1.Application Effect of an Intelligent Medical Record Writing Assistant in Inpatient Medical Record Practice
Xiaoyuan GAO ; Landi SUN ; Xiaolei QIN ; Lei ZUO ; Shihao LIAO ; Qianqian LIU ; Wei ZHAO ; Xiaolin DIAO
Medical Journal of Peking Union Medical College Hospital 2025;17(1):217-222
To investigate the effectiveness of a self-developed intelligent medical record writing assistant in enhancing the efficiency of discharge record writing and improving the quality of discharge records, and to assess physicians' satisfaction with the assistant. This study was conducted as a prospective cluster-randomized controlled trial. From January 25 to June 25, 2024, clinicians in the coronary heartdisease ward of Fuwai Hospital, Chinese Academy of Medical Sciences were selected as the research object. Using the method of cluster-randomized allocation, the four wards were randomly assigned 1∶1, with physicians and their medical records assigned to the corresponding group based on the ward. The experimental group utilized the intelligent medical record writing assistant, with 46 physicians included and 4105 medical records collected. The control group used traditional writing methods, with 41 physicians included and 4680 medical records collected. Primary outcome measures included quantitative analysis of medical record writing efficiency and medical record writing quality. Secondary outcomes assessed physicians' satisfaction with the use of the intelligent medical record writing assistant. The average writing time for discharge records in the experimental group was significantly shorter than that in the control group(5.73 min The intelligent medical record writing assistant can significantly enhance the writing efficiency and optimize medical record quality concurrently, and physicians are highly satisfied with it. This study validates the effectiveness of the new model of intelligent medical record writing applied to clinical practice, and provides a paradigm for the in-depth application and promotion of this model in the future.
2.Study on the Role of Low Expression SLC1A4 in Cisplatin Resistance in Ovarian Cancer
Landi SU ; Jianming PENG ; Yixiao BAO ; Guozheng SUN ; Fanchao ZHOU ; Dingwen XU
Chinese Journal of Modern Applied Pharmacy 2024;41(9):1204-1213
OBJECTIVE
To investigate the role of solute carrier family 1 member 4(SLC1A4) in platinum-based chemotherapy resistance in ovarian cancer.
METHODS
The expression of SLC1A4 in ovarian cancer or platinum-resistant ovarian cancer was analyzed by GEO and TCGA database analysis tools. The expression of SLC1A4 in platinum-treated ovarian cancer cell lines was analyzed by GEO database. The relation of SLC1A4 expression and overall survival(OS) or progression free survival(PFS) in ovarian cancer patients were analyzed by Kaplan Meier-plotter. Correlation between SLC1A4 gene effect and sensitivity to chemotherapeutic agents in ovarian cancer was analyzed through DepMap platform. Low expression of SLC1A4 mediates cisplatin resistance in ovarian cancer cells as verified by flow cytometry and tumor cell clone colony formation assays; prediction of microRNAs(miRNA) targeting SLC1A4 was conducted using TargetScan then validated their correlation in TCGA ovarian cancer samples. Used COREMINE tool to analyze the biological processes of SLC1A4 mediating chemoresistance in ovarian cancer.
RESULTS
SLC1A4 was significantly reduced in ovarian cancer patients and platinum-resistant ovarian cancer(P<0.05) and significantly correlated with OS and PFS in ovarian cancer patients(P<0.05). SLC1A4 expression was increased in ovarian cancer cells with platinum treatment. The genetic effect of SLC1A4 on ovarian cancer was positively correlated with platinum drug sensitivity. Overexpression of SLC1A4 increased cisplatin-induced apoptosis and reduced tumor cell colony formation in ovarian cancer cells. Hsa-let-7c-5p was targeted to SLC1A4 and significantly negatively correlated in samples from drug-resistant ovarian cancer patients.
CONCLUSION
Low expression of SLC1A4 mediates platinum drug resistance in ovarian cancer and is potentially associated with hsa-let-7c-5p regulation.
Result Analysis
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