Objective To investigate the effects of high-frequency repetitive transcranial magnetic stimulation(HF-rTMS)applied to the supplementary motor area(SMA)or primary motor cortex(M1)on upper limb function in stroke patients in terms of motor sequence learning.Methods From April,2024 to February,2025,60 inpatients were recruited from the First Affiliated Hospital with Nan-jing Medical University.They were randomly assigned into the control group,SMA group and M1 group,with 20 patients in each group.All the groups received medication and conventional rehabilitation.On this basis,SMA group underwent HF-rTMS on the affected side's SMA,while M1 group received HF-rTMS on the affected side's M1 for two weeks.All the groups were measured with motor evoked potentials(MEP),the serial reaction time(RT)task,Fugl-Meyer Assessment-Upper Extremities(FMA-UE)and modified Barthel Index(MBI)before and after intervention.Results The SMA and M1 groups dropped one case respectively.MEP elicitation rate of the affected side's increased in SMA and M1 groups(P<0.05),and it was better than that in the control group(χ2>4.792,P<0.05).The intra-group effects of RTsequential sequence,FMA-UE and MBI scores were significant(|F|>81.546,P<0.05).The inter-group effects of RTrandom sequence,RTsequential sequence,?RT,and MBI scores were significant(F>3.228,P<0.05).The in-teractive effects of RTrandom sequence,RTsequential sequence,?RT,FMA-UE and MBI scores were significant(|F|>3.520,P>0.05).After intervention,RTsequential sequence,?RT,FMA-UE and MBI scores improved(P<0.05).RTrandom sequence was lower in SMA group than in the control group(P<0.017),RTsequential sequence,?RT,FMA-UE and MBI scores im-proved more in SMA and M1 groups than in the control group(P<0.05),but no significant difference was found between the SMA group and the M1 group(P>0.05).Conclusion HF-rTMS applied to the affected SMA or M1 can activate motor sequence learning and promote the recov-ery of upper limb function in stroke patients.

Objective To investigate the effects of high-frequency repetitive transcranial magnetic stimulation(HF-rTMS)applied to the supplementary motor area(SMA)or primary motor cortex(M1)on upper limb function in stroke patients in terms of motor sequence learning.Methods From April,2024 to February,2025,60 inpatients were recruited from the First Affiliated Hospital with Nan-jing Medical University.They were randomly assigned into the control group,SMA group and M1 group,with 20 patients in each group.All the groups received medication and conventional rehabilitation.On this basis,SMA group underwent HF-rTMS on the affected side's SMA,while M1 group received HF-rTMS on the affected side's M1 for two weeks.All the groups were measured with motor evoked potentials(MEP),the serial reaction time(RT)task,Fugl-Meyer Assessment-Upper Extremities(FMA-UE)and modified Barthel Index(MBI)before and after intervention.Results The SMA and M1 groups dropped one case respectively.MEP elicitation rate of the affected side's increased in SMA and M1 groups(P<0.05),and it was better than that in the control group(χ2>4.792,P<0.05).The intra-group effects of RTsequential sequence,FMA-UE and MBI scores were significant(|F|>81.546,P<0.05).The inter-group effects of RTrandom sequence,RTsequential sequence,?RT,and MBI scores were significant(F>3.228,P<0.05).The in-teractive effects of RTrandom sequence,RTsequential sequence,?RT,FMA-UE and MBI scores were significant(|F|>3.520,P>0.05).After intervention,RTsequential sequence,?RT,FMA-UE and MBI scores improved(P<0.05).RTrandom sequence was lower in SMA group than in the control group(P<0.017),RTsequential sequence,?RT,FMA-UE and MBI scores im-proved more in SMA and M1 groups than in the control group(P<0.05),but no significant difference was found between the SMA group and the M1 group(P>0.05).Conclusion HF-rTMS applied to the affected SMA or M1 can activate motor sequence learning and promote the recov-ery of upper limb function in stroke patients.

Objective:To analyze the health system appeal orders from Beijing 12345 citizen service hotline, for references for further promoting the efficient implementation of swift response to publis complaints in Beijing.Methods:12345 citizen service hotline orders received by Beijing health system from 2021 to 2023 were collected. The spatial and temporal distribution of orders and its appeal text were analyzed. Unit root test and cointegration test were used to determine the correlation between the number of effective appeal orders and the number of notifable disease cases in Beijing. Pearson correlation analysis was used to analyze the correlation between the number of effective appeal orders received by tertiary hospitals and their medical service volume.Results:From 2021 to 2023, there were 252.6 thousand valid orders with an increasing trend year by year; There was a time series correlation( P<0.001) between the number of orders and the number of notifable disease cases. There were 231.8 thousand effective appeal orders for tertiary hospitals, which were densely distributed in Xicheng District, and their quantity was positively correlated with the medical service volume of tertiary hospitals( P<0.001). The most common type of work order was medical service management(215.5 thousand items), and the number of orders related to patient experience and performance evaluation of tertiary hospitals had been increasing year by year. Conclusions:The number of work orders in the health system from the 12345 citizen service hotline in Beijing had been increasing year by year, and the number of orders were effected by the volume of public health emergencies and medical services provided by tertiary hospitals; The classification of demands in existing work orders was not detailed enough. It was recommended to strengthen departmental linkage, establish early warning and response mechanisms, formulate refined classification standards for orders, and accurately assess potential demands. Moreover, it was necessary to focus on the patient, move the gate of " Handling Complaints Immediately" forward, truly realize the handling complaints before they are filed and proactive governance, and promote high-quality development of health field.

Objective:To analyze the health system appeal orders from Beijing 12345 citizen service hotline, for references for further promoting the efficient implementation of swift response to publis complaints in Beijing.Methods:12345 citizen service hotline orders received by Beijing health system from 2021 to 2023 were collected. The spatial and temporal distribution of orders and its appeal text were analyzed. Unit root test and cointegration test were used to determine the correlation between the number of effective appeal orders and the number of notifable disease cases in Beijing. Pearson correlation analysis was used to analyze the correlation between the number of effective appeal orders received by tertiary hospitals and their medical service volume.Results:From 2021 to 2023, there were 252.6 thousand valid orders with an increasing trend year by year; There was a time series correlation( P<0.001) between the number of orders and the number of notifable disease cases. There were 231.8 thousand effective appeal orders for tertiary hospitals, which were densely distributed in Xicheng District, and their quantity was positively correlated with the medical service volume of tertiary hospitals( P<0.001). The most common type of work order was medical service management(215.5 thousand items), and the number of orders related to patient experience and performance evaluation of tertiary hospitals had been increasing year by year. Conclusions:The number of work orders in the health system from the 12345 citizen service hotline in Beijing had been increasing year by year, and the number of orders were effected by the volume of public health emergencies and medical services provided by tertiary hospitals; The classification of demands in existing work orders was not detailed enough. It was recommended to strengthen departmental linkage, establish early warning and response mechanisms, formulate refined classification standards for orders, and accurately assess potential demands. Moreover, it was necessary to focus on the patient, move the gate of " Handling Complaints Immediately" forward, truly realize the handling complaints before they are filed and proactive governance, and promote high-quality development of health field.

Objective:To evaluate the value of the crescent sign for predicting the invasiveness of lung adenocarcinoma presenting as pure ground-glass nodule (pGGN).Methods:The clinical, pathological and imaging data of 316 patients (320 pGGNs) confirmed lung adenocarcinoma by surgery and pathology from July 2013 to June 2018 in the First Affiliated Hospital of Wenzhou Medical University were retrospectively analyzed. All pGGNs were divided into preinvasive group (148 pGGNs) and invasive group (172 pGGNs) according to histopathology. Logistic regression analysis was used to determine the risk factors for invasiveness of pGGN, and the ROC curve analysis was performed on each risk factor.Results:Crescent sign was found in 24 cases (16.2%) in the preinvasive group and 49 (28.5%) in the invasive group, and the difference between the two groups was statistically significant (χ2=6.804 ,P=0.009).There were statistically significant differences in patient′s age, lesion size, shape, lobulation sign, and vascular stretch sign between the two groups ( P<0.05). The ROC curve showed that with the lesion size 10.5 mm as the optimal cut off value, the sensitivity for differential diagnosis of preinvasive and invasive lesions was 65.7%, the specificity was 61.5%, and the area under the curve was 0.666. Logistic regression analysis showed that maximum diameter of the lesion ≥10.5 mm, irregular shape, crescent sign and vascular stretch were independent risk factors of invasiveness of pGGN, and the OR value (95%CI) were 3.192 (1.981-5.144), 3.672 (1.545-8.725), 1.972 (1.104-3.521), and 2.026 (1.087-3.777), respectively. A logistic model was established based on the above four independent risk factors, and the area under curve was 0.711 (95%CI 0.655-0.768). Conclusion:Crescent sign can effectively reflect the invasiveness of pGGN. Maximum diameter of the lesion ≥10.5 mm, irregular shape, crescent sign and vascular stretch sign are independent risk factors of invasiveness of pGGN.