancy outcomes,in the single cleavage embryo transfer,the hCG positive rate(aOR 1.54,95％CI 1.12-2.11,P=0.008),clinical preg-nancy rate(aOR 1.49,95％CI 1.09-2.04,P=0.012),and live birth rate(aOR 1.53,95％CI 1.12-2.09,P=0.008)in the early cleavage group were significantly higher than those in the non-early cleavage group;in the sin-gle blastocyst transfer,there were no significant differences for these indicators between the early cleavage group and the non-early cleavage group(P＞0.05).Conclusions:Transplantation of single cleavage embryo with nor-mal early cleavage can significantly improve the clinical pregnancy rate and live birth rate.Early cleavage during single blastocyst transplantation had no significant effect on clinical pregnancy outcome.Early cleavage had no significant effect on the obstetric outcomes of single cleavage embryo and single blastocyst transfer.

Objective:To investigate the epidemiological characteristics and trends of birth defects related to assisted reproductive technology (ART) in Jiangxi Province from 2014 to 2023, and to explore the correlation factors of birth defect occurrence.Methods:A retrospective collection of ART treatment data and follow-up results from January 2014 to December 2023 across 18 reproductive centers in Jiangxi Province was conducted. The trend of birth defects and the rank order of defect types were analyzed. Exact probability methods were used to estimate the 95% confidence intervals ( CI) of the incidence rates, and Poisson regression was applied to identify independent correlation factors. Results:A total of 65 003 ART offspring were included in this study, comprising 2 025 offspring from intrauterine insemination (IUI) and 62 978 from in vitro fertilization and embryo transfer (IVF-ET). The overall incidence of birth defects was 13.46‰ (95% CI: 12.59‰-14.38‰), with 9.38‰ (95% CI: 5.66‰-14.61‰) for IUI and 13.59‰ (95% CI:12.70‰-14.53‰) for IVF-ET. The incidence of birth defects showed a decreasing trend from 2014 to 2023 (17.11‰ to 11.47‰, Ptrend=0.003). The top three birth defect types were circulatory system defects (3.71‰, 95% CI: 3.25‰-4.21‰), musculoskeletal system defects (2.37‰, 95% CI: 2.01‰-2.77‰), and congenital malformations of the face, ears, eyes, and neck (1.23‰, 95% CI: 0.98‰-1.53‰). Univariate analysis indicated that male offspring from IVF-ET had a higher incidence of birth defects than that in female offspring (14.72‰ vs. 12.31‰, P=0.009). Additionally, gestational age, birth weight, fetal number, cause of infertility, and year of delivery were significantly associated with birth defect incidence in IVF-ET offspring ( P<0.001, P<0.001, P<0.001, P=0.025, P=0.037). Multivariate analysis showed that in singleton pregnancies, male offspring, gestational age 32-36 weeks birth weight <1 500 g, and infertility with bilateral factors were independent risk factors for birth defects ( OR=1.21, 95% CI: 1.00-1.47, P=0.046; OR=1.90,95% CI: 1.41-2.56, P<0.001; OR=3.37, 95% CI: 1.33-8.51, P=0.010; OR=1.38, 95% CI: 1.12-1.69, P=0.003), while in multiple pregnancies, male offspring, gestational age <32 weeks, gestational age 32-36 weeks, birth weight <1 500 g, birth weight 1 500-2 499 g, maternal age 25-29 years and maternal age 30-34 years were independent risk factors ( OR=1.25, 95% CI: 1.03-1.52, P=0.023; OR=2.06, 95% CI: 1.35-3.15, P=0.001; OR=1.32,95% CI: 1.05-1.66, P=0.016; OR=1.98,95% CI: 1.19-3.28, P=0.009; OR=2.06,95% CI: 1.64-2.60, P<0.001; OR=2.00, 95% CI: 1.31-3.06, P=0.001; OR=1.90,95% CI: 1.24-2.92, P=0.003). Conclusion:Over the past 10 years, the incidence of birth defects in ART offspring in Jiangxi Province has shown a decreasing trend annually, with circulatory system malformations being the most common. The occurrence of birth defects in IVF offspring is primarily associated with maternal and infant characteristics, such as gender, gestational age, birth weight, number of fetuses, and cause of infertility, independent of ART treatment factors.

Objective:To investigate the epidemiological characteristics and trends of birth defects related to assisted reproductive technology (ART) in Jiangxi Province from 2014 to 2023, and to explore the correlation factors of birth defect occurrence.Methods:A retrospective collection of ART treatment data and follow-up results from January 2014 to December 2023 across 18 reproductive centers in Jiangxi Province was conducted. The trend of birth defects and the rank order of defect types were analyzed. Exact probability methods were used to estimate the 95% confidence intervals ( CI) of the incidence rates, and Poisson regression was applied to identify independent correlation factors. Results:A total of 65 003 ART offspring were included in this study, comprising 2 025 offspring from intrauterine insemination (IUI) and 62 978 from in vitro fertilization and embryo transfer (IVF-ET). The overall incidence of birth defects was 13.46‰ (95% CI: 12.59‰-14.38‰), with 9.38‰ (95% CI: 5.66‰-14.61‰) for IUI and 13.59‰ (95% CI:12.70‰-14.53‰) for IVF-ET. The incidence of birth defects showed a decreasing trend from 2014 to 2023 (17.11‰ to 11.47‰, Ptrend=0.003). The top three birth defect types were circulatory system defects (3.71‰, 95% CI: 3.25‰-4.21‰), musculoskeletal system defects (2.37‰, 95% CI: 2.01‰-2.77‰), and congenital malformations of the face, ears, eyes, and neck (1.23‰, 95% CI: 0.98‰-1.53‰). Univariate analysis indicated that male offspring from IVF-ET had a higher incidence of birth defects than that in female offspring (14.72‰ vs. 12.31‰, P=0.009). Additionally, gestational age, birth weight, fetal number, cause of infertility, and year of delivery were significantly associated with birth defect incidence in IVF-ET offspring ( P<0.001, P<0.001, P<0.001, P=0.025, P=0.037). Multivariate analysis showed that in singleton pregnancies, male offspring, gestational age 32-36 weeks birth weight <1 500 g, and infertility with bilateral factors were independent risk factors for birth defects ( OR=1.21, 95% CI: 1.00-1.47, P=0.046; OR=1.90,95% CI: 1.41-2.56, P<0.001; OR=3.37, 95% CI: 1.33-8.51, P=0.010; OR=1.38, 95% CI: 1.12-1.69, P=0.003), while in multiple pregnancies, male offspring, gestational age <32 weeks, gestational age 32-36 weeks, birth weight <1 500 g, birth weight 1 500-2 499 g, maternal age 25-29 years and maternal age 30-34 years were independent risk factors ( OR=1.25, 95% CI: 1.03-1.52, P=0.023; OR=2.06, 95% CI: 1.35-3.15, P=0.001; OR=1.32,95% CI: 1.05-1.66, P=0.016; OR=1.98,95% CI: 1.19-3.28, P=0.009; OR=2.06,95% CI: 1.64-2.60, P<0.001; OR=2.00, 95% CI: 1.31-3.06, P=0.001; OR=1.90,95% CI: 1.24-2.92, P=0.003). Conclusion:Over the past 10 years, the incidence of birth defects in ART offspring in Jiangxi Province has shown a decreasing trend annually, with circulatory system malformations being the most common. The occurrence of birth defects in IVF offspring is primarily associated with maternal and infant characteristics, such as gender, gestational age, birth weight, number of fetuses, and cause of infertility, independent of ART treatment factors.

Objective:To investigate the impact of early cleavage on the pregnancy and obstetric outcomes of fresh cycle single cleavage embryo and single blastocyst transfer.Methods:A retrospective study was conducted to analyze 794 patients who underwent single cleavage embryo transfer and 1466 patients who underwent single blastocyst transfer in the reproductive medicine center of our hospital from August 2018 to December 2022 during the fresh cycle treatment of in vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET).The patients were divided into two groups according to whether the transferred embryos underwent normal early cleavage.In the single cleavage embryo transfer,there were 383 cases in the normal early cleavage group(early cleavage group)and 411 cases in the non normal early cleavage group(non-early cleavage group);in the single blastocyst transfer,there were 815 cases in the early cleavage group and 651 cases in the non-early cleavage group.The pregnancy and obstetric outcomes of the early cleavage group and non-early cleavage group were compared in single cleavage embryo transfer and single blastocyst transfer.Results:In the single cleavage embryo transfer,the human chorionic gonadotropin(hCG)positive rate,clinical pregnancy rate,and live birth rate in the early cleavage group were significantly higher than those in the non-early cleavage group(64.0％vs.55.7％,P=0.018;54.6％vs.47.0％,P=0.032;46.7％vs.38.7％,P=0.022).There were no significant differ-ences in biochemical abortion rate,multiple pregnancy rate,abortion rate,early abortion rate,premature delivery rate,low birth weight rate,macrosomia rate,and birth defect rate compared with the non-early cleavage group(P＞0.05);in the single blastocyst transfer,there were no significant differences in pregnancy outcomes and obstetric indicators between the early cleavage group and the non-early cleavage group(P＞0.05).Multivariate Logistic regression analysis showed that after adjusting for confounding factors on pregnancy outcomes,in the single cleavage embryo transfer,the hCG positive rate(aOR 1.54,95％CI 1.12-2.11,P=0.008),clinical preg-nancy rate(aOR 1.49,95％CI 1.09-2.04,P=0.012),and live birth rate(aOR 1.53,95％CI 1.12-2.09,P=0.008)in the early cleavage group were significantly higher than those in the non-early cleavage group;in the sin-gle blastocyst transfer,there were no significant differences for these indicators between the early cleavage group and the non-early cleavage group(P＞0.05).Conclusions:Transplantation of single cleavage embryo with nor-mal early cleavage can significantly improve the clinical pregnancy rate and live birth rate.Early cleavage during single blastocyst transplantation had no significant effect on clinical pregnancy outcome.Early cleavage had no significant effect on the obstetric outcomes of single cleavage embryo and single blastocyst transfer.

Objective:To evaluate the effect of Kuntai capsules combined with progestin-primed ovarian stimulation (PPOS) protocol on the ovarian response, laboratory parameters and embryo transfer outcomes of expected poor ovarian response (POR) patients undergoing invitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. Methods:A retrospective cohort study was performed at Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital from June 2020 to July 2023. A total of 1 733 expected POR patients were enrolled and divided into the PPOS only group (control group) and the Kuntai capsules combined with PPOS regimen group (trial group). After a 1∶1 propensity score matching, 423 cases were included in each group. Further analyses and comparisons were made between the two groups, concerning the ovarian stimulation outcomes, embryo laboratory parameters and pregnancy rates after the first frozen-thawed embryo transfer cycles. The primary outcome measure was the number of oocytes retrieved.Results:No statistically significant difference was found in baseline characteristics after matching between the two groups (all P>0.05). Compared with control group, the number of oocytes retrieved did not differ significantly in the trial group ( P=0.295). The level of luteinizing hormone (LH) on the trigger day [3.3 (2.2, 5.0) U/L], the number of available blastocysts formed [1 (0, 1)] and the available blastocyst formation rate [46.2% (85/184)] in the trial group were significantly higher than those in control group [2.9 (1.9, 4.5) U/L, P=0.004; 0 (0, 1), P=0.034; 30.0% (48/160), P=0.002]. However, there were no significant differences in the duration and dosage of gonadotropin used, progesterone and estradiol levels on the trigger day, incidence of premature LH surge, number/rate of fertilized oocytes, number/rate of cleaved embryos, number/rate of high-quality embryos, as well as rate of unavailable embryos (all P>0.05). Compared with control group, the trial group demonstrated comparable implantation rate, clinical pregnancy rate, early miscarriage rate, ongoing pregnancy rate and live birth rate after the first frozen-thawed embryo transfer cycles (all P>0.05). Conclusion:Compared with the PPOS only regimen, the combination of Kuntai capsules and PPOS did not increase the number of oocytes retrieved but could increase the number and rate of available blastocysts formed in expected POR patients.

Objective:To evaluate the effect of Kuntai capsules combined with progestin-primed ovarian stimulation (PPOS) protocol on the ovarian response, laboratory parameters and embryo transfer outcomes of expected poor ovarian response (POR) patients undergoing invitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. Methods:A retrospective cohort study was performed at Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital from June 2020 to July 2023. A total of 1 733 expected POR patients were enrolled and divided into the PPOS only group (control group) and the Kuntai capsules combined with PPOS regimen group (trial group). After a 1∶1 propensity score matching, 423 cases were included in each group. Further analyses and comparisons were made between the two groups, concerning the ovarian stimulation outcomes, embryo laboratory parameters and pregnancy rates after the first frozen-thawed embryo transfer cycles. The primary outcome measure was the number of oocytes retrieved.Results:No statistically significant difference was found in baseline characteristics after matching between the two groups (all P>0.05). Compared with control group, the number of oocytes retrieved did not differ significantly in the trial group ( P=0.295). The level of luteinizing hormone (LH) on the trigger day [3.3 (2.2, 5.0) U/L], the number of available blastocysts formed [1 (0, 1)] and the available blastocyst formation rate [46.2% (85/184)] in the trial group were significantly higher than those in control group [2.9 (1.9, 4.5) U/L, P=0.004; 0 (0, 1), P=0.034; 30.0% (48/160), P=0.002]. However, there were no significant differences in the duration and dosage of gonadotropin used, progesterone and estradiol levels on the trigger day, incidence of premature LH surge, number/rate of fertilized oocytes, number/rate of cleaved embryos, number/rate of high-quality embryos, as well as rate of unavailable embryos (all P>0.05). Compared with control group, the trial group demonstrated comparable implantation rate, clinical pregnancy rate, early miscarriage rate, ongoing pregnancy rate and live birth rate after the first frozen-thawed embryo transfer cycles (all P>0.05). Conclusion:Compared with the PPOS only regimen, the combination of Kuntai capsules and PPOS did not increase the number of oocytes retrieved but could increase the number and rate of available blastocysts formed in expected POR patients.

Objective:To analyze the difference of maternal and neonatal outcomes for the living infant of surgically and spontaneously reduced dichorionic pregnancies following assisted reproductive technology (ART).Methods:We used a retrospective cohort study to analyze the clinical data of 11 050 fresh/frozen-thawed double embryos transfer with singleton live birth cycles in the Center for Reproductive Medicine of Jiangxi Maternal and Child Health Hospital from March 2014 to October 2021, including 226 cases in the surgical reduction group, 1 506 cases in the spontaneous reduction group, and 9 318 cases of singleton pregnancy in control group. The basic clinical data, maternal and fetal complications and birth outcomes of the three groups were compared by univariate analysis. Multivariate logistic regression was used to analyze the factors affecting maternal and infant outcomes.Results:The rate of premature rupture of membranes in the natural fetal reduction group, the surgical reduction group and control group was 1.4% (21/1 506), 1.3% (3/226) and 0.6% (56/9 318), respectively, with a significant difference among the three groups ( P=0.003). The differences of the risk of preterm birth, very premature birth, low birth weight, very low birth weight, and small for gestational age among the surgical fetal reduction group [17.3% (39/226), 4.0% (9/226), 15.5% (35/226), 3.1% (7/226), 9.3% (21/226)], the natural fetal reduction group [11.6% (175/1 506), 1.9% (28/1 506), 8.6% (129/1 506), 1.3% (20/1 506), 9.1% (137/1 506)] and control group [7.7% (721/9 318), 0.9% (86/9 318), 3.9% (367/9 318), 0.5% (45/9 318), 6.0% (560/9 318)] were statistically significant (all P<0.001). Compared with the spontaneous reduction group, the surgical reduction group had a higher risk of premature birth [(a OR=2.37, 95% CI: 1.64-3.42, P<0.001) vs. (a OR=1.54, 95% CI: 1.29-1.84, P<0.001)], very preterm birth [(a OR=4.26, 95% CI: 2.02-8.97, P=0.001) vs. (a OR=1.95, 95% CI: 1.26-3.01, P=0.003)], low birth weight [(a OR=4.35, 95% CI: 2.94-6.44, P<0.001) vs. (a OR=2.26, 95% CI: 1.83-2.79, P<0.001)] and small-for-gestational age[(a OR=1.82, 95% CI: 1.14-2.92, P=0.013) vs. (a OR=1.60, 95% CI: 1.31-1.95, P<0.001)]. There was no statistical difference in birth defect rate among the three groups ( P>0.05). Conclusion:The risk of maternal and fetal complications and birth defects for the living singletons of surgically and spontaneously reduced dichorionic diamniotic pregnancies were similar to those singleton pregnancies following ART, but the proportion of premature rupture of membranes is higher, and the risk of premature birth and low birth weight of surgical reduction were higher than that of spontaneous reduction. Surgical reduction is not recommended to use as a rescue measure of dichorionic twins conceived by ART.

Objective:To analyze the difference of maternal and neonatal outcomes for the living infant of surgically and spontaneously reduced dichorionic pregnancies following assisted reproductive technology (ART).Methods:We used a retrospective cohort study to analyze the clinical data of 11 050 fresh/frozen-thawed double embryos transfer with singleton live birth cycles in the Center for Reproductive Medicine of Jiangxi Maternal and Child Health Hospital from March 2014 to October 2021, including 226 cases in the surgical reduction group, 1 506 cases in the spontaneous reduction group, and 9 318 cases of singleton pregnancy in control group. The basic clinical data, maternal and fetal complications and birth outcomes of the three groups were compared by univariate analysis. Multivariate logistic regression was used to analyze the factors affecting maternal and infant outcomes.Results:The rate of premature rupture of membranes in the natural fetal reduction group, the surgical reduction group and control group was 1.4% (21/1 506), 1.3% (3/226) and 0.6% (56/9 318), respectively, with a significant difference among the three groups ( P=0.003). The differences of the risk of preterm birth, very premature birth, low birth weight, very low birth weight, and small for gestational age among the surgical fetal reduction group [17.3% (39/226), 4.0% (9/226), 15.5% (35/226), 3.1% (7/226), 9.3% (21/226)], the natural fetal reduction group [11.6% (175/1 506), 1.9% (28/1 506), 8.6% (129/1 506), 1.3% (20/1 506), 9.1% (137/1 506)] and control group [7.7% (721/9 318), 0.9% (86/9 318), 3.9% (367/9 318), 0.5% (45/9 318), 6.0% (560/9 318)] were statistically significant (all P<0.001). Compared with the spontaneous reduction group, the surgical reduction group had a higher risk of premature birth [(a OR=2.37, 95% CI: 1.64-3.42, P<0.001) vs. (a OR=1.54, 95% CI: 1.29-1.84, P<0.001)], very preterm birth [(a OR=4.26, 95% CI: 2.02-8.97, P=0.001) vs. (a OR=1.95, 95% CI: 1.26-3.01, P=0.003)], low birth weight [(a OR=4.35, 95% CI: 2.94-6.44, P<0.001) vs. (a OR=2.26, 95% CI: 1.83-2.79, P<0.001)] and small-for-gestational age[(a OR=1.82, 95% CI: 1.14-2.92, P=0.013) vs. (a OR=1.60, 95% CI: 1.31-1.95, P<0.001)]. There was no statistical difference in birth defect rate among the three groups ( P>0.05). Conclusion:The risk of maternal and fetal complications and birth defects for the living singletons of surgically and spontaneously reduced dichorionic diamniotic pregnancies were similar to those singleton pregnancies following ART, but the proportion of premature rupture of membranes is higher, and the risk of premature birth and low birth weight of surgical reduction were higher than that of spontaneous reduction. Surgical reduction is not recommended to use as a rescue measure of dichorionic twins conceived by ART.

Objective:To explore the effect of body mass index (BMI) and body weight on the ovarian responsiveness of patients undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) treatment with early follicular phase long-acting long regimen, and to instruct reproductive doctors to choose the most accurate indicators when formulating individualized starting dosage of gonadotropin (Gn). Methods:A retrospective cohort study analysis of the clinical data of 5762 patients who applied the early follicular phase long-acting long regimen and the Gn starting dosage was 112.5 U during IVF/ICSI-ET treatment at the Assisted Reproductive Center of Jiangxi Maternal and Child Health Hospital from January 2014 to December 2019. Totally 1/5 patients in the middle of BMI (BMI range: 20.70-22.03 kg/m 2) were selected and divided into low weight group (<51 kg), normal weight group (51-56 kg), and high weight group (>56 kg). According to body weight, the ovarian reactivity was analyzed among the three groups. In the same way, 1/5 patients in the middle of weight (weight range: 52 kg to 55 kg) were divided into low BMI group (<20.30 kg/m 2), normal BMI group (20.30-22.19 kg/m 2), high BMI group (>22.19 kg/m 2) and the ovarian reactivity of the three groups was analyzed. Results:There were significant differences in total Gn used dosage [1 612.50(1 350.00, 1 950.00) U vs. 1 687.50(1 387.50, 2 100.00) U vs. 1 793.75(1 443.75, 2 250.00) U], progesterone level [0.89(0.60, 1.19) μg/L vs. 0.78(0.53, 1.05) μg/L vs. 0.69(0.50, 0.92) μg/L] and estradiol level [2 569.00(1 774.00, 3 681.00) ng/L vs. 2 208.50(1 614.00, 3 020.52) ng/L vs. 2 018.00(1 385.00, 2 787.00) ng/L] on the day of human chorionic gonadotropin (hCG) injection, IVF normal fertilization rate [66.36% (1539/2319) vs. 66.46% (5460/8216) vs. 62.86% (1281/2038)] and ICSI normal fertilization rate [74.77% (320/428) vs. 78.31% (1368/1747) vs. 71.34% (224/314)] among the 1/5 patients in the middle of BMI grouped by body weight ( P=0.006, P<0.001, P<0.001, P=0.008, P=0.014). Covariance analysis was used to balance BMI, age and antral follicle count (AFC), and it is found that the number of oocytes retrieved in the three groups was significantly different ( P=0.022). However, for the 1/5 patients in the middle of body weight grouped by BMI, there were significant differences in age [28(26, 31) years vs. 29(27, 32) years vs. 29(27, 32) years], total Gn used dosage [1 725.00(1 368.75,2 100.00) U vs. 1 725.00(1 387.50, 2 100.00) U vs. 1 875.00(1 425.00,2 300.00) U], IVF normal fertilization rate [66.06% (1775/2687) vs. 65.88% (5689/8635) vs. 62.91% (1589/2526)], ICSI normal fertilization rate [74.73% (482/645) vs. 77.93% (1511/1939) vs. 67.97% (418/615)] and the number of available embryos [3.0(2.0,5.0) vs. 3.0(2.0,5.0) vs. 3.0(2.0,4.0)] among the three groups ( P=0.015, P=0.042, P=0.015, P<0.001, P<0.001). The results of covariance analysis showed that there was no difference in the number of oocytes retrieved among the three groups after balancing BMI, age and AFC ( P=0.443). Conclusion:Body weight is more predictive of ovarian responsiveness than BMI. It is recommended that reproductive doctors determine the starting dosage of Gn based on body weight rather than BMI.

Objective:To explore the risk factors of abortion and their interactions in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). Methods:A total of 3556 pregnant women who underwent IVF/ICSI-ET in Jiangxi Maternal and Child Health Hospital from January 2014 to June 2019 were analyzed, among which 889 women were diagnosed with PCOS (PCOS group) and 2667 women were diagnosed with infertility due to simple tube factors (control group). The clinical outcomes after pregnancy were compared between the two groups. Single and multiple logistic regression were used to find the influencing factors of abortion. Finally, subgroup analysis was conducted according to single/twin pregnancy and body mass index (BMI).Results:The abortion rate [11.81% (105/889)] and the late abortion rate [5.29% (47/889)] in PCOS group were significantly higher than those in control group [9.19% (245/2667), P=0.023; 3.64% (97/2667), P=0.031]. Univariate logistic regression showed that PCOS, twin pregnancy, high BMI, long duration of infertility were the risk factors of abortion. Multivariate logistics regression showed that the main risk factors affecting abortion rate were twin pregnancy, PCOS, and the interaction between the two factors. Subgroup analysis found that there were no differences in the early and late abortion rates between the two groups when women were singleton pregnancy. When women were twin pregnancy, the rate of early abortion was similar between the two groups, while the late abortion rate [8.58% (29/338)] in PCOS group was significantly higher than that in control group [3.11% (37/1188), P<0.001]. Conclusion:The rate of abortion is similar for PCOS women and simple tube factor infertility women when they were singleton pregnancy after IVF/ICSI-ET treatment. PCOS women have a similar rate of early abortion and higher rate of late abortion than simple tube factor infertility women when they were twin pregnancy.