Objective To explore the medication patterns as well as the potential mechanism of action of traditional Chinese medicine in the treatment of presbycusis based on data mining and network pharmacology.Methods Search for the literatures on the treatment of presbycusis with traditional Chinese medicine in CNKI,Wanfang Data Knowledge Service Platform and VIP,conduct visual analyses such as association rule analysis and cluster analysis on them,and summarize the medication patterns and core drug combinations.Predict the action targets of drugs and diseases through network pharmacology,and obtain core targets and pathways.Results A total of 22 literatures were included,and 22 traditional Chinese medicine prescriptions were obtained,involving 72 kinds of traditional Chinese medicines,with a total frequency of administration of 238 times.The four natures of the medicine were mainly warm,the five flavors were mainly sweet,bitter and pungent,and channel tropism were mainly liver meridian and kidney meridian.The core drug combination was Shanzhuyu and Shudihuang.Network pharmacological analysis showed that this combination may improve presbycusis by influencing core targets such as protein kinase B(Akt)1 and interleukin-6,thereby intervening in related pathways such as advanced glycation end product/advanced glycation end product receptor signaling pathway and the phosphoinositide 3-kinase/Akt signaling pathway.Conclusion The treatment of presbycusis with traditional Chinese medicine mainly focuses on invigorating kidney for consolidating semen,while also circulate and nourish blood.Network pharmacology predicts the key mechanisms of core high-frequency drug treatment for presbycusis,providing data support and theoretical basis for the clinical treatment of traditional Chinese medicine.

Objective To explore the medication patterns as well as the potential mechanism of action of traditional Chinese medicine in the treatment of presbycusis based on data mining and network pharmacology.Methods Search for the literatures on the treatment of presbycusis with traditional Chinese medicine in CNKI,Wanfang Data Knowledge Service Platform and VIP,conduct visual analyses such as association rule analysis and cluster analysis on them,and summarize the medication patterns and core drug combinations.Predict the action targets of drugs and diseases through network pharmacology,and obtain core targets and pathways.Results A total of 22 literatures were included,and 22 traditional Chinese medicine prescriptions were obtained,involving 72 kinds of traditional Chinese medicines,with a total frequency of administration of 238 times.The four natures of the medicine were mainly warm,the five flavors were mainly sweet,bitter and pungent,and channel tropism were mainly liver meridian and kidney meridian.The core drug combination was Shanzhuyu and Shudihuang.Network pharmacological analysis showed that this combination may improve presbycusis by influencing core targets such as protein kinase B(Akt)1 and interleukin-6,thereby intervening in related pathways such as advanced glycation end product/advanced glycation end product receptor signaling pathway and the phosphoinositide 3-kinase/Akt signaling pathway.Conclusion The treatment of presbycusis with traditional Chinese medicine mainly focuses on invigorating kidney for consolidating semen,while also circulate and nourish blood.Network pharmacology predicts the key mechanisms of core high-frequency drug treatment for presbycusis,providing data support and theoretical basis for the clinical treatment of traditional Chinese medicine.